Search Results - "Grevelding, Christoph G"

The anticancer drug imatinib induces autophagy in Schistosoma mansoni by Mughal, Mudassar N., Grevelding, Christoph G., Haeberlein, Simone

“…[Display omitted] •Imatinib induces expression of the autophagy marker LC3B in Schistosoma mansoni.•This is blocked by co-treatment of worms with the autophagy…”
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Defining an optimal control for RNAi experiments with adult Schistosoma mansoni by Moescheid, Max F., Puckelwaldt, Oliver, Beutler, Mandy, Haeberlein, Simone, Grevelding, Christoph G.

“…In parasites such as Schistosoma mansoni , gene knockdown by RNA interference (RNAi) has become an indispensable tool for functional gene characterization. To…”
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Proteomic and deep sequencing analysis of extracellular vesicles isolated from adult male and female Schistosoma japonicum by Du, Pengfei, Giri, Bikash R, Liu, Juntao, Xia, Tianqi, Grevelding, Christoph G, Cheng, Guofeng

“…Schistosomes are the causative agent of schistosomiasis, which affects more than 200 million people worldwide. Unlike other trematode parasites, schistosomes…”
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Tissue- and sex-specific lipidomic analysis of Schistosoma mansoni using high-resolution atmospheric pressure scanning microprobe matrix-assisted laser desorption/ionization mass spectrometry imaging by Kadesch, Patrik, Quack, Thomas, Gerbig, Stefanie, Grevelding, Christoph G, Spengler, Bernhard

“…Schistosomes are human pathogens causing the neglected tropical disease schistosomiasis, which occurs worldwide in (sub-)tropical regions. This infectious…”
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Intra-specific variations in Schistosoma mansoni and their possible contribution to inconsistent virulence and diverse clinical outcomes by Dannenhaus, Tim A, Winkelmann, Franziska, Reinholdt, Cindy, Bischofsberger, Miriam, Dvořák, Jan, Grevelding, Christoph G, Löbermann, Micha, Reisinger, Emil C, Sombetzki, Martina

“…Schistosoma mansoni was introduced from Africa to the Americas during the transatlantic slave trade and remains a major public health problem in parts of South…”
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Drug Repurposing and De Novo Drug Discovery of Protein Kinase Inhibitors as New Drugs against Schistosomiasis by Pereira Moreira, Bernardo, Weber, Michael H W, Haeberlein, Simone, Mokosch, Annika S, Spengler, Bernhard, Grevelding, Christoph G, Falcone, Franco H

“…Schistosomiasis is a neglected tropical disease affecting more than 200 million people worldwide. Chemotherapy relies on one single drug, praziquantel, which…”
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Molecular characterization of Smtdc-1 and Smddc-1 discloses roles as male-competence factors for the sexual maturation of Schistosoma mansoni females by Li, Xuesong, Weth, Oliver, Haeberlein, Simone, Grevelding, Christoph G.

“…Introduction Schistosomes are the only mammalian flatworms that have evolved separate sexes. A key question of schistosome research is the male-dependent…”
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Hepatocyte integrity depends on c-Jun-controlled proliferation in Schistosoma mansoni infected mice by Härle, Lukas, von Bülow, Verena, Knedla, Lukas, Stettler, Frederik, Müller, Heike, Zahner, Daniel, Haeberlein, Simone, Windhorst, Anita, Tschuschner, Annette, Burg-Roderfeld, Monika, Köhler, Kernt, Grevelding, Christoph G., Roeb, Elke, Roderfeld, Martin

“…Schistosomiasis is a parasitic disease affecting more than 250 million people worldwide . The transcription factor c-Jun, which is induced in S.   mansoni…”
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Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation by Peine, Michael, Rausch, Sebastian, Helmstetter, Caroline, Fröhlich, Anja, Hegazy, Ahmed N, Kühl, Anja A, Grevelding, Christoph G, Höfer, Thomas, Hartmann, Susanne, Löhning, Max

“…Differentiated T helper (Th) cell lineages are thought to emerge from alternative cell fate decisions. However, recent studies indicated that differentiated Th…”
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Tissue-specific transcriptome analyses provide new insights into GPCR signalling in adult Schistosoma mansoni by Hahnel, Steffen, Wheeler, Nic, Lu, Zhigang, Wangwiwatsin, Arporn, McVeigh, Paul, Maule, Aaron, Berriman, Matthew, Day, Timothy, Ribeiro, Paula, Grevelding, Christoph G

“…Schistosomes are blood-dwelling trematodes with global impact on human and animal health. Because medical treatment is currently based on a single drug,…”
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Males, the Wrongly Neglected Partners of the Biologically Unprecedented Male-Female Interaction of Schistosomes by Lu, Zhigang, Spänig, Sebastian, Weth, Oliver, Grevelding, Christoph G

