Search Results - "Grewal, Shiv I"

Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe by Mizuguchi, Takeshi, Fudenberg, Geoffrey, Mehta, Sameet, Belton, Jon-Matthew, Taneja, Nitika, Folco, Hernan Diego, FitzGerald, Peter, Dekker, Job, Mirny, Leonid, Barrowman, Jemima, Grewal, Shiv I. S.

“…Genome-wide chromatin conformation capture (Hi-C) is used to investigate three-dimensional genome organization in Schizosaccharomyces pombe ; small domains of…”
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Heterochromatin revisited by Grewal, Shiv I. S, Jia, Songtao

“…The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and the subsequent recruitment of chromodomain proteins such as…”
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Histone deacetylation primes self-propagation of heterochromatin domains to promote epigenetic inheritance by Zofall, Martin, Sandhu, Rima, Holla, Sahana, Wheeler, David, Grewal, Shiv I. S.

“…Heterochromatin assembly, involving histone H3 lysine-9 methylation (H3K9me), is nucleated at specific genomic sites but can self-propagate across extended…”
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RNA Elimination Machinery Targeting Meiotic mRNAs Promotes Facultative Heterochromatin Formation by Zofall, Martin, Yamanaka, Soichiro, Reyes-Turcu, Francisca E., Zhang, Ke, Rubin, Chanan, Grewal, Shiv I. S.

“…Facultative heterochromatin that changes during cellular differentiation coordinates regulated gene expression, but its assembly is poorly understood. Here, we…”
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Cell cycle control of centromeric repeat transcription and heterochromatin assembly by Grewal, Shiv I. S, Chen, Ee Sin, Zhang, Ke, Nicolas, Estelle, Cam, Hugh P, Zofall, Martin

“…Heterochromatin in eukaryotic genomes regulates diverse chromosomal processes including transcriptional silencing. However, in Schizosaccharomyces pombe RNA…”
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Transcription and RNA interference in the formation of heterochromatin by Grewal, Shiv I. S, Elgin, Sarah C. R

“…Transcription in heterochromatin seems to be an oxymoron--surely the 'silenced' form of chromatin should not be transcribed. But there have been frequent…”
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The cysteine-rich domain in CENP-A chaperone Scm3HJURP ensures centromere targeting and kinetochore integrity by Folco, H Diego, Xiao, Hua, Wheeler, David, Feng, Hanqiao, Bai, Yawen, Grewal, Shiv I S

“…Abstract Centromeric chromatin plays a crucial role in kinetochore assembly and chromosome segregation. Centromeres are specified through the loading of the…”
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TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation by Wei, Yi, Lee, Nathan N., Pan, Lixia, Dhakshnamoorthy, Jothy, Sun, Ling-Ling, Zofall, Martin, Wheeler, David, Grewal, Shiv I. S.

“…Cell proliferation and differentiation require signalling pathways that enforce appropriate and timely gene expression. We find that Tor2, the catalytic…”
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Heterochromatin and Epigenetic Control of Gene Expression by Shiv I. S. Grewal, Moazed, Danesh

“…Eukaryotic DNA is organized into structurally distinct domains that regulate gene expression and chromosome behavior. Epigenetically heritable domains of…”
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RNAi triggered by specialized machinery silences developmental genes and retrotransposons by Yamanaka, Soichiro, Mehta, Sameet, Reyes-Turcu, Francisca E., Zhuang, Fanglei, Fuchs, Ryan T., Rong, Yikang, Robb, Gregory B., Grewal, Shiv I. S.

“…In the fission yeast Schizosaccharomyces pombe RNA interference (RNAi) machinery promotes heterochromatin assembly and silencing of centromeric repeats; here…”
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Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing by Chalamcharla, Venkata R., Folco, H. Diego, Dhakshnamoorthy, Jothy, Grewal, Shiv I. S.

“…Cotranscriptional RNA processing and surveillance factors mediate heterochromatin formation in diverse eukaryotes. In fission yeast, RNAi machinery and RNA…”
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A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing by Xie, Guodong, Vo, Tommy V., Thillainadesan, Gobi, Holla, Sahana, Zhang, Beibei, Jiang, Yiyang, Lv, Mengqi, Xu, Zheng, Wang, Chongyuan, Balachandran, Vanivilasini, Shi, Yunyu, Li, Fudong, Grewal, Shiv I. S.

“…Gene regulatory mechanisms rely on a complex network of RNA processing factors to prevent untimely gene expression. In fission yeast, the highly conserved…”
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Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy by Folco, H. Diego, Chalamcharla, Venkata R., Sugiyama, Tomoyasu, Thillainadesan, Gobi, Zofall, Martin, Balachandran, Vanivilasini, Dhakshnamoorthy, Jothy, Mizuguchi, Takeshi, Grewal, Shiv I. S.

“…Uniparental disomy in fission yeast is triggered by aberrant expression of gametogenic genes in vegetative cells, and is associated with the activation of…”
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RNAi-Mediated Targeting of Heterochromatin by the RITS Complex by Verdel, André, Jia, Songtao, Gerber, Scott, Sugiyama, Tomoyasu, Gygi, Steven, Shiv I. S. Grewal, Moazed, Danesh

“…RNA interference (RNAi) is a widespread silencing mechanism that acts at both the posttranscriptional and transcriptional levels. Here, we describe the…”
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Host genome surveillance for retrotransposons by transposon-derived proteins by Grewal, Shiv I. S, Cam, Hugh P, Noma, Ken-ichi, Ebina, Hirotaka, Levin, Henry L

“…Transposable elements and their remnants constitute a substantial fraction of eukaryotic genomes. Host genomes have evolved defence mechanisms, including…”
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Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs by Zofall, Martin, Fischer, Tamás, Zhang, Ke, Zhou, Ming, Cui, Bowen, Veenstra, Timothy D., Grewal, Shiv I. S.

“…Antisense RNAs suppressed by histone H2A.Z Unregulated transcription of antisense RNAs is potentially deleterious to a cell because sense–antisense pairing…”
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Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly by Sugiyama, Tomoyasu, Thillainadesan, Gobi, Chalamcharla, Venkata R., Meng, Zhaojing, Balachandran, Vanivilasini, Dhakshnamoorthy, Jothy, Zhou, Ming, Grewal, Shiv I.S.

“…Erh1, the fission yeast homolog of Enhancer of rudimentary, is implicated in meiotic mRNA elimination during vegetative growth, but its function is poorly…”
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RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins by Jia, S, Noma, K, Grewal, S.I.S

“…At the silent mating-type interval of fission yeast, the RNA interference (RNAi) machinery cooperates with cenH, a DNA element homologous to centromeric…”
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Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi by Volpe, Thomas A., Kidner, Catherine, Hall, Ira M., Teng, Grace, Shiv I. S. Grewal, Martienssen, Robert A.

“…Eukaryotic heterochromatin is characterized by a high density of repeats and transposons, as well as by modified histones, and influences both gene expression…”
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Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast by Roguev, Assen, Bandyopadhyay, Sourav, Zofall, Martin, Zhang, Ke, Fischer, Tamas, Collins, Sean R, Qu, Hongjing, Shales, Michael, Park, Han-Oh, Hayles, Jacqueline, Hoe, Kwang-Lae, Kim, Dong-Uk, Ideker, Trey, Grewal, Shiv I, Weissman, Jonathan S, Krogan, Nevan J

“…An epistasis map (E-MAP) was constructed in the fission yeast, Schizosaccharomyces pombe, by systematically measuring the phenotypes associated with pairs of…”
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