Search Results - "Griñan, Tania"

Sticholysin II-mediated cytotoxicity involves the activation of regulated intracellular responses that anticipates cell death by Soto, Carmen, Bergado, Gretchen, Blanco, Rancés, Griñán, Tania, Rodríguez, Hermis, Ros, Uris, Pazos, Fabiola, Lanio, María Eliana, Hernández, Ana María, Álvarez, Carlos

“…Sticholysin II (StII) is a pore-forming toxin of biomedical interest that belongs to the actinoporin protein family. Sticholysins are currently under…”
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Anti-NeuGcGM3 reactivity: a possible role of natural antibodies and B-1 cells in tumor immunosurveillance by Rodriguez-Zhurbenko, Nely, Rabade-Chediak, Maura, Martinez, Darel, Griñan, Tania, Hernandez, Ana Maria

“…While not naturally expressed in normal human tissues, N‐glycolylated (NeuGc) gangliosides are overexpressed in several tumors and have immunosuppressive…”
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Characterization of the Antibody Response against NeuGcGM3 Ganglioside Elicited in Non-Small Cell Lung Cancer Patients Immunized with an Anti-Idiotype Antibody by Hernandez, Ana Maria, Toledo, Darien, Martinez, Darel, Grinan, Tania, Brito, Victor, Macias, Amparo, Alfonso, Sailyn, Rondon, Teresa, Suarez, Eduardo, Vazquez, Ana Maria, Perez, Rolando

“…1E10 mAb is an anti-Id murine mAb (Ab2 mAb) specific for an Ab1 mAb that reacts with NeuGc-containing gangliosides, sulfatides, and Ags expressed in some human…”
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Dose-Dependent Induction of an Idiotypic Cascade by Anti-Glycosaminoglycan Monoclonal Antibody in apoE -/- Mice: Association with Atheroprotection by Sarduy, Roger, Brito, Victor, Castillo, Adriana, Soto, Yosdel, Griñán, Tania, Marleau, Sylvie, Vázquez, Ana María

“…Atherosclerosis, the underlying pathology of most cardiovascular diseases, is triggered by the retention of apolipoprotein B (apoB)-containing lipoproteins in…”
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Arresting progressive atherosclerosis by immunization with an anti-glycosaminoglycan monoclonal antibody in apolipoprotein E-deficient mice by Delgado-Roche, Livan, Brito, Víctor, Acosta, Emilio, Pérez, Arlenis, Fernández, Julio R., Hernández-Matos, Yanet, Griñán, Tania, Soto, Yosdel, León, Olga S., Marleau, Sylvie, Vázquez, Ana M.

“…Atherogenesis is associated with the early retention of low-density lipoproteins (LDL) in the arterial intima by interaction with glycosaminoglycan (GAG)-side…”
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Human antibodies reactive to NeuGcGM3 ganglioside have cytotoxic antitumor properties by Rodríguez‐Zhurbenko, Nely, Martínez, Darel, Blanco, Rancés, Rondón, Teresa, Griñán, Tania, Hernández, Ana María

“…N‐glycolylated gangliosides are not naturally expressed in healthy human tissues but are overexpressed in several tumors. We demonstrate the existence of…”
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Anti-NeuGcGM3 antibodies, actively elicited by idiotypic vaccination in nonsmall cell lung cancer patients, induce tumor cell death by an oncosis-like mechanism by Hernández, Ana María, Rodríguez, Nely, González, Jorge E, Reyes, Emma, Rondón, Teresa, Griñán, Tania, Macías, Amparo, Alfonso, Sailyn, Vázquez, Ana María, Pérez, Rolando

“…1E10 is a murine anti-idiotypic mAb specific for an idiotypic mAb that reacts with NeuGc-containing gangliosides, sulfatides, and Ags expressed in some human…”
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Targeting arterial wall sulfated glycosaminoglycans in rabbit atherosclerosis with a mouse/human chimeric antibody by Soto, Yosdel, Mesa, Niurka, Alfonso, Yumisley, Pérez, Arlenis, Batlle, Fernando, Griñán, Tania, Pino, Adonis, Viera, Justo, Frómeta, Milagros, Brito, Victor, Olivera, Armando, Zayas, Francisco, Vázquez, Ana M

