Search Results - "Greiner, Dale L."

Humanized Mouse Models of Clinical Disease by Walsh, Nicole C, Kenney, Laurie L, Jangalwe, Sonal, Aryee, Ken-Edwin, Greiner, Dale L, Brehm, Michael A, Shultz, Leonard D

“…Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized mice, have become increasingly important as small, preclinical…”
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Humanized mice in translational biomedical research by Shultz, Leonard D, Ishikawa, Fumihiko, Greiner, Dale L

“…The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity,…”
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Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines by Nostro, M Cristina, Sarangi, Farida, Yang, Chaoxing, Holland, Andrew, Elefanty, Andrew G, Stanley, Edouard G, Greiner, Dale L, Keller, Gordon

“…Human pluripotent stem cells (hPSCs) represent a renewable source of pancreatic beta cells for both basic research and therapeutic applications. Given this…”
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Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice by Vegas, Arturo J, Veiseh, Omid, Gürtler, Mads, Millman, Jeffrey R, Pagliuca, Felicia W, Bader, Andrew R, Doloff, Joshua C, Li, Jie, Chen, Michael, Olejnik, Karsten, Tam, Hok Hei, Jhunjhunwala, Siddharth, Langan, Erin, Aresta-Dasilva, Stephanie, Gandham, Srujan, McGarrigle, James J, Bochenek, Matthew A, Hollister-Lock, Jennifer, Oberholzer, Jose, Greiner, Dale L, Weir, Gordon C, Melton, Douglas A, Langer, Robert, Anderson, Daniel G

“…When encapsulated with alginate derivatives that resist the foreign-body response, human embryonic stem cell–derived beta cells restore long-term normoglycemia…”
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Humanized mice in studying efficacy and mechanisms of PD‐1‐targeted cancer immunotherapy by Wang, Minan, Yao, Li‐Chin, Cheng, Mingshan, Cai, Danying, Martinek, Jan, Pan, Chong‐Xian, Shi, Wei, Ma, Ai‐Hong, Vere White, Ralph W., Airhart, Susan, Liu, Edison T., Banchereau, Jacques, Brehm, Michael A., Greiner, Dale L., Shultz, Leonard D., Palucka, Karolina, Keck, James G.

“…Establishment of an in vivo small animal model of human tumor and human immune system interaction would enable preclinical investigations into the mechanisms…”
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Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates by Doloff, Joshua C., Veiseh, Omid, Vegas, Arturo J., Tam, Hok Hei, Farah, Shady, Ma, Minglin, Li, Jie, Bader, Andrew, Chiu, Alan, Sadraei, Atieh, Aresta-Dasilva, Stephanie, Griffin, Marissa, Jhunjhunwala, Siddharth, Webber, Matthew, Siebert, Sean, Tang, Katherine, Chen, Michael, Langan, Erin, Dholokia, Nimit, Thakrar, Raj, Qi, Meirigeng, Oberholzer, Jose, Greiner, Dale L., Langer, Robert, Anderson, Daniel G.

“…Host recognition and immune-mediated foreign body response to biomaterials can compromise the performance of implanted medical devices. To identify key cell…”
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Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets by Blodgett, David M, Nowosielska, Anetta, Afik, Shaked, Pechhold, Susanne, Cura, Anthony J, Kennedy, Norman J, Kim, Soyoung, Kucukural, Alper, Davis, Roger J, Kent, Sally C, Greiner, Dale L, Garber, Manuel G, Harlan, David M, diIorio, Philip

“…Understanding distinct gene expression patterns of normal adult and developing fetal human pancreatic α- and β-cells is crucial for developing stem cell…”
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AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice by Youngblood, Bradford A, Brock, Emily C, Leung, John, Falahati, Rustom, Bryce, Paul J, Bright, Jessica, Williams, Jason, Shultz, Leonard D, Greiner, Dale L, Brehm, Michael A, Bebbington, Christopher, Tomasevic, Nenad

“…Pathologic accumulation and activation of mast cells and eosinophils are implicated in allergic and inflammatory diseases. Sialic acid-binding…”
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Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations by Farah, Shady, Doloff, Joshua C., Müller, Peter, Sadraei, Atieh, Han, Hye Jung, Olafson, Katy, Vyas, Keval, Tam, Hok Hei, Hollister-Lock, Jennifer, Kowalski, Piotr S., Griffin, Marissa, Meng, Ashley, McAvoy, Malia, Graham, Adam C., McGarrigle, James, Oberholzer, Jose, Weir, Gordon C., Greiner, Dale L., Langer, Robert, Anderson, Daniel G.

“…Implantable medical devices have revolutionized modern medicine. However, immune-mediated foreign body response (FBR) to the materials of these devices can…”
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Overcoming Current Limitations in Humanized Mouse Research by Brehm, Michael A., Shultz, Leonard D., Luban, Jeremy, Greiner, Dale L.

“…Immunodeficient mice engrafted with human cells and tissues have provided an exciting alternative to in vitro studies with human tissues and nonhuman primates…”
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Generation of improved humanized mouse models for human infectious diseases by Brehm, Michael A., Wiles, Michael V., Greiner, Dale L., Shultz, Leonard D.

