Search Results - "Gregory, Richard J."

Hypoxia-Inducible Factor-1 Mediates Activation of Cultured Vascular Endothelial Cells by Inducing Multiple Angiogenic Factors by Yamakawa, Midori, Liu, Louis X, Date, Taro, Belanger, Adam J, Vincent, Karen A, Akita, Geoffrey Y, Kuriyama, Takayuki, Cheng, Seng H, Gregory, Richard J, Jiang, Canwen

“…ABSTRACT—Hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of vascular endothelial growth factor (VEGF) and other hypoxia-responsive…”
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Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia-Inducible Factor 1 by Liu, Louis X., Lu, Hsienwie, Luo, Yuxia, Date, Taro, Belanger, Adam J., Vincent, Karen A., Akita, Geoffrey Y., Goldberg, Mark, Cheng, Seng H., Gregory, Richard J., Jiang, Canwen

“…Hypoxia regulates expression of vascular endothelial growth factor (VEGF) by increasing its transcription and by stabilizing its mRNA. Despite the pivotal role…”
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Preclinical Evaluation of IMGC936, a Next Generation Maytansinoid-based Antibody-drug Conjugate Targeting ADAM9-expressing Tumors by Scribner, Juniper A, Hicks, Stuart W, Sinkevicius, Kerstin W, Yoder, Nicholas C, Diedrich, Gundo, Brown, Jennifer G, Lucas, Jacquelynn, Fuller, Megan E, Son, Thomas, Dastur, Anahita, Hooley, Jeff, Espelin, Christopher W, Themeles, Marian, Chen, Francine Z, Li, Ying, Chiechi, Michael, Lee, Jenny, Barat, Bhaswati, Widjaja, Lusiana, Gorlatov, Sergey, Tamura, James, Ciccarone, Valentina, Ab, Olga, McEachem, Kerry A, Koenig, Scott, Westin, Eric H, Moore, Paul A, Chittenden, Thomas, Gregory, Richard J, Bonvini, Ezio, Loo, Deryk

“…A disintegrin and metalloprotease (ADAM) 9 is a member of the ADAM family of multifunctional, multidomain type 1 transmembrane proteins. ADAM9 is overexpressed…”
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Generation of cAMP-Activated Chloride Currents by Expression of CFTR by Anderson, Matthew P., Rich, Devra P., Gregory, Richard J., Smith, Alan E., Welsh, Michael J.

“…Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis. In order to evaluate its function, CFTR was expressed in…”
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Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells by Rich, Devra P, Anderson, Matthew P, Gregory, Richard J, Cheng, Seng H, Paul, Sucharita, Jefferson, Douglas M, McCann, John D, Klinger, Katherine W, Smith, Alan E, Welsh, Michael J

“…The cystic fibrosis transmembrane conductance regulator (CFTR) was expressed in cultured cystic fibrosis airway epithelial cells and Cl- channel activation…”
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Systemic Administration of AAV8-α-galactosidase A Induces Humoral Tolerance in Nonhuman Primates Despite Low Hepatic Expression by Nietupski, Jennifer B, Hurlbut, Gregory D, Ziegler, Robin J, Chu, Qiuming, Hodges, Bradley L, Ashe, Karen M, Bree, Mark, Cheng, Seng H, Gregory, Richard J, Marshall, John, Scheule, Ronald K

“…In mice, liver-restricted expression of lysosomal enzymes from adeno-associated viral serotype 8 (AAV8) vectors results in reduced antibodies to the expressed…”
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Expression and characterization of the cystic fibrosis transmembrane conductance regulator by Gregory, Richard J, Cheng, Seng H, Rich, Devra P, Marshall, John, Paul, Sucharita, Hehir, Kathleen, Ostedgaard, Lynda, Klinger, Katherine W, Welsh, Michael J, Smith, Alan E

“…Cystic fibrosis (CF) is a common lethal genetic disease that manifests itself in airway and other epithelial cells as defective chloride ion absorption and…”
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Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor α/retinoid X receptor by Belanger, Adam J., Luo, Zhengyu, Vincent, Karen A., Akita, Geoffrey Y., Cheng, Seng H., Gregory, Richard J., Jiang, Canwen

“…In response to cellular hypoxia, cardiomyocytes adapt to consume less oxygen by shifting ATP production from mitochondrial fatty acid β-oxidation to…”
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Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1α/VP16 hybrid transcription factor by VINCENT, Karen A, SHYU, Kou-Gi, LUO, Yuxia, MAGNER, Meredith, TIO, Rene A, CANWEN JIANG, GOLDBERG, Mark A, AKITA, Geoffrey Y, GREGORY, Richard J, ISNER, Jeffrey M

“…Background —Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that regulates expression of genes involved in O 2 homeostasis,…”
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Myocardial expression of baculoviral p35 alleviates doxorubicin-induced cardiomyopathy in rats by Date, Taro, Luo, Zhengyu, Yamakawa, Midori, Belanger, Adam J, Scaria, Abraham, Cheng, Seng H, Gregory, Richard J, Mochizuki, Seibu, Jiang, Canwen