“…The progression of atherosclerosis is favored by increasing amounts of chondroitin sulfate proteoglycans in the artery wall. We previously reported the…”
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Antiatherosclerotic Effect of an Antibody That Binds to Extracellular Matrix Glycosaminoglycans by Soto, Yosdel, Acosta, Emilio, Delgado, Livan, Pérez, Arlenis, Falcón, Viviana, Bécquer, María A, Fraga, Ángela, Brito, Víctor, Álvarez, Irene, Griñán, Tania, Fernández-Marrero, Yuniel, López-Requena, Alejandro, Noa, Miriam, Fernández, Eduardo, Vázquez, Ana María

“…OBJECTIVE—Subendothelial retention of proatherogenic lipoproteins by proteoglycans is critical in atherosclerosis. The aim of this study was to characterize…”
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Human antibodies reactive to N eu G c GM 3 ganglioside have cytotoxic antitumor properties by Rodríguez‐Zhurbenko, Nely, Martínez, Darel, Blanco, Rancés, Rondón, Teresa, Griñán, Tania, Hernández, Ana María

“…N ‐ glycolylated gangliosides are not naturally expressed in healthy human tissues but are overexpressed in several tumors. We demonstrate the existence of…”
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Switching on cytotoxicity by a single mutation at the heavy chain variable region of an anti-ganglioside antibody by Fernández-Marrero, Yuniel, Hernández, Tays, Roque-Navarro, Lourdes, Talavera, Ariel, Moreno, Ernesto, Griñán, Tania, Vázquez, Ana María, de Acosta, Cristina Mateo, Pérez, Rolando, López-Requena, Alejandro

“…Gangliosides are sialic acid-containing glycosphingolipids present in the plasma membrane of most mammalian cells. In humans, the expression of the…”
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Dose-dependent Induction of an Idiotypic Cascade by Anti-glycosaminoglycan Monoclonal Antibody in apoE−/− Mice: Association with Atheroprotection by Garcia, Roger Sarduy, Navarro, Victor Brito, Castillo, Adriana, Soto, Yosdel, Griñan, Tania, Marleau, Sylvie, Vázquez, Ana María

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Abstract 466: Therapeutic Immunization with an Antiglycosaminoglycan Antibody Reduces Atherosclerotic Lesion Progression in Apolipoprotein E-Deficient Mice by Sarduy, Roger, Brito, Victor, Soto, Yosdel, Delgado-Roche, Livan, Griñán, Tania, Viera, Justo, González, Jordan, Marleau, Sylvie, Vázquez, Ana M

“…Abstract only Subendothelial retention of apoB-containing lipoproteins by interaction with glycosaminoglycan-side chains of proteoglycans is considered the key…”
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Natural cytotoxic anti-tumor antibodies against NeuGcGM3 in healthy donors (127.4) by Hernandez, Ana, Rodríguez, Nely, Martínez, Darel, Rondón, Teresa, Griñán, Tania

“…N-glycolylated (NeuGc) gangliosides are not naturally expressed in normal human tissues but are overexpressed in several tumors and have immunosuppressive…”
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P3 mAb: An Immunogenic Anti-NeuGcGM3 Antibody with Unusual Immunoregulatory Properties by Martínez, Darel, Rodríguez, Nely, Griñán, Tania, Rondón, Teresa, Vázquez, Ana María, Pérez, Rolando, Hernández, Ana María

“…P3 is a murine IgM mAb that recognize N-glycosylated gangliosides, sulfatides, and antigens expressed in melanoma, breast, and lung human tumors. This antibody…”
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B cells and CD8+ T cells interaction during the establishment of an anti-idiotypic response against the syngeneic monoclonal antibody P3 by Darel Martínez-Bedoya, Ana M Hernández-Vázquez, Teresa Rondón-Corrales, Tania Griñán-Ramirez, Nely Rodríguez-Zhurbenko, Amaury Pupo-Meriño, Lianet Cabrera-López, Judith Raymond-Pous, Ana M Vázquez-Gallo, Rolando Pérez-Rodríguez

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Targeting arterial wall sulfated glycosaminoglycans in rabbit atherosclerosis with a mouse/human chimeric antibody by Soto, Yosdel, Mesa, Niurka, Alfonso, Yumisley, Pérez, Arlenis, Batlle, Fernando, Griñán, Tania, Pino, Adonis, Viera, Justo, Frómeta, Milagros, Brito, Victor, Olivera, Armando, Zayas, Francisco, Vázquez, Ana M

“…The progression of atherosclerosis is favored by increasing amounts of chondroitin sulfate proteoglycans in the artery wall. We previously reported the…”
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