Search Results - "Gress, Catherine J"

Growth Plate Compressions and Altered Hematopoiesis in Collagen X Null Mice by Gress, Catherine J., Jacenko, Olena

“…A variable skeleto-hematopoietic phenotype was observed in collagen X null mice which mirrored the defects in transgenic (Tg) mice with dominant interference…”
Get full text

Structure Activity Relationships of 5-, 6-, and 7-Methyl-Substituted Azepan-3-one Cathepsin K Inhibitors by Yamashita, Dennis S, Marquis, Robert W, Xie, Ren, Nidamarthy, Sirishkumar D, Oh, Hye-Ja, Jeong, Jae U, Erhard, Karl F, Ward, Keith W, Roethke, Theresa J, Smith, Brian R, Cheng, H-Y, Geng, Xiaoliu, Lin, Fan, Offen, Priscilla H, Wang, Bing, Nevins, Neysa, Head, Martha S, Haltiwanger, R. Curtis, Narducci Sarjeant, Amy A, Liable-Sands, Louise M, Zhao, Baoguang, Smith, Ward W, Janson, Cheryl A, Gao, Enoch, Tomaszek, Thaddeus, McQueney, Michael, James, Ian E, Gress, Catherine J, Zembryki, Denise L, Lark, Michael W, Veber, Daniel F

“…The syntheses, in vitro characterizations, and rat and monkey in vivo pharmacokinetic profiles of a series of 5-, 6-, and 7-methyl-substituted azepanone-based…”
Get full text

Azepanone-Based Inhibitors of Human Cathepsin L by Marquis, Robert W, James, Ian, Zeng, Jin, Trout, Robert E. Lee, Thompson, Scott, Rahman, Attiq, Yamashita, Dennis S, Xie, Ren, Ru, Yu, Gress, Catherine J, Blake, Simon, Lark, Michael A, Hwang, Shing-Mei, Tomaszek, Thaddeus, Offen, Priscilla, Head, Martha S, Cummings, Maxwell D, Veber, Daniel F

“…The extension of a previously reported cathepsin K azepanone-based inhibitor template to the design and synthesis of potent and selective inhibitors of the…”
Get full text

Chicken Collagen X Regulatory Sequences Restrict Transgene Expression to Hypertrophic Cartilage in Mice by Campbell, Michelle R., Gress, Catherine J., Appleman, Elizabeth H., Jacenko, Olena

“…Collagen X is produced by hypertrophic cartilage undergoing endochondral ossification. Transgenic mice expressing defective collagen X under the control of…”
Get full text

Potent and Selective Cathepsin L Inhibitors Do Not Inhibit Human Osteoclast Resorption in Vitro by James, Ian E., Marquis, Robert W., Blake, Simon M., Hwang, Shing Mei, Gress, Catherine J., Ru, Yu, Zembryki, Denise, Yamashita, Dennis S., McQueney, Michael S., Tomaszek, Thaddeus A., Oh, Hye-Ja, Gowen, Maxine, Veber, Daniel F., Lark, Michael W.

“…Cathepsins K and L are related cysteine proteases that have been proposed to play important roles in osteoclast-mediated bone resorption. To further examine…”
Get full text

Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists by Miller, William H, Manley, Peter J, Cousins, Russell D, Erhard, Karl F, Heerding, Dirk A, Kwon, Chet, Ross, Stephen T, Samanen, James M, Takata, Dennis T, Uzinskas, Irene N, Yuan, Catherine C.K, Haltiwanger, R.Curtis, Gress, Catherine J, Lark, Michael W, Hwang, Shing-Mei, James, Ian E, Rieman, David J, Willette, Robert N, Yue, Tian-Li, Azzarano, Leonard M, Salyers, Kevin L, Smith, Brian R, Ward, Keith W, Johanson, Kyung O, Huffman, William F

“…In our continuing efforts to identify small molecule vitronectin receptor antagonists, we have discovered a series of phenylbutyrate derivatives, exemplified…”
Get full text

Linking Hematopoiesis to Endochondral Skeletogenesis through Analysis of Mice Transgenic for Collagen X by Jacenko, Olena, Roberts, Douglas W., Campbell, Michelle R., McManus, Patricia M., Gress, Catherine J., Tao, Zhuliang

“…Each skeletal element where marrow develops is first defined by a hypertrophic cartilage blueprint. Through programmed tissue substitution, the cartilaginous…”
Get full text

Azepanone-Based Inhibitors of Human and Rat Cathepsin K by Marquis, Robert W, Ru, Yu, LoCastro, Steven M, Zeng, Jin, Yamashita, Dennis S, Oh, Hye-Ja, Erhard, Karl F, Davis, Larry D, Tomaszek, Thaddeus A, Tew, David, Salyers, Kevin, Proksch, Joel, Ward, Keith, Smith, Brian, Levy, Mark, Cummings, Maxwell D, Haltiwanger, R. Curtis, Trescher, Gudrun, Wang, Bing, Hemling, Mark E, Quinn, Chad J, Cheng, H-Y, Lin, Fan, Smith, Ward W, Janson, Cheryl A, Zhao, Baoguang, McQueney, Michael S, D'Alessio, Karla, Lee, Chao-Pin, Marzulli, Antonia, Dodds, Robert A, Blake, Simon, James, Ian E, Gress, Catherine J, Bradley, Brian R, Lark, Michael W, Gowen, Maxine, Veber, Daniel F

“…The synthesis, in vitro activities, and pharmacokinetics of a series of azepanone-based inhibitors of the cysteine protease cathepsin K (EC 3.4.22.38) are…”
Get full text

Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro by James, Ian E., Marquis, Robert W., Blake, Simon M., Hwang, Shing Mei, Gress, Catherine J., Ru, Yu, Zembryki, Denise, Yamashita, Dennis S., McQueney, Michael S., Tomaszek, Thaddeus A., Oh, Hye-Ja, Gowen, Maxine, Veber, Daniel F., Lark, Michael W.

Get full text