Search Results - "Greupink, R"

Placental transfer and vascular effects of pharmaceutical drugs in the human placenta ex vivo: A review by van Hove, H., Mathiesen, L., Freriksen, J.J.M., Vähäkangas, K., Colbers, A., Brownbill, P., Greupink, R.

“…At least 80% of pregnant woman in Europe use at least one medication during their pregnancy. The majority of these drugs are prescribed off-label. A better…”
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Prediction of Maternal and Fetal Doravirine Exposure by Integrating Physiologically Based Pharmacokinetic Modeling and Human Placenta Perfusion Experiments by Bukkems, V. E., van Hove, H., Roelofsen, D., Freriksen, J. J. M., van Ewijk-Beneken Kolmer, E. W. J., Burger, D. M., van Drongelen, J., Svensson, E. M., Greupink, R., Colbers, A.

“…Background and Objective Doravirine is currently not recommended for pregnant women living with human immunodeficiency virus because efficacy and safety data…”
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Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of OATP1B1 by van de Steeg, E, Greupink, R, Schreurs, M, Nooijen, I H G, Verhoeckx, K C M, Hanemaaijer, R, Ripken, D, Monshouwer, M, Vlaming, M L H, DeGroot, J, Verwei, M, Russel, F G M, Huisman, M T, Wortelboer, H M

“…Organic anion-transporting polypeptide 1B1 (OATP1B1) is an important hepatic uptake transporter, of which the polymorphic variant OATP1B1*15 (Asn130Asp and…”
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Transfer of uremic solutes across the human term placenta: An ex vivo study in the dual-side perfused cotyledon by Schakenraad, L., Van Es, M.J., Meerman, J.J., Van den Broek, P.H.H., Van Hove, H., Van Drongelen, J., Eliesen, G.A.M., Russel, F.G.M., Greupink, R.

“…An increasing number of women becomes pregnant while suffering from chronic kidney disease (CKD). As a result of decreased renal function, uremic solutes…”
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Placental disposition of the immunosuppressive drug tacrolimus in renal transplant recipients and in ex vivo perfused placental tissue by Freriksen, J.J.M., Feyaerts, D., van den Broek, P.H.H., van der Heijden, O.W.H., van Drongelen, J., van Hamersvelt, H.W., Russel, F.G.M., van der Molen, R.G., Greupink, R.

“…Currently, tacrolimus is the most potent immunosuppressive agent for renal transplant recipients and is commonly prescribed during pregnancy. As data on…”
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Experimental study of diclofenac and its biliary metabolites on anastomotic healing by Yauw, S T K, Lomme, R M L M, van den Broek, P, Greupink, R, Russel, F G M, van Goor, H

“…Diclofenac increases the risk of anastomotic leakage, but the underlying mechanism is unknown. As diclofenac is excreted largely as biliary metabolites, the…”
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P05-02 Optimization of the betamethasone and dexamethasone dosing regimen during pregnancy: a combined placenta perfusion and pregnancy physiologically-based pharmacokinetic modeling approach by van der Heijden, J., van Hove, H., van Elst, N., van den Broek, P., van Drongelen, J., Scheepers, H., de Wildt, S., Greupink, R.

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P12-59 Assessing the placental transfer of dexamethasone via ex vivo human placenta perfusions: a step-up towards model informeddrug dosing in pregnancy by van Hove, H., van der Heijden, J.E.M., van den Broek, P., van Elst, N., van Drongelen, J., Colbers, A., de Wildt, S.N., Greupink, R.

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OP08_6. Novel therapeutic strategy in pregnancy: prevention of transplacental passage by lipid nanoparticles by van Kammen, C., Terstappen, F., Strijkers, G., Greupink, R., Schiffelers, R., Lely, T.

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Microbial Glucuronidase Inhibition Reduces Severity of Diclofenac-Induced Anastomotic Leak in Rats by Yauw, Simon T K, Arron, Melissa, Lomme, Roger M L M, van den Broek, Petra, Greupink, Rick, Bhatt, Aadra P, Redinbo, Matthew R, van Goor, Harry

“…The non-steroidal anti-inflammatory drug diclofenac has been associated with intestinal anastomotic leakage, although the underlying pathophysiology is…”
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The antiproliferative drug doxorubicin inhibits liver fibrosis in bile duct-ligated rats and can be selectively delivered to hepatic stellate cells in vivo by Greupink, Rick, Bakker, Hester I, Bouma, Wilma, Reker-Smit, Catharina, Meijer, Dirk K F, Beljaars, Leonie, Poelstra, Klaas

“…Hepatic stellate cell (HSC) proliferation is a key event in liver fibrosis; therefore, pharmacological intervention with antiproliferative drugs may result in…”
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Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell by Greupink, Rick, Bakker, Hester I., Reker-Smit, Catharina, van Loenen-Weemaes, Anne-miek, Kok, Robbert-Jan, Meijer, Dirk K.F., Beljaars, Leonie, Poelstra, Klaas

“…Hepatic stellate cell (HSC) activation and proliferation are key events in the pathology of liver fibrosis. Inhibiting these parameters, therefore, is a…”
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Potentials and limitations of the low-molecular-weight protein lysozyme as a carrier for renal drug targeting by Haverdings, R F, Haas, M, Greupink, A R, de Vries, P A, Moolenaar, F, de Zeeuw, D, Meijer, D K

“…Selective targeting of drugs to the kidney may enable an increased renal effectiveness combined with a reduction of extrarenal toxicity. Intrarenal delivery to…”
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354 Hepatic stellate cell specific delivery of mycophenolic acid as a strategy to treat liver fibrosis by Greupink, Rick, Bakker, Hester, van Loenen-Weemaes, Anne-Miek, Reker-Smit, Catharina, Meijer, Dirk, Beljaars, Leonie, Poelstra, Klaas

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