Search Results - "Gregory, Philip A."

The RNA Binding Protein Quaking Regulates Formation of circRNAs by Conn, Simon J., Pillman, Katherine A., Toubia, John, Conn, Vanessa M., Salmanidis, Marika, Phillips, Caroline A., Roslan, Suraya, Schreiber, Andreas W., Gregory, Philip A., Goodall, Gregory J.

“…Circular RNAs (circRNAs), formed by non-sequential back-splicing of pre-mRNA transcripts, are a widespread form of non-coding RNA in animal cells. However, it…”
Get full text

MicroRNAs as regulators of epithelial-mesenchymal transition by Gregory, Philip A., Bracken, Cameron P., Bert, Andrew G., Goodall, Gregory J.

“…Epithelial-mesenchymal transition (EMT) describes the molecular reprogramming and phenotypic changes involved in the conversion of polarised immotile…”
Get full text

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition by BRACKEN, Cameron P, GREGORY, Philip A, KOLESNIKOFF, Natasha, BERT, Andrew G, JUN WANG, SHANNON, M. Frances, GOODALL, Gregory J

“…Epithelial to mesenchymal transition occurs during embryologic development to allow tissue remodeling and is proposed to be a key step in the metastasis of…”
Get full text

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 by Vadas, Mathew A, Paterson, Emily L, Farshid, Gelareh, Khew-Goodall, Yeesim, Bert, Andrew G, Barry, Simon C, Tsykin, Anna, Goodall, Gregory J, Gregory, Philip A

“…Epithelial to mesenchymal transition (EMT) facilitates tissue remodelling during embryonic development and is viewed as an essential early step in tumour…”
Get full text

Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression by Gibbons, Don L, Lin, Wei, Creighton, Chad J, Rizvi, Zain H, Gregory, Philip A, Goodall, Gregory J, Thilaganathan, Nishan, Du, Liqin, Zhang, Yiqun, Pertsemlidis, Alexander, Kurie, Jonathan M

“…Metastatic disease is a primary cause of cancer-related death, and factors governing tumor cell metastasis have not been fully elucidated. Here, we address…”
Get full text

Mechanisms of vitamin D3 metabolite repression of IgE-dependent mast cell activation by Yip, Kwok-Ho, PhD, Kolesnikoff, Natasha, PhD, Yu, Chunping, BSc(Hons), Hauschild, Nicholas, BSc(Hons), Taing, Houng, BSc(Hons), Biggs, Lisa, BSc(Hons), Goltzman, David, MD, Gregory, Philip A., PhD, Anderson, Paul H., PhD, Samuel, Michael S., PhD, Galli, Stephen J., MD, Lopez, Angel F., PhD, Grimbaldeston, Michele A., PhD

“…Background Mast cells have gained notoriety based on their detrimental contributions to IgE-mediated allergic disorders. Although mast cells express the…”
Get full text

On the rules of engagement for microRNAs targeting protein coding regions by Sapkota, Sunil, Pillman, Katherine A, Dredge, B Kate, Liu, Dawei, Bracken, Julie M, Kachooei, Saba Ataei, Chereda, Bradley, Gregory, Philip A, Bracken, Cameron P, Goodall, Gregory J

“…Abstract MiRNAs post-transcriptionally repress gene expression by binding to mRNA 3′UTRs, but the extent to which they act through protein coding regions (CDS…”
Get full text

MicroRNA-194 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2 by Das, Rajdeep, Gregory, Philip A, Fernandes, Rayzel C, Denis, Iza, Wang, Qingqing, Townley, Scott L, Zhao, Shuang G, Hanson, Adrienne R, Pickering, Marie A, Armstrong, Heather K, Lokman, Noor A, Ebrahimie, Esmaeil, Davicioni, Elai, Jenkins, Robert B, Karnes, R Jeffrey, Ross, Ashley E, Den, Robert B, Klein, Eric A, Chi, Kim N, Ramshaw, Hayley S, Williams, Elizabeth D, Zoubeidi, Amina, Goodall, Gregory J, Feng, Felix Y, Butler, Lisa M, Tilley, Wayne D, Selth, Luke A

“…Serum levels of miR-194 have been reported to predict prostate cancer recurrence after surgery, but its functional contributions to this disease have not been…”
Get full text

Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation by Tang, Yu Hin, Rockstroh, Anja, Sokolowski, Kamil A, Lynam, Layla-Rose, Lehman, Melanie, Thompson, Erik W, Gregory, Philip A, Nelson, Colleen C, Volpert, Marianna, Hollier, Brett G

“…Triple-negative breast cancers (TNBC) have a relatively poor prognosis and responses to targeted therapies. Between 25 and 39% of TNBCs are claudin-low, a…”
Get full text

Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion by Bracken, Cameron P, Li, Xiaochun, Wright, Josephine A, Lawrence, David M, Pillman, Katherine A, Salmanidis, Marika, Anderson, Matthew A, Dredge, B Kate, Gregory, Philip A, Tsykin, Anna, Neilsen, Corine, Thomson, Daniel W, Bert, Andrew G, Leerberg, Joanne M, Yap, Alpha S, Jensen, Kirk B, Khew-Goodall, Yeesim, Goodall, Gregory J

“…The microRNAs of the miR‐200 family maintain the central characteristics of epithelia and inhibit tumor cell motility and invasiveness. Using the Ago‐HITS‐CLIP…”
Get full text

