Search Results - "Gretch, DR"

Hepatitis C Viral Dynamics In vivo and the Antiviral Efficacy of Interferon-α Therapy by Neumann, Avidan U., Lam, Nancy P., Dahari, Harel, Gretch, David R., Wiley, Thelma E., Layden, Thomas J., Perelson, Alan S.

“…To better understand the dynamics of hepatitis C virus and the antiviral effect of interferon-α-2b (IFN), viral decline in 23 patients during therapy was…”
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Diagnostic tests for hepatitis C by Gretch, D R

“…Diagnostic tests for hepatitis C can be divided into the following two general categories: 1) serological assays that detect antibody to hepatitis C virus…”
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Serum alpha-fetoprotein levels in patients with advanced hepatitis C: Results from the HALT-C Trial by Di Bisceglie, Adrian M., Sterling, Richard K., Chung, Raymond T., Everhart, James E., Dienstag, Jules L., Bonkovsky, Herbert L., Wright, Elizabeth C., Everson, Gregory T., Lindsay, Karen L., Lok, Anna S.F., Lee, William M., Morgan, Timothy R., Ghany, Marc G., Gretch, David R., the HALT-C Trial Group

“…Alpha-fetoprotein (AFP) has been useful in the diagnosis of hepatocellular carcinoma (HCC) but lacks specificity. We assessed serum AFP among patients with…”
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Decreased NK cell frequency in chronic hepatitis C does not affect ex vivo cytolytic killing by MORISHIMA, Chihiro, PASCHAL, Denise M, WANG, Chia C, YOSHIHARA, Christina S, WOOD, Brent L, YEO, Anthony E. T, EMERSON, Scott S, SHUHART, Margaret C, GRETCH, David R

“…Prior studies have suggested that natural killer (NK) cell function might be impaired in chronic hepatitis C virus (HCV) infection. Circulating NK cell…”
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Hepatitis C Virus NS5A Colocalizes with the Core Protein on Lipid Droplets and Interacts with Apolipoproteins by Shi, Stephanie T., Polyak, Stephen J., Tu, Hong, Taylor, Deborah R., Gretch, David R., Lai, Michael M.C.

“…The nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) has been shown to interact with a variety of cellular proteins and implicated in the…”
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Productive Replication of Hepatitis C Virus in Perihepatic Lymph Nodes In Vivo: Implications of HCV Lymphotropism by Pal, Sampa, Sullivan, Daniel G., Kim, Sean, Lai, K. Kay–Yin, Kae, John, Cotler, Scott J., Carithers, Robert L., Wood, Brent L., Perkins, James D., Gretch, David R.

“…Background & Aims: The pathogenesis of chronic hepatitis C is poorly understood. This study examines the ability of hepatitis C virus (HCV) to infect,…”
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Diagnosis and Monitoring of Hepatic Injury. I. Performance Characteristics of Laboratory Tests by Dufour, D. Robert, Lott, John A, Nolte, Frederick S, Gretch, David R, Koff, Raymond S, Seeff, Leonard B

“…To review information on performance characteristics for tests that are commonly used to identify acute and chronic hepatic injury. A MEDLINE search was…”
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Elevated Levels of Interleukin-8 in Serum Are Associated with Hepatitis C Virus Infection and Resistance to Interferon Therapy by Polyak, S J, Khabar, K S, Rezeiq, M, Gretch, D R

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Hepatitis C Virus Replication in Transfected and Serum-Infected Cultured Human Fetal Hepatocytes by Lázaro, Catherine A, Chang, Ming, Tang, Weiliang, Campbell, Jean, Sullivan, Daniel G, Gretch, David R, Corey, Lawrence, Coombs, Robert W, Fausto, Nelson

“…Understanding the pathogenesis of hepatitis C requires the availability of tissue culture models that sustain viral replication and produce infectious…”
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Diagnosis and Monitoring of Hepatic Injury. II. Recommendations for Use of Laboratory Tests in Screening, Diagnosis, and Monitoring by Dufour, D. Robert, Lott, John A, Nolte, Frederick S, Gretch, David R, Koff, Raymond S, Seeff, Leonard B

“…To review information on the use of laboratory tests in screening, diagnosis, and monitoring of acute and chronic hepatic injury. A MEDLINE search was…”
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Hepatitis C Virus Nonstructural 5A Protein Induces Interleukin-8, Leading to Partial Inhibition of the Interferon-Induced Antiviral Response by Polyak, S J, Khabar, K S, Paschal, D M, Ezelle, H J, Duverlie, G, Barber, G N, Levy, D E, Mukaida, N, Gretch, D R

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Use of the AST to platelet ratio index in HCV/HIV co‐infected patients by Singal, A. G., Thomassen, L. V., Gretch, D. R., Shuhart, M. C.

