Search Results - "Gregory Sorensen, A."

Robust breast cancer detection in mammography and digital breast tomosynthesis using an annotation-efficient deep learning approach by Lotter, William, Diab, Abdul Rahman, Haslam, Bryan, Kim, Jiye G., Grisot, Giorgia, Wu, Eric, Wu, Kevin, Onieva, Jorge Onieva, Boyer, Yun, Boxerman, Jerrold L., Wang, Meiyun, Bandler, Mack, Vijayaraghavan, Gopal R., Gregory Sorensen, A.

“…Breast cancer remains a global challenge, causing over 600,000 deaths in 2018 (ref. 1 ). To achieve earlier cancer detection, health organizations worldwide…”
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Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma by BATCHELOR, Tracy T, MULHOLLAND, Paul, DEGROOT, John, GATTAMANENI, Rao, CHER, Lawrence, ROSENTHAL, Mark, PAYER, Franz, JÜRGENSMEIER, Juliane M, JAIN, Rakesh K, GREGORY SORENSEN, A, XU, John, QI LIU, NEYNS, Bart, VAN DEN BENT, Martin, BURT NABORS, L, CAMPONE, Mario, WICK, Antje, MASON, Warren, MIKKELSEN, Tom, PHUPHANICH, Surasak, ASHBY, Lynn S

“…A randomized, phase III, placebo-controlled, partially blinded clinical trial (REGAL [Recent in in Glioblastoma Alone and With Lomustine]) was conducted to…”
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Dynamic susceptibility contrast MRI measures of relative cerebral blood volume as a prognostic marker for overall survival in recurrent glioblastoma: results from the ACRIN 6677/RTOG 0625 multicenter trial by Schmainda, Kathleen M, Zhang, Zheng, Prah, Melissa, Snyder, Bradley S, Gilbert, Mark R, Sorensen, A Gregory, Barboriak, Daniel P, Boxerman, Jerrold L

“…The study goal was to determine whether changes in relative cerebral blood volume (rCBV) derived from dynamic susceptibility contrast (DSC) MRI are predictive…”
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Imaging pH using the chemical exchange saturation transfer (CEST) MRI: Correction of concomitant RF irradiation effects to quantify CEST MRI for chemical exchange rate and pH by Sun, Phillip Zhe, Sorensen, A. Gregory

“…Chemical exchange saturation transfer (CEST) MRI has been shown capable of detecting dilute labile protons and abnormal tissue glucose/oxygen metabolism, and…”
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Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group by WEN, Patrick Y, MACDONALD, David R, TSIEN, Christina, MIKKELSEN, Tom, WONG, Eric T, CHAMBERLAIN, Marc C, STUPP, Roger, LAMBORN, Kathleen R, VOGELBAUM, Michael A, VAN DEN BENT, Martin J, CHANG, Susan M, REARDON, David A, CLOUGHESY, Timothy F, SORENSEN, A. Gregory, GALANIS, Evanthia, DEGROOT, John, WICK, Wolfgang, GILBERT, Mark R, LASSMAN, Andrew B

“…Currently, the most widely used criteria for assessing response to therapy in high-grade gliomas are based on two-dimensional tumor measurements on computed…”
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Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion by GREGORY SORENSEN, A, EMBLEM, Kyrre E, JAIN, Rakesh K, POLASKOVA, Pavlina, JENNINGS, Dominique, KIM, Heisoog, ANCUKIEWICZ, Marek, WANG, Meiyun, WEN, Patrick Y, IVY, Percy, BATCHELOR, Tracy T

“…The abnormal vasculature of the tumor microenvironment supports progression and resistance to treatment. Judicious application of antiangiogenic therapy may…”
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Toward implementing an MRI-based PET attenuation-correction method for neurologic studies on the MR-PET brain prototype by Catana, Ciprian, van der Kouwe, Andre, Benner, Thomas, Michel, Christian J, Hamm, Michael, Fenchel, Matthias, Fischl, Bruce, Rosen, Bruce, Schmand, Matthias, Sorensen, A Gregory

“…Several factors have to be considered for implementing an accurate attenuation-correction (AC) method in a combined MR-PET scanner. In this work, some of these…”
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Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate by Andronesi, Ovidiu C, Rapalino, Otto, Gerstner, Elizabeth, Chi, Andrew, Batchelor, Tracy T, Cahill, Dan P, Sorensen, A Gregory, Rosen, Bruce R

“…The investigation of metabolic pathways disturbed in isocitrate dehydrogenase (IDH) mutant tumors revealed that the hallmark metabolic alteration is the…”
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Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy by Emblem, Kyrre E, Mouridsen, Kim, Bjornerud, Atle, Farrar, Christian T, Jennings, Dominique, Borra, Ronald J H, Wen, Patrick Y, Ivy, Percy, Batchelor, Tracy T, Rosen, Bruce R, Jain, Rakesh K, Sorensen, A Gregory

“…Measurement of vessel caliber by magnetic resonance imaging (MRI) is a valuable technique for in vivo monitoring of hemodynamic status and vascular…”
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Edema Control by Cediranib, a Vascular Endothelial Growth Factor Receptor–Targeted Kinase Inhibitor, Prolongs Survival Despite Persistent Brain Tumor Growth in Mice by KAMOUN, Walid S, LEY, Carsten D, FUKUMURA, Dai, SORENSEN, A. Gregory, JAIN, Rakesh K, FARRAR, Christian T, DUYVERMAN, Annique M, LAHDENRANTA, Johanna, LACORRE, Delphine A, BATCHELOR, Tracy T, DI TOMASO, Emmanuelle, DUDA, Dan G, MUNN, Lance L