The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice by Yang, Yanan, Ahn, Young-Ho, Gibbons, Don L, Zang, Yi, Lin, Wei, Thilaganathan, Nishan, Alvarez, Cristina A, Moreira, Daniel C, Creighton, Chad J, Gregory, Philip A, Goodall, Gregory J, Kurie, Jonathan M

“…Epithelial tumor cells transit to a mesenchymal state in response to extracellular cues, in a process known as epithelial-to-mesenchymal transition (EMT). The…”
Get full text

Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer by Fernandes, Rayzel C., Toubia, John, Townley, Scott, Hanson, Adrienne R., Dredge, B. Kate, Pillman, Katherine A., Bert, Andrew G., Winter, Jean M., Iggo, Richard, Das, Rajdeep, Obinata, Daisuke, Sandhu, Shahneen, Risbridger, Gail P., Taylor, Renea A., Lawrence, Mitchell G., Butler, Lisa M., Zoubeidi, Amina, Gregory, Philip A., Tilley, Wayne D., Hickey, Theresa E., Goodall, Gregory J., Selth, Luke A.

“…Potent therapeutic inhibition of the androgen receptor (AR) in prostate adenocarcinoma can lead to the emergence of neuroendocrine prostate cancer (NEPC), a…”
Get full text

MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells by Matsushima, Kayoko, Isomoto, Hajime, Yamaguchi, Naoyuki, Inoue, Naoki, Machida, Haruhisa, Nakayama, Toshiyuki, Hayashi, Tomayoshi, Kunizaki, Masaki, Hidaka, Shigekazu, Nagayasu, Takeshi, Nakashima, Masahiro, Ujifuku, Kenta, Mitsutake, Norisato, Ohtsuru, Akira, Yamashita, Shunichi, Korpal, Manav, Kang, Yibin, Gregory, Philip A, Goodall, Gregory J, Kohno, Shigeru, Nakao, Kazuhiko

“…Esophageal squamous cell carcinoma (ESCC) is often diagnosed at later stages until they are incurable. MicroRNA (miR) is a small, non-coding RNA that…”
Get full text

Extensive transcriptional responses are co-ordinated by microRNAs as revealed by Exon-Intron Split Analysis (EISA) by Pillman, Katherine A, Scheer, Kaitlin G, Hackett-Jones, Emily, Saunders, Klay, Bert, Andrew G, Toubia, John, Whitfield, Holly J, Sapkota, Sunil, Sourdin, Laura, Pham, Hoang, Le, Thuc D, Cursons, Joseph, Davis, Melissa J, Gregory, Philip A, Goodall, Gregory J, Bracken, Cameron P

“…Epithelial-mesenchymal transition (EMT) has been a subject of intense scrutiny as it facilitates metastasis and alters drug sensitivity. Although…”
Get full text

Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin–restricted miRNA antagonists of miR-27 by Young, Jennifer A., Ting, Ka Ka, Li, Jia, Moller, Thorleif, Dunn, Louise, Lu, Ying, Lay, Angelina J., Moses, Joshua, Prado-Lourenço, Leonel, Khachigian, Levon M., Ng, Martin, Gregory, Philip A., Goodall, Gregory J., Tsykin, Anna, Lichtenstein, Ilana, Hahn, Christopher N., Tran, Nham, Shackel, Nicholas, Kench, James G., McCaughan, Geoffrey, Vadas, Mathew A., Gamble, Jennifer R.

“…Cellular junctions are essential to the normal functioning of the endothelium and control angiogenesis, tissue leak, and inflammation. From a screen of micro…”
Get full text

MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms by Chi, Lap Hing, Cross, Ryan S. N., Redvers, Richard P., Davis, Melissa, Hediyeh-zadeh, Soroor, Mathivanan, Suresh, Samuel, Monisha, Lucas, Erin C., Mouchemore, Kellie, Gregory, Philip A., Johnstone, Cameron N., Anderson, Robin L.

“…MiR-21 was identified as a gene whose expression correlated with the extent of metastasis of murine mammary tumours. Since miR-21 is recognised as being…”
Get full text

The miR-200-Quaking axis functions in tumour angiogenesis by Gregory, Philip A.

Get full text

GLUCURONIDATION AND THE UDP-GLUCURONOSYLTRANSFERASES IN HEALTH AND DISEASE by Wells, Peter G, Mackenzie, Peter I, Chowdhury, Jayanta Roy, Guillemette, Chantal, Gregory, Philip A, Ishii, Yuji, Hansen, Antony J, Kessler, Fay K, Kim, Perry M, Chowdhury, Namita Roy, Ritter, Joseph K

“…This article is an updated report of a symposium held at the June 2000 annual meeting of the American Society for Pharmacology and Experimental Therapeutics in…”
Get full text

The microRNA-200 family regulates epithelial to mesenchymal transition by Paterson, Emily L, Kolesnikoff, Natasha, Gregory, Philip A, Bert, Andrew G, Khew-Goodall, Yeesim, Goodall, Gregory J

“…Epithelial-mesenchymal transition (EMT) is implicated in metastasis initiation and has recently been shown to be regulated by the miRNA-200 family and miR-205…”
Get full text

Erratum to “RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer” [Semin. Cancer Biol. 102–103 (2024) 4–16] by Bracken, Cameron P., Goodall, Gregory J., Gregory, Philip A.

Get full text