Search Results - "Grenier, Jill M."

DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a through the Gadd45 Protein by Tran, Hien, Brunet, Anne, Grenier, Jill M., Datta, Sandeep R., Fornace, Albert J., DiStefano, Peter S., Chiang, Lillian W., Greenberg, Michael E.

“…The signaling pathway from phosphoinositide 3-kinase to the protein kinase Akt controls organismal life-span in invertebrates and cell survival and…”
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Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication by Lee, Margaret S, Lehár, Joseph, Grenier, Jill M, Altmeyer, Ralf, Owens, Christopher M, Borisy, Alexis A, Johansen, Lisa M, Mawhinney, Christina

“…The search for effective Hepatitis C antiviral therapies has recently focused on host sterol metabolism and protein prenylation pathways that indirectly affect…”
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Functional characterization of Narc 1, a novel proteinase related to proteinase K by Naureckiene, Saule, Ma, Linh, Sreekumar, Kodangattil, Purandare, Urmila, Frederick Lo, C, Huang, Ying, Chiang, Lillian W, Grenier, Jill M, Ozenberger, Bradley A, Steven Jacobsen, J, Kennedy, Jeffrey D, DiStefano, Peter S, Wood, Andrew, Bingham, Brendan

“…The NARC 1 gene encodes a novel proteinase K family proteinase. The domain structure of rat Narc 1 resembles that of the subtilisin-like proprotein convertases…”
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A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity by Johansen, Lisa M, DeWald, Lisa Evans, Shoemaker, Charles J, Hoffstrom, Benjamin G, Lear-Rooney, Calli M, Stossel, Andrea, Nelson, Elizabeth, Delos, Sue E, Simmons, James A, Grenier, Jill M, Pierce, Laura T, Pajouhesh, Hassan, Lehár, Joseph, Hensley, Lisa E, Glass, Pamela J, White, Judith M, Olinger, Gene G

“…Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid…”
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An Orchestrated Gene Expression Component of Neuronal Programmed Cell Death Revealed by cDNA Array Analysis by Chiang, Lillian W., Grenier, Jill M., Ettwiller, Laurence, Jenkins, Lorayne P., Ficenec, Dave, Martin, John, Jin, Fenyu, DiStefano, Peter S., Wood, Andrew

“…Programmed cell death (PCD) during neuronal development and disease has been shown to require de novo RNA synthesis. However, the time course and regulation of…”
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PYPAF7, a Novel PYRIN-containing Apaf1-like Protein That Regulates Activation of NF-κB and Caspase-1-dependent Cytokine Processing by Wang, Lin, Manji, Gulam A., Grenier, Jill M., Al-Garawi, Amal, Merriam, Sarah, Lora, Jose M., Geddes, Brad J., Briskin, Michael, DiStefano, Peter S., Bertin, John

“…PYRIN-containing Apaf1-like proteins (PYPAFs) are members of the nucleotide-binding site/leucine-rich repeat (NBS/LRR) family of signal transduction proteins…”
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Proapoptotic effects of NARC 1 (= PCSK9), the gene encoding a novel serine proteinase by Bingham, Brendan, Shen, Ru, Kotnis, Smita, Lo, C. Frederick, Ozenberger, Bradley A., Ghosh, Nivedita, Kennedy, Jeffrey D., Jacobsen, J. Steven, Grenier, Jill M., DiStefano, Peter S., Chiang, Lillian W., Wood, Andrew

“…Background NARC 1/PCSK9 encodes a novel serine proteinase known to play a role in cholesterol homeostasis. NARC 1 mRNA expression in cerebellar granule neurons…”
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Abstract 4765: Drug synergies observed for antibody and toxin components of SAR3419 ADC contribute to overall conjugate efficacy and can be combination drug or tumor cell line dependent by Rickles, Richard J., Giordano, Thomas P., Cotard, Shakira F., Grenier, Jill M., Romanelli, Angela, Cai, Ti

“…Abstract SAR3419, a novel antibody-drug conjugate (ADC), is composed of a humanized monoclonal IgG1 anti-CD19 antibody (huB4) attached by a cleavable linker to…”
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Abstract 1698: Identification of drugs with eribulin combinatorial activity that kill both eribulin-sensitive and eribulin-insensitive tumor cells by Uenaka, Toshimitsu, Rickles, Richard, Funahashi, Yasuhiro, Zhu, Ping, Grenier, Jill M., Steiger, Janine, Zhao, Nanding, Littlefield, Bruce A., Matsui, Junji, Nomoto, Kenichi

“…Abstract Eribulin mesylate, a nontaxane microtubule dynamics inhibitor with a mechanism distinct from most other antitubulin therapeutics, is clinically used…”
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Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-κB and caspase-1 by Grenier, Jill M., Wang, Lin, Manji, Gulam A., Huang, Waan-Jeng, Al-Garawi, Amal, Kelly, Roxanne, Carlson, Adam, Merriam, Sarah, Lora, Jose M., Briskin, Michael, DiStefano, Peter S., Bertin, John

“…PYRIN-containing Apaf-1-like proteins (PYPAFs) are a recently identified family of proteins thought to function in apoptotic and inflammatory signaling…”
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PYPAF7, a Novel PYRIN-containing Apaf1-like Protein That Regulates Activation of NF-κB and Caspase-1-dependent Cytokine Processing by Lin Wang, Gulam A. Manji, Jill M. Grenier, Amal Al-Garawi, Sarah Merriam, Jose M. Lora, Brad J. Geddes, Michael Briskin, Peter S. DiStefano, John Bertin

“…PY RIN-containing A paf 1-like proteins (PYPAFs) are members of the nucleotide-binding site/leucine-rich repeat (NBS/LRR) family of signal transduction…”
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Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1 by Grenier, Jill M, Wang, Lin, Manji, Gulam A, Huang, Waan Jeng, Al-Garawi, Amal, Kelly, Roxanne, Carlson, Adam, Merriam, Sarah, Lora, Jose M, Briskin, Michael, DiStefano, Peter S, Bertin, John

“…PYRIN-containing Apaf-1-like proteins (PYPAFs) are a recently identified family of proteins thought to function in apoptotic and inflammatory signaling…”
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