“…Aliment Pharmacol Ther 2011; 33: 566–577 Summary Background  The AST to platelet ratio index (APRI), a non‐invasive marker of liver fibrosis, has not been well…”
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Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation by Gale, Michael, Blakely, Collin M., Kwieciszewski, Bart, Tan, Seng-Lai, Dossett, Michelle, Tang, Norina M., Korth, Marcus J., Polyak, Stephen J., Gretch, David R., Katze, Michael G.

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Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein by Gale, Michael J., Korth, Marcus J., Tang, Norina M., Tan, Seng-Lai, Hopkins, Deborah A., Dever, Thomas E., Polyak, Stephen J., Gretch, David R., Katze, Michael G.

“…Hepatitis C virus (HCV) is the major cause of non-A non-B hepatitis and a leading cause of liver dysfunction worldwide. While the current therapy for chronic…”
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Hepatitis C Virus Dynamics during Natural Infection Are Associated with Long-Term Histological Outcome of Chronic Hepatitis C Disease by Sullivan, Daniel G., Bruden, Dana, Deubner, Heike, McArdle, Susan, Chung, Minjun, Christensen, Carol, Hennessy, Thomas, Homan, Chriss, Williams, James, McMahon, Brian J., Gretch, David R.

“…Background. The long-term dynamics of hepatitis C virus infection and their association with hepatitis C disease are unknown. Methods. Fifty-two…”
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Dose‐dependent acute clearance of hepatitis C genotype 1 virus with interferon alfa by Lam, N P, Neumann, A U, Gretch, D R, Wiley, T E, Perelson, A S, Layden, T J

“…To determine if the clearance of hepatitis C genotype 1 virus (HCV) is dependent on the dose of interferon alfa‐2b (IFN‐α2b), the acute clearance of HCV after…”
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High Rate of Spontaneous Negativity for Hepatitis C Virus RNA after Establishment of Chronic Infection in Alaska Natives by Scott, John D., McMahon, Brian J., Bruden, Dana, Sullivan, Daniel, Homan, Chriss, Christensen, Carol, Gretch, David R.

“…Background. Hepatitis C virus (HCV) leads to chronic infection in 70%–85% of exposed patients. Spontaneous clearance of the virus after chronic infection is…”
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Hepatitis C Virus–Specific Immune Responses and Quasi-Species Variability at Baseline Are Associated with Nonresponse to Antiviral Therapy during Advanced Hepatitis C by Morishima, Chihiro, Polyak, Stephen J, Ray, Ranjit, Doherty, Michael C, Di Bisceglie, Adrian M, Malet, Peter F, Bonkovsky, Herbert L, Sullivan, Daniel G, Gretch, David R, Rothman, Alan L, Koziel, Margaret James, Lindsay, Karen L

“…Pretreatment hepatitis C virus (HCV)–specific lymphoproliferative (LP) responses, neutralizing antibody (NA) responses, intrahepatic cytotoxic T lymphocyte…”
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Intrahepatic Hepatitis C Virus Replication Correlates with Chronic Hepatitis C Disease Severity In Vivo by PAL, Sampa, SHUHART, Margaret C, THOMASSEN, Lisa, EMERSON, Scott S, TAO SU, FEUERBORN, Nathan, KAE, John, GRETCH, David R

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Social Structural and Behavioral Underpinnings of Hyperendemic Hepatitis C Virus Transmission in Drug Injectors by Brewer, Devon D., Hagan, Holly, Sullivan, Daniel G., Muth, Stephen Q., Hough, Eileen S., Feuerborn, Nathan A., Gretch, David R.

“…BackgroundHepatitis C virus (HCV) is hyperendemic in drug injectors, yet social structural and behavioral factors underlying transmission are not well…”
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