Search Results - "Greytak, Sarah"

A review of preanalytical factors affecting molecular, protein, and morphological analysis of formalin-fixed, paraffin-embedded (FFPE) tissue: how well do you know your FFPE specimen? by Bass, B Paige, Engel, Kelly B, Greytak, Sarah R, Moore, Helen M

“…Formalin fixation and paraffin embedding is a timeless, cost-efficient, and widely adopted method of preserving human tissue biospecimens that has resulted in…”
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Harmonizing Cell-Free DNA Collection and Processing Practices through Evidence-Based Guidance by Greytak, Sarah R, Engel, Kelly B, Parpart-Li, Sonya, Murtaza, Muhammed, Bronkhorst, Abel J, Pertile, Mark D, Moore, Helen M

“…Circulating cell-free DNA (cfDNA) is rapidly transitioning from discovery research to an important tool in clinical decision making. However, the lack of…”
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Understanding preanalytical variables and their effects on clinical biomarkers of oncology and immunotherapy by Agrawal, Lokesh, Engel, Kelly B., Greytak, Sarah R., Moore, Helen M.

“…Identifying a suitable course of immunotherapy treatment for a given patient as well as monitoring treatment response is heavily reliant on biomarkers detected…”
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Accuracy of Molecular Data Generated with FFPE Biospecimens: Lessons from the Literature by Greytak, Sarah R, Engel, Kelly B, Bass, B Paige, Moore, Helen M

“…Formalin-fixed and paraffin-embedded (FFPE) tissue biospecimens are a valuable resource for molecular cancer research. Although much can be gained from their…”
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Deleterious effects of formalin-fixation and delays to fixation on RNA and miRNA-Seq profiles by Jones, Wendell, Greytak, Sarah, Odeh, Hana, Guan, Ping, Powers, Jason, Bavarva, Jasmin, Moore, Helen M.

“…The National Cancer Institute conducted the Biospecimen Pre-analytical Variables (BPV) study to determine the effects of formalin fixation and delay to…”
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Notable Histologic Findings in a "Normal" Cohort: The National Institutes of Health Genotype-Tissue Expression (GTEx) Project by Branton, Philip A, Sobin, Leslie, Barcus, Mary, Engel, Kelly B, Greytak, Sarah R, Guan, Ping, Vaught, Jim, Moore, Helen M

“…The National Institutes of Health (NIH) Genotype-Tissue Expression (GTEx) project was designed to evaluate how genetic variation and epigenetic effects…”
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Evidence-based procedures to improve the reliability of circulating miRNA biomarker assays by Greytak, Sarah R, Engel, Kelly B, Hoon, Dave S B, Elias, Kevin M, Lockwood, Christina M, Guan, Ping, Moore, Helen M

“…Circulating cell-free microRNAs (cfmiRNA) are an emerging class of biomarkers that have shown great promise in the clinical diagnosis, treatment, and…”
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Histologic and Quality Assessment of Genotype-Tissue Expression (GTEx) Research Samples: A Large Postmortem Tissue Collection by Sobin, Leslie, Barcus, Mary, Branton, Philip A, Engel, Kelly B, Keen, Judy, Tabor, David, Ardlie, Kristin G, Greytak, Sarah R, Roche, Nancy, Luke, Brian, Vaught, Jim, Guan, Ping, Moore, Helen M

“…The National Institutes of Health Genotype-Tissue Expression (GTEx) project was developed to elucidate how genetic variation influences gene expression in…”
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Formalin Fixation, Delay to Fixation, and Time in Fixative Adversely Impact Copy Number Variation Analysis by aCGH by Li, James, Greytak, Sarah R, Guan, Ping, Engel, Kelly B, Goerlitz, David S, Islam, Md, Varghese, Rency S, Moore, Helen M, Ressom, Habtom W

“…Although molecular profiling of DNA isolated from formalin-fixed, paraffin-embedded (FFPE) tumor specimens has become more common in recent years, it remains…”
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Maximizing the Utility of Archival Formalin-Fixed Paraffin-Embedded Blocks for Nucleic Acid Analysis by Greytak, Sarah R, Engel, Kelly B, Moore, Helen M

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Cloning of three estrogen receptors (ER) from killifish ( Fundulus heteroclitus ): Differences in populations from polluted and reference environments by Greytak, Sarah R, Callard, Gloria V

“…Abstract Epidemiological, wildlife, and laboratory studies support the hypothesis that chemicals released into the environment through anthropogenic activities…”
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Estrogen responses in killifish ( Fundulus heteroclitus) from polluted and unpolluted environments are site- and gene-specific by Greytak, Sarah R., Tarrant, Ann M., Nacci, Diane, Hahn, Mark E., Callard, Gloria V.

