Search Results - "Grewal, Shiv I S"

RNA Elimination Machinery Targeting Meiotic mRNAs Promotes Facultative Heterochromatin Formation by Zofall, Martin, Yamanaka, Soichiro, Reyes-Turcu, Francisca E., Zhang, Ke, Rubin, Chanan, Grewal, Shiv I. S.

“…Facultative heterochromatin that changes during cellular differentiation coordinates regulated gene expression, but its assembly is poorly understood. Here, we…”
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Cell cycle control of centromeric repeat transcription and heterochromatin assembly by Grewal, Shiv I. S, Chen, Ee Sin, Zhang, Ke, Nicolas, Estelle, Cam, Hugh P, Zofall, Martin

“…Heterochromatin in eukaryotic genomes regulates diverse chromosomal processes including transcriptional silencing. However, in Schizosaccharomyces pombe RNA…”
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Transcription and RNA interference in the formation of heterochromatin by Grewal, Shiv I. S, Elgin, Sarah C. R

“…Transcription in heterochromatin seems to be an oxymoron--surely the 'silenced' form of chromatin should not be transcribed. But there have been frequent…”
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Heterochromatin revisited by Grewal, Shiv I. S, Jia, Songtao

“…The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and the subsequent recruitment of chromodomain proteins such as…”
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Heterochromatin and Epigenetic Control of Gene Expression by Shiv I. S. Grewal, Moazed, Danesh

“…Eukaryotic DNA is organized into structurally distinct domains that regulate gene expression and chromosome behavior. Epigenetically heritable domains of…”
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Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy by Folco, H. Diego, Chalamcharla, Venkata R., Sugiyama, Tomoyasu, Thillainadesan, Gobi, Zofall, Martin, Balachandran, Vanivilasini, Dhakshnamoorthy, Jothy, Mizuguchi, Takeshi, Grewal, Shiv I. S.

“…Uniparental disomy in fission yeast is triggered by aberrant expression of gametogenic genes in vegetative cells, and is associated with the activation of…”
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RNAi-Mediated Targeting of Heterochromatin by the RITS Complex by Verdel, André, Jia, Songtao, Gerber, Scott, Sugiyama, Tomoyasu, Gygi, Steven, Shiv I. S. Grewal, Moazed, Danesh

“…RNA interference (RNAi) is a widespread silencing mechanism that acts at both the posttranscriptional and transcriptional levels. Here, we describe the…”
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RNAi triggered by specialized machinery silences developmental genes and retrotransposons by Yamanaka, Soichiro, Mehta, Sameet, Reyes-Turcu, Francisca E., Zhuang, Fanglei, Fuchs, Ryan T., Rong, Yikang, Robb, Gregory B., Grewal, Shiv I. S.

“…In the fission yeast Schizosaccharomyces pombe RNA interference (RNAi) machinery promotes heterochromatin assembly and silencing of centromeric repeats; here…”
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Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing by Chalamcharla, Venkata R., Folco, H. Diego, Dhakshnamoorthy, Jothy, Grewal, Shiv I. S.

“…Cotranscriptional RNA processing and surveillance factors mediate heterochromatin formation in diverse eukaryotes. In fission yeast, RNAi machinery and RNA…”
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Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi by Volpe, Thomas A., Kidner, Catherine, Hall, Ira M., Teng, Grace, Shiv I. S. Grewal, Martienssen, Robert A.

“…Eukaryotic heterochromatin is characterized by a high density of repeats and transposons, as well as by modified histones, and influences both gene expression…”
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RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins by Jia, S, Noma, K, Grewal, S.I.S

“…At the silent mating-type interval of fission yeast, the RNA interference (RNAi) machinery cooperates with cenH, a DNA element homologous to centromeric…”
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RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing by Grewal, Shiv I S, Noma, Ken-ichi, Sugiyama, Tomoyasu, Cam, Hugh, Verdel, Andre, Zofall, Martin, Jia, Songtao, Moazed, Danesh

“…RNA interference is a conserved mechanism by which double-stranded RNA is processed into short interfering RNAs (siRNAs) that can trigger both…”
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Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast by Watanabe, Yoshinori, Nonaka, Nobuhiro, Kitajima, Tomoya, Yokobayashi, Shihori, Xiao, Guoping, Yamamoto, Masayuki, Grewal, Shiv I. S

“…Fission yeast centromeres, like those of higher eukaryotes, are composed of repeated DNA structures and associated heterochromatin protein complexes, that have…”
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Host genome surveillance for retrotransposons by transposon-derived proteins by Grewal, Shiv I. S, Cam, Hugh P, Noma, Ken-ichi, Ebina, Hirotaka, Levin, Henry L

“…Transposable elements and their remnants constitute a substantial fraction of eukaryotic genomes. Host genomes have evolved defence mechanisms, including…”
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Establishment and Maintenance of a Heterochromatin Domain by Hall, Ira M., Shankaranarayana, Gurumurthy D., Noma, Ken-ichi, Ayoub, Nabieh, Cohen, Amikam, Shiv I. S. Grewal

“…The higher-order assembly of chromatin imposes structural organization on the genetic information of eukaryotes and is thought to be largely determined by…”
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Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries by Noma, Ken-ichi, Allis, C. David, Shiv I. S. Grewal

“…Eukaryotic genomes are organized into discrete structural and functional chromatin domains. Here, we show that distinct site-specific histone H3 methylation…”
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Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs by Zofall, Martin, Fischer, Tamás, Zhang, Ke, Zhou, Ming, Cui, Bowen, Veenstra, Timothy D., Grewal, Shiv I. S.

“…Antisense RNAs suppressed by histone H2A.Z Unregulated transcription of antisense RNAs is potentially deleterious to a cell because sense–antisense pairing…”
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Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly by Nakayama, Jun-ichi, Rice, Judd C., Strahl, Brian D., Allis, C. David, Shiv I. S. Grewal

“…The assembly of higher order chromatin structures has been linked to the covalent modifications of histone tails. We provide in vivo evidence that lysine 9 of…”
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Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast by Fischer, Tamás, Cui, Bowen, Dhakshnamoorthy, Jothy, Zhou, Ming, Rubin, Chanan, Zofall, Martin, Veenstra, Timothy D, Grewal, Shiv I.S

“…Conserved chromosomal HP1 proteins capable of binding to histone H3 methylated at lysine 9 are believed to provide a dynamic platform for the recruitment…”
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Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin by Grewal, Shiv I. S, Jia, Songtao, Kobayashi, Ryuji

“…In eukaryotes, heterochromatin mediates diverse processes including gene silencing and regulation of long-range chromatin interactions. The formation of…”
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