“…Schistosomes are the only platyhelminths that have evolved separate sexes, and they exhibit a unique reproductive biology because the female's sexual…”
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Arylmethylamino steroids as antiparasitic agents by Krieg, Reimar, Jortzik, Esther, Goetz, Alice-Anne, Blandin, Stéphanie, Wittlin, Sergio, Elhabiri, Mourad, Rahbari, Mahsa, Nuryyeva, Selbi, Voigt, Kerstin, Dahse, Hans-Martin, Brakhage, Axel, Beckmann, Svenja, Quack, Thomas, Grevelding, Christoph G., Pinkerton, Anthony B., Schönecker, Bruno, Burrows, Jeremy, Davioud-Charvet, Elisabeth, Rahlfs, Stefan, Becker, Katja

“…In search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound…”
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Insects in anthelminthics research: Lady beetle-derived harmonine affects survival, reproduction and stem cell proliferation of Schistosoma mansoni by Kellershohn, Josina, Thomas, Laura, Hahnel, Steffen R, Grünweller, Arnold, Hartmann, Roland K, Hardt, Martin, Vilcinskas, Andreas, Grevelding, Christoph G, Haeberlein, Simone

“…Natural products have moved into the spotlight as possible sources for new drugs in the treatment of helminth infections including schistosomiasis…”
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Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates by Obermann, Wiebke, Azri, Mohammad Farhan Darin, Konopka, Leonie, Schmidt, Nina, Magari, Francesca, Sherman, Julian, Silva, Liliana M. R., Hermosilla, Carlos, Ludewig, Andreas H., Houhou, Hicham, Haeberlein, Simone, Luo, Mona Yiting, Häcker, Irina, Schetelig, Marc F., Grevelding, Christoph G., Schroeder, Frank C., Lau, Gilbert Sei Kung, Taubert, Anja, Rodriguez, Ana, Heine, Andreas, Yeo, Tiong Chia, Grünweller, Arnold, Taroncher-Oldenburg, Gaspar

“…Inhibition of eukaryotic initiation factor 4A has been proposed as a strategy to fight pathogens. Rocaglates exhibit the highest specificities among eIF4A…”
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Protein kinases as potential targets for novel anti-schistosomal strategies by Beckmann, Svenja, Leutner, Silke, Gouignard, Nadège, Dissous, Colette, Grevelding, Christoph G

“…Schistosome parasites are the causative pathogens of schistosomiasis (bilharzia), a disease of worldwide significance. In terms of patient numbers,…”
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The Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesis by Beckmann, Svenja, Buro, Christin, Dissous, Colette, Hirzmann, Jörg, Grevelding, Christoph G

“…The signal transduction protein SmTK4 from Schistosoma mansoni belongs to the family of Syk kinases. In vertebrates, Syk kinases are known to play specialized…”
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Evolution of gene dosage on the Z-chromosome of schistosome parasites by Picard, Marion A L, Cosseau, Celine, Ferré, Sabrina, Quack, Thomas, Grevelding, Christoph G, Couté, Yohann, Vicoso, Beatriz

“…XY systems usually show chromosome-wide compensation of X-linked genes, while in many ZW systems, compensation is restricted to a minority of dosage-sensitive…”
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Does Schistosoma Mansoni Facilitate Carcinogenesis? by von Bülow, Verena, Lichtenberger, Jakob, Grevelding, Christoph G., Falcone, Franco H., Roeb, Elke, Roderfeld, Martin

“…Schistosomiasis is one of the most prominent parasite-induced infectious diseases, causing tremendous medical and socioeconomic problems. Current studies have…”
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Venus kinase receptors control reproduction in the platyhelminth parasite Schistosoma mansoni by Vanderstraete, Mathieu, Gouignard, Nadège, Cailliau, Katia, Morel, Marion, Hahnel, Steffen, Leutner, Silke, Beckmann, Svenja, Grevelding, Christoph G, Dissous, Colette

“…The Venus kinase receptor (VKR) is a single transmembrane molecule composed of an intracellular tyrosine kinase domain close to that of insulin receptor and an…”
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Evidence for Integrin - Venus Kinase Receptor 1 Alliance in the Ovary of Schistosoma mansoni Females Controlling Cell Survival by Gelmedin, Verena, Morel, Marion, Hahnel, Steffen, Cailliau, Katia, Dissous, Colette, Grevelding, Christoph G

“…In metazoan integrin signaling is an important process of mediating extracellular and intracellular communication processes. This can be achieved by…”
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