“…Epidemiological, ecological, and laboratory-based studies support the hypothesis that endocrine disrupting chemicals (EDCs) in the environment are responsible…”
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Formin Homology 2 Domain Containing 3 Variants Associated With Hypertrophic Cardiomyopathy by Wooten, Eric C, Hebl, Virginia B, Wolf, Matthew J, Greytak, Sarah R, Orr, Nicole M, Draper, Isabelle, Calvino, Jenna E, Kapur, Navin K, Maron, Martin S, Kullo, Iftikhar J, Ommen, Steve R, Bos, J Martijn, Ackerman, Michael J, Huggins, Gordon S

“…BACKGROUND—Incomplete penetrance and variable expression of hypertrophic cardiomyopathy (HCM) is well appreciated. Common genetic polymorphisms variants that…”
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National Cancer Institute Biospecimen Evidence-Based Practices: Harmonizing Procedures for Nucleic Acid Extraction from Formalin-Fixed, Paraffin-Embedded Tissue by Greytak, Sarah R, Engel, Kelly B, Zmuda, Erik, Casas-Silva, Esmeralda, Guan, Ping, Hoadley, Katherine A, Mungall, Andrew J, Wheeler, David A, Doddapaneni, Harsha V, Moore, Helen M

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The Biospecimen Preanalytical Variables Program: A Multiassay Comparison of Effects of Delay to Fixation and Fixation Duration on Nucleic Acid Quality by Carithers, Latarsha J, Agarwal, Rachana, Guan, Ping, Odeh, Hana, Sachs, Michael C, Engel, Kelly B, Greytak, Sarah R, Barcus, Mary, Soria, Conrado, Lih, Chih-Jian Jason, Williams, P Mickey, Branton, Philip A, Sobin, Leslie, Fombonne, Benjamin, Bocklage, Therese, Andry, Chris, Duffy, Elizabeth R, Sica, Gabriel, Dhir, Rajiv, Jewell, Scott, Roche, Nancy, Moore, Helen M

“…Despite widespread use of formalin-fixed, paraffin-embedded (FFPE) tissue in clinical and research settings, potential effects of variable tissue processing…”
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Isolation and characterization of two cytochrome P450 aromatase forms in killifish ( Fundulus heteroclitus): Differential expression in fish from polluted and unpolluted environments by Greytak, Sarah R., Champlin, Denise, Callard, Gloria V.

“…Populations of killifish ( Fundulus heteroclitus) persist in many different highly polluted environment indicative of adaptation or tolerance. In this study,…”
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Increased FOG-2 in Failing Myocardium Disrupts Thyroid Hormone–Dependent SERCA2 Gene Transcription by Rouf, Rosanne, Greytak, Sarah, Wooten, Eric C, Wu, Jing, Boltax, Jay, Picard, Michael, Svensson, Eric C, Dillmann, Wolfgang H, Patten, Richard D, Huggins, Gordon S

“…Reduced expression of sarcoplasmic reticulum calcium ATPase (SERCA)2 and other genes in the adult cardiac gene program has raised consideration of an impaired…”
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Abstract 5264: The National Cancer Institute's biospecimen research database: A community resource for improving specimen quality by Engel, Kelly B., Greytak, Sarah R., Guan, Ping, Moore, Helen

“…Tissue and blood biospecimens used in cancer research are collected, processed and stored using standard operating procedures (SOPs) that can vary tremendously…”
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Abstract 4763: NCI's Expert-Vetted Biospecimen Evidence-Based Practices (BEBP): A resource for harmonization of biospecimen collection procedures by Casas-Silva, Esmeralda, Campbell, Lori D., Engel, Kelly, Greytak, Sarah, Guan, Ping, Moore, Helen

“…High quality human biospecimens are essential to clinical diagnosis and treatment and serve as a vital foundation for medical research. Substantial variation…”
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Deletion of GSK-3β in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation by Kerkela, Risto, Kockeritz, Lisa, MacAulay, Katrina, Zhou, Jibin, Doble, Bradley W, Beahm, Cara, Greytak, Sarah, Woulfe, Kathleen, Trivedi, Chinmay M, Woodgett, James R, Epstein, Jonathan A, Force, Thomas, Huggins, Gordon S

“…Based on extensive preclinical data, glycogen synthase kinase-3 (GSK-3) has been proposed to be a viable drug target for a wide variety of disease states,…”
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