Search Results - "Gressner, A M"

Id1 is a critical mediator in TGF-β-induced transdifferentiation of rat hepatic stellate cells by WIERCINSKA, Eliza, WICKERT, Lucia, DOOLEY, Steven, DENECKE, Bernd, SAID, Harun M, HAMZAVI, Jafar, GRESSNER, A. M, THORIKAY, Midori, DIJKE, Peter Ten, MERTENS, Peter R, BREITKOPF, Katja

“…Transforming growth factor (TGF)-beta is critically involved in the activation of hepatic stellate cells (HSCs) that occurs during the process of liver damage,…”
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Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis by Gressner, A M

“…Hepatic stellate cells (HSC) are the major source of extracellular matrix components (ECM), if these precursor cells are activated in areas of…”
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Thrombospondin 1 acts as a strong promoter of transforming growth factor β effects via two distinct mechanisms in hepatic stellate cells by Breitkopf, K, Sawitza, I, Westhoff, J H, Wickert, L, Dooley, S, Gressner, A M

“…Background and aims: Thrombospondin 1 (TSP-1) is an important activator of latent transforming growth factor β (TGF-β) but little is known of the expression…”
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Cytokines and cellular crosstalk involved in the activation of fat-storing cells by GRESSNER, A. M

“…Based on current knowledge a "3-step cascade model of fat-storing cell activation" is suggested, which implies sequential cross-talk between fat-storing cells,…”
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Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF‐β as major players and therapeutic targets by Gressner, A. M., Weiskirchen, R.

“…Hepatic fibrosis is a scarring process that is associated with an increased and altered deposition of extracellular matrix in liver. At the cellular and…”
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Biomarkers of hepatic fibrosis, fibrogenesis and genetic pre‐disposition pending between fiction and reality by Gressner, O.A., Weiskirchen, R., Gressner, A.M.

“…•  Introduction •  Pathways, cells and molecular mediators in liver fibrogenesis •  Classification of biomarkers of fibrosis •  Class I biomarkers of fibrosis…”
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Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis by Kovalenko, E., Tacke, F., Gressner, O. A., Zimmermann, H. W., Lahme, B., Janetzko, A., Wiederholt, T., Berg, T., Müller, T., Trautwein, C., Gressner, A. M., Weiskirchen, R.

“…Clinical and experimental studies have demonstrated that connective‐tissue growth factor (CTGF) expression is increased in fibrotic human liver and…”
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Modulation of transforming growth factor β response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts by Dooley, Steven, Delvoux, Bert, Lahme, Birgit, Mangasser‐Stephan, Kerstin, Gressner, Axel M.

“…Activation of hepatic stellate cells (HSCs) is the key step in liver fibrogenesis. Increased transforming growth factor β (TGF‐β) expression and extracellular…”
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Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis by Herbst, H, Wege, T, Milani, S, Pellegrini, G, Orzechowski, HD, Bechstein, WO, Neuhaus, P, Gressner, AM, Schuppan, D

“…The remodeling of extracellular matrix during chronic liver disease may partially be attributed to altered activity of matrix metalloproteinases and their…”
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Automated CD61 immunoplatelet analysis of thrombocytopenic samples by Kunz, D., Kunz, W. S., Scott, C. S., Gressner, A. M.

“…Revision of the current decision point for prophylactic platelet transfusion in thrombocytopenic patients requires the availability of a method that is able to…”
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Induction of neutrophil-attracting chemokines in transforming rat hepatic stellate cells by Sprenger, H, Kaufmann, A, Garn, H, Lahme, B, Gemsa, D, Gressner, AM

“…BACKGROUND & AIMS: Hepatic stellate cells (HSCs) play a key role in the pathogenesis of liver fibrosis. Immigrating leukocytes can potentiate the progression…”
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Molecular mechanisms of liver fibrogenesis--a homage to the role of activated fat-storing cells by Gressner, A M, Bachem, M G

“…During the last few years, considerable progress has been made in the dissection of cellular and molecular mechanisms of hepatic fibrogenesis. The disease,…”
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TGF-β-mediated hepatocellular apoptosis by rat and human hepatoma cells and primary rat hepatocytes by Gressner, Axel M., Lahme, Birgit, Mannherz, Hans-Georg, Polzar, Bernard

“…Background/Aims: Primary cultures of rat hepatocytes, rat (FAO) and human (HepG2) hepatoma cells were studied by immunocytochemistry for expression of…”
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Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells by Antoine, M., Wirz, W., Tag, C. G., Mavituna, M., Emans, N., Korff, T., Stoldt, V., Gressner, A. M., Kiefer, P.

“…Fibroblast growth factors (FGFs) are important angiogenic growth factors. While basic FGF (FGF2) is well established as a potent inducer of angiogenesis much…”
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Comparative analysis of adenoviral transgene delivery via tail or portal vein into rat liver by Herrmann, J, Abriss, B, van de Leur, E, Weiskirchen, S, Gressner, A. M, Weiskirchen, R

“…The potential indications for gene therapy are expanding continuously. Currently, hepatotropic adenoviruses are useful vector systems for targeting liver in…”
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Upregulation of pleiotrophin expression in rat hepatic stellate cells by PDGF and hypoxia: Implications for its role in experimental biliary liver fibrogenesis by Antoine, M., Tag, C.G., Wirz, W., Borkham-Kamphorst, E., Sawitza, I., Gressner, A.M., Kiefer, P.

“…Pleiotrophin (PTN) is a secretory heparin binding protein with various biological activities including mitogenesis, angiogenesis, and tissue repair after…”
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Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells : a potential mechanism of self perpetuation in liver fibrogenesis by BACHEM, M. G, MEYER, D, MELCHIOR, R, SELL, K.-M, GRESSNER, A. M

“…Rat liver perisinusoidal lipocytes (PL) cultured on uncoated plastic transform spontaneously within 6-10 d to myofibroblastlike cells (MFBlC). Parallel to the…”
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Perisinusoidal lipocytes and fibrogenesis by Gressner, A M

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The up-and-down of hepatic stellate cells in tissue injury: Apoptosis restores cellular homeostasis by Gressner, Axel M.

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Identification of an unconventional nuclear localization signal in human ribosomal protein S2 by Antoine, M., Reimers, K., Wirz, W., Gressner, A.M., Müller, R., Kiefer, P.

“…Ribosomal proteins must be imported into the nucleus after being synthesized in the cytoplasm. Since the rpS2 amino acid sequence does not contain a typical…”
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