“…Recent clinical trials of antivascular endothelial growth factor (VEGF) agents for glioblastoma showed promising progression-free and overall survival rates…”
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T1- and T2-Dominant Extravasation Correction in DSC-MRI: Part I—Theoretical Considerations and Implications for Assessment of Tumor Hemodynamic Properties by Bjornerud, Atle, Sorensen, A Gregory, Mouridsen, Kim, Emblem, Kyrre E

“…We present a novel contrast agent (CA) extravasation-correction method based on analysis of the tissue residue function for assessment of multiple hemodynamic…”
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Biomarkers of response and resistance to antiangiogenic therapy by Jain, Rakesh K, Duda, Dan G, Willett, Christopher G, Sahani, Dushyant V, Zhu, Andrew X, Loeffler, Jay S, Batchelor, Tracy T, Sorensen, A. Gregory

“…No validated biomarkers currently exist for appropriately selecting cancer patients for antiangiogenic therapy. A number of potential systemic, circulating,…”
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DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational study by Thomalla, Götz, Dr, Cheng, Bastian, MD, Ebinger, Martin, MD, Hao, Qing, MD, Tourdias, Thomas, Prof, Wu, Ona, PhD, Kim, Jong S, Prof, Breuer, Lorenz, MD, Singer, Oliver C, MD, Warach, Steven, Prof, Christensen, Soren, PhD, Treszl, Andras, MSc, Forkert, Nils D, MSc, Galinovic, Ivana, MD, Rosenkranz, Michael, MD, Engelhorn, Tobias, Prof, Köhrmann, Martin, MD, Endres, Matthias, Prof, Kang, Dong-Wha, Prof, Dousset, Vincent, Prof, Sorensen, A Gregory, Prof, Liebeskind, David S, Prof, Fiebach, Jochen B, MD, Fiehler, Jens, Prof, Gerloff, Christian, Prof

“…Summary Background Many patients with stroke are precluded from thrombolysis treatment because the time from onset of their symptoms is unknown. We aimed to…”
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Phase II Study of Cediranib, an Oral Pan–Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Recurrent Glioblastoma by BATCHELOR, Tracy T, DUDA, Dan G, LOUIS, David N, COHEN, Kenneth S, CHEA, Houng, EXARHOPOULOS, Alexis, LOEFFLER, Jay S, MOSES, Marsha A, IVY, Percy, SORENSEN, A. Gregory, WEN, Patrick Y, JAIN, Rakesh K, DI TOMASO, Emmanuelle, ANCUKIEWICZ, Marek, PLOTKIN, Scott R, GERSTNER, Elizabeth, EICHLER, April F, DRAPPATZ, Jan, HOCHBERG, Fred H, BENNER, Thomas

“…Glioblastoma is an incurable solid tumor characterized by increased expression of vascular endothelial growth factor (VEGF). We performed a phase II study of…”
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Hearing Improvement after Bevacizumab in Patients with Neurofibromatosis Type 2 by Plotkin, Scott R, Stemmer-Rachamimov, Anat O, Barker, Fred G, Halpin, Chris, Padera, Timothy P, Tyrrell, Alex, Sorensen, A. Gregory, Jain, Rakesh K, di Tomaso, Emmanuelle

“…After determining that vascular endothelial growth factor (VEGF) was expressed in vestibular schwannomas, the investigators administered bevacizumab, an…”
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Vagus nerve stimulation reduces infarct size in rat focal cerebral ischemia: An unlikely role for cerebral blood flow by Ay, Ilknur, Sorensen, A. Gregory, Ay, Hakan

“…Abstract We sought to investigate the effect of cervical vagus nerve stimulation (VNS) on cerebral blood flow (CBF), infarct volume, and clinical outcome in a…”
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MRI-assisted PET motion correction for neurologic studies in an integrated MR-PET scanner by Catana, Ciprian, Benner, Thomas, van der Kouwe, Andre, Byars, Larry, Hamm, Michael, Chonde, Daniel B, Michel, Christian J, El Fakhri, Georges, Schmand, Matthias, Sorensen, A Gregory

“…Head motion is difficult to avoid in long PET studies, degrading the image quality and offsetting the benefit of using a high-resolution scanner. As a…”
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A Vascular Normalization Index as Potential Mechanistic Biomarker to Predict Survival after a Single Dose of Cediranib in Recurrent Glioblastoma Patients by SORENSEN, A. Gregory, BATCHELOR, Tracy T, DI TOMASO, Emmanuelle, DUDA, Dan G, JAIN, Rakesh K, ZHANG, Wei-Ting, CHEN, Poe-Jou, YEO, Priscilla, MEIYUN WANG, JENNINGS, Dominique, WEN, Patrick Y, LAHDENRANTA, Johanna, ANCUKIEWICZ, Marek

“…Early imaging or blood biomarkers of tumor response are desperately needed to customize antiangiogenic therapy for cancer patients. Anti-vascular endothelial…”
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Investigation of optimizing and translating pH-sensitive pulsed-chemical exchange saturation transfer (CEST) imaging to a 3T clinical scanner by Sun, Phillip Zhe, Benner, Thomas, Kumar, Ashok, Sorensen, A. Gregory

“…Chemical exchange saturation transfer (CEST) MRI provides a sensitive detection mechanism that allows characterization of dilute labile protons usually…”
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Intraoperative visualization of the pyramidal tract by diffusion-tensor-imaging-based fiber tracking by Nimsky, Christopher, Ganslandt, Oliver, Merhof, Dorit, Sorensen, A. Gregory, Fahlbusch, Rudolf

“…Functional neuronavigation allows intraoperative visualization of cortical eloquent brain areas. Major white matter tracts, such as the pyramidal tract, can be…”
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