“…The study of human-specific infectious agents has been hindered by the lack of optimal small animal models. More recently development of novel strains of…”
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Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma by Trabucco, Sally E, Gerstein, Rachel M, Evens, Andrew M, Bradner, James E, Shultz, Leonard D, Greiner, Dale L, Zhang, Hong

“…Approximately 50% of patients with diffuse large B-cell lymphoma (DLBCL) enter long-term remission after standard chemotherapy. Patients with DLBCL who do not…”
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Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection by Sewald, Xaver, Ladinsky, Mark S., Uchil, Pradeep D., Beloor, Jagadish, Pi, Ruoxi, Herrmann, Christin, Motamedi, Nasim, Murrooka, Thomas T., Brehm, Michael A., Greiner, Dale L., Shultz, Leonard D., Mempel, Thorsten R., Bjorkman, Pamela J., Kumar, Priti, Mothes, Walther

“…Dendritic cells can capture and transfer retroviruses in vitro across synaptic cell-cell contacts to uninfected cells, a process called trans-infection…”
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The role of JNK in the development of hepatocellular carcinoma by Das, Madhumita, Garlick, David S, Greiner, Dale L, Davis, Roger J

“…The cJun NH(2)-terminal kinase (JNK) signal transduction pathway has been implicated in the growth of carcinogen-induced hepatocellular carcinoma. However, the…”
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α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes by Brissova, Marcela, Haliyur, Rachana, Saunders, Diane, Shrestha, Shristi, Dai, Chunhua, Blodgett, David M., Bottino, Rita, Campbell-Thompson, Martha, Aramandla, Radhika, Poffenberger, Gregory, Lindner, Jill, Pan, Fong Cheng, von Herrath, Matthias G., Greiner, Dale L., Shultz, Leonard D., Sanyoura, May, Philipson, Louis H., Atkinson, Mark, Harlan, David M., Levy, Shawn E., Prasad, Nripesh, Stein, Roland, Powers, Alvin C.

“…Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of C-peptide long after disease onset but develop an inadequate glucagon…”
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Humanized mouse model of mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis by Bryce, Paul J., PhD, Falahati, Rustom, PhD, Kenney, Laurie L., PhD, Leung, John, BS, Bebbington, Christopher, PhD, Tomasevic, Nenad, PhD, Krier, Rebecca A., MS, Hsu, Chia-Lin, PhD, Shultz, Leonard D., PhD, Greiner, Dale L., PhD, Brehm, Michael A., PhD

“…Background Mast cells are a critical component of allergic responses in humans, and animal models that allow the in vivo investigation of their contribution to…”
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In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery by Bahal, Raman, Ali McNeer, Nicole, Quijano, Elias, Liu, Yanfeng, Sulkowski, Parker, Turchick, Audrey, Lu, Yi-Chien, Bhunia, Dinesh C., Manna, Arunava, Greiner, Dale L., Brehm, Michael A., Cheng, Christopher J., López-Giráldez, Francesc, Ricciardi, Adele, Beloor, Jagadish, Krause, Diane S., Kumar, Priti, Gallagher, Patrick G., Braddock, Demetrios T., Mark Saltzman, W., Ly, Danith H., Glazer, Peter M.

“…The blood disorder, β-thalassaemia, is considered an attractive target for gene correction. Site-specific triplex formation has been shown to induce DNA repair…”
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Human cancer growth and therapy in immunodeficient mouse models by Shultz, Leonard D, Goodwin, Neal, Ishikawa, Fumihiko, Hosur, Vishnu, Lyons, Bonnie L, Greiner, Dale L

“…Since the discovery of the "nude" mouse more than 40 years ago, investigators have attempted to model human tumor growth in immunodeficient mice. Here, we…”
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Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells by Odorico, Jon, Markmann, James, Melton, Douglas, Greenstein, Julia, Hwa, Albert, Nostro, Cristina, Rezania, Alireza, Oberholzer, Jose, Pipeleers, Daniel, Yang, Luhan, Cowan, Chad, Huangfu, Danwei, Egli, Dieter, Ben-David, Uri, Vallier, Ludovic, Grey, Shane T, Tang, Qizhi, Roep, Bart, Ricordi, Camilo, Naji, Ali, Orlando, Giuseppe, Anderson, Daniel G, Poznansky, Mark, Ludwig, Barbara, Tomei, Alice, Greiner, Dale L, Graham, Melanie, Carpenter, Melissa, Migliaccio, Giovanni, D’Amour, Kevin, Hering, Bernhard, Piemonti, Lorenzo, Berney, Thierry, Rickels, Mike, Kay, Thomas, Adams, Ann

“…ABSTRACTBeta cell replacement has the potential to restore euglycemia in patients with insulin-dependent diabetes. Although great progress has been made in…”
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Stress-impaired transcription factor expression and insulin secretion in transplanted human islets by Dai, Chunhua, Kayton, Nora S, Shostak, Alena, Poffenberger, Greg, Cyphert, Holly A, Aramandla, Radhika, Thompson, Courtney, Papagiannis, Ioannis G, Emfinger, Christopher, Shiota, Masakazu, Stafford, John M, Greiner, Dale L, Herrera, Pedro L, Shultz, Leonard D, Stein, Roland, Powers, Alvin C

“…Type 2 diabetes is characterized by insulin resistance, hyperglycemia, and progressive β cell dysfunction. Excess glucose and lipid impair β cell function in…”
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