Recovery of olfactory function in thirteen-day-old rats after olfactory bulb transplantation but not after olfactory bulb ablation

Previous studies have shown recovery of olfactory ability along with reconnectivity of olfactory nerve (ON) following both olfactory bulb (OB) lesions and OB transplants (TX) when performed in newborn rats. The purpose of the present study is to correlate functional recovery with patterns of anatomi...

Full description

Saved in:

Bibliographic Details
Published in:	Brain research Vol. 724; no. 1; pp. 129 - 135
Main Authors:	Evers, Shelley M., Hendricks, Karen R., Kott, Jon N., Lee, Mary E., Gregov, Mark E., Westrum, Lesnick E.
Format:	Journal Article
Language:	English
Published:	London Elsevier B.V 10-06-1996 Amsterdam Elsevier New York, NY
Subjects:	Age Factors Age-related Anesthesia Animals Behavior, Animal - physiology Behavioral recovery Biological and medical sciences Biomarkers - analysis Conditioning (Psychology) - physiology Development. Senescence. Regeneration. Transplantation Female Food Deprivation Fundamental and applied biological sciences. Psychology Male Nerve Tissue Proteins - analysis Neuronal Plasticity - physiology Olfaction Olfactory Bulb - chemistry Olfactory Bulb - surgery Olfactory Bulb - transplantation Olfactory Marker Protein Olfactory system OMP Plasticity Pregnancy Rats Rats, Sprague-Dawley Reinnervatiom Olfactory marker protein Smell - physiology Vertebrates: nervous system and sense organs Behavioral recovery OP TX Reinnervatiom Olfactory marker protein ABL Olfactory system Age-related NOR SEC OMP OB OC OGL Olfaction Plasticity FC PN ON Rat Rodentia Central nervous system Transplantation Ablation Recovery Vertebrata Mammalia Olfactory pathway Olfactory bulb Reinnervation Brain (vertebrata)
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Previous studies have shown recovery of olfactory ability along with reconnectivity of olfactory nerve (ON) following both olfactory bulb (OB) lesions and OB transplants (TX) when performed in newborn rats. The purpose of the present study is to correlate functional recovery with patterns of anatomical reconnectivity in older, postnatal (PN) 13-day-old rats (a possible critical period for plasticity in the system). Reinnervation of olfactory areas was seen in all OB TX animals regardless of the extent of functional recovery. Eight of nineteen animals with OB TXs demonstrated some degree of behavioral recovery. No reinnervation or behavioral recovery of OB lesion animals was observed. At this age, behavioral recovery is dependent upon reconnectivity within the system and transplantation may be required to facilitate this process.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(96)00312-5