“…The clinical use of doxorubicin, one of the most effective antitumor drugs, is limited by its cardiotoxicity, which results in irreversible cardiomyopathy and…”
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AAV2 Vector Harboring a Liver-Restricted Promoter Facilitates Sustained Expression of Therapeutic Levels of α-Galactosidase A and the Induction of Immune Tolerance in Fabry Mice by Ziegler, Robin J, Lonning, Scott M, Armentano, Donna, Li, Chester, Souza, David W, Cherry, Maribeth, Ford, Christine, Barbon, Christine M, Desnick, Robert J, Gao, Guangping, Wilson, James M, Peluso, Richard, Godwin, Simon, Carter, Barrie J, Gregory, Richard J, Wadsworth, Samuel C, Cheng, Seng H

“…The successful application of gene therapy for the treatment of genetic diseases such as Fabry is reliant on the development of vectors that are safe and that…”
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A hypoxic inducible factor-1α hybrid enhances collateral development and reduces vascular leakage in diabetic rats by Kajiwara, Hidetoshi, Luo, Zhengyu, Belanger, Adam J., Urabe, Akihiro, Vincent, Karen A., Akita, Geoffrey Y., Cheng, Seng H., Mochizuki, Seibu, Gregory, Richard J., Jiang, Canwen

“…Background Diabetes mellitus is a common comorbidity of atherosclerosis. Hypoxia‐inducible factor‐1 (HIF‐1) is the master regulator of the angiogenic response…”
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Mutations in CFTR associated with mild-disease-form CI - channels with altered pore properties by Sheppard, David N, Rich, Devra P, Ostedgaard, Lynda S, Gregory, Richard J, Smith, Alan E, Welsh, Michael J

“…The cystic fibrosis transmembrane conductance regulator (CFTR) is a phosphorylation-regulated C1- channel located in the apical membrane of epithelia. The fact…”
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Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis by Yamakawa, Midori, Liu, Louis X, Belanger, Adam J, Date, Taro, Kuriyama, Takayuki, Goldberg, Mark A, Cheng, Seng H, Gregory, Richard J, Jiang, Canwen

“…The hereditary von Hippel-Lindau (VHL) syndrome predisposes sufferers to highly vascularized tumors such as renal clear cell carcinoma (RCC) and central…”
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Demonstration that CFTR is a Chloride Channel by Alteration of its Anion Selectivity by Anderson, Matthew P., Gregory, Richard J., Thompson, Simon, Souza, David W., Paul, Sucharita, Mulligan, Richard C., Smith, Alan E., Welsh, Michael J.

“…Expression of the cystic fibrosis transmembrane conductance regulator (CFTR) generates adenosine 3′,5′-monophosphate (cAMP)-regulated chloride channels,…”
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Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis by Cheng, S H, Gregory, R J, Marshall, J, Paul, S, Souza, D W, White, G A, O'Riordan, C R, Smith, A E

“…The gene associated with cystic fibrosis (CF) encodes a membrane-associated, N-linked glycoprotein called CFTR. Mutations were introduced into CFTR at residues…”
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Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel by Cheng, S H, Rich, D P, Marshall, J, Gregory, R J, Welsh, M J, Smith, A E

“…CFTR, the protein associated with cystic fibrosis, is phosphorylated on serine residues in response to cAMP agonists. Serines 660, 737, 795, and 813 were…”
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Adenovirus-mediated expression of β-adrenergic receptor kinase C-terminus reduces intimal hyperplasia and luminal stenosis of arteriovenous polytetrafluoroethylene grafts in pigs by ZHENGYU LUO, AKITA, Geoffrey Y, DATE, Taro, TRELEAVEN, Christopher, VINCENT, Karen A, WOODCOCK, Denise, CHENG, Seng H, GREGORY, Richard J, CANWEN JIANG

“…Hemodialysis vascular access dysfunction is the single most important cause of morbidity in kidney hemodialysis patients. Failure of an arteriovenous…”
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Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer by Wills, K N, Maneval, D C, Menzel, P, Harris, M P, Sutjipto, S, Vaillancourt, M T, Huang, W M, Johnson, D E, Anderson, S C, Wen, S F

“…We have constructed recombinant human adenoviruses that express wild-type human p53 under the control of either the Ad 2 major late promoter (MLP) or the human…”
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Differential effects of membrane and soluble Fas ligand on cardiomyocytes: role in ischemia/reperfusion injury by Date, Taro, Mochizuki, Seibu, Belanger, Adam J., Yamakawa, Midori, Luo, Zhengyu, Vincent, Karen A., Cheng, Seng H., Gregory, Richard J., Jiang, Canwen

“…Cardiomyocyte apoptosis by Fas ligand (FasL)/Fas signaling is associated with various pathophysiological conditions, such as ischemia/reperfusion injury and…”
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