Preservation of multiple oncogenic human papillomavirus types in recurrences of early-stage cervical cancers

OBJECTIVES: Our purpose was to determine the relationship between human papillomavirus genotypes contained in primary early stage cervical cancers and those contained in the respective recurrences. STUDY DESIGN: Six early-stage cervical cancers that were considered cured by surgical extirpation subs...

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Bibliographic Details
Published in:	American journal of obstetrics and gynecology Vol. 170; no. 5; pp. 1230 - 1233
Main Authors:	Burnett, Alexander F., Grends, Edward C., Willett, Gerr D., Johnson, Jacqueline C., Barter, James F., Barnes, Willard A.
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA Elsevier Inc 01-05-1994 Elsevier
Subjects:	Adult Aged Base Sequence Biological and medical sciences DNA Probes, HPV DNA, Viral - analysis Early-stage cervical cancer Female Female genital diseases Genes, Viral Gynecology. Andrology. Obstetrics human papillomavirus Humans Medical sciences Middle Aged Molecular Sequence Data Neoplasm Recurrence, Local - virology Papillomaviridae - classification Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomavirus Infections - virology Polymerase Chain Reaction Tumor Virus Infections - virology Tumors Uterine Cervical Neoplasms - virology Early-stage cervical cancer polymerase chain reaction human papillomavirus Human Relapse Carcinoma Typing Early phase Exploration Papovaviridae Malignant tumor Uterine cervix Female genital diseases Papillomavirus Virus Human papillomavirus Risk factor Uterine cervix diseases
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Summary:	OBJECTIVES: Our purpose was to determine the relationship between human papillomavirus genotypes contained in primary early stage cervical cancers and those contained in the respective recurrences. STUDY DESIGN: Six early-stage cervical cancers that were considered cured by surgical extirpation subsequently recurred within 21 months of the original surgery. The primary tumors and the recurrences underwent PolYmerase chain reaction for human PaPillomavirus typing with confirmation of types performed by means of diagnostic restriction fragments. RESULTS: All primary tumors and recurrences contained human papillomavirus, with all primary tumors positive for multiple types. The concordance rate between the primary tumors and recurrences for specific types was 73% 11/15. Among the highly onco9enic types 16 and 18 there was 100% concordance between primary and recurrent tumors. CONCLUSIONS: Highly oncogenic types of human PaPillomavirus are preserved between primary tumors and their recurrences in cervical cancers. This further supports the role of oncogenic types in the maintenance of the malignant state and supports the clono9enic nature of cervical cancer recurrence.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9378 1097-6868
DOI:	10.1016/S0002-9378(13)90439-7