Search Results - "Gregornik, David"

Characterization of complex structural variation in the CYP2D6-CYP2D7-CYP2D8 gene loci using single-molecule long-read sequencing by Turner, Amy J, Derezinski, Ashley D, Gaedigk, Andrea, Berres, Mark E, Gregornik, David B, Brown, Keith, Broeckel, Ulrich, Scharer, Gunter

“…Complex regions in the human genome such as repeat motifs, pseudogenes and structural (SVs) and copy number variations (CNVs) present ongoing challenges to…”
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Sertraline dosing trends in children and adolescents stratified by CYP2C19 genotype by Brown, Jacob T, Gregornik, David B, Jorgenson, Alissa, Watson, Dave, Roiko, Samuel A, Bishop, Jeffrey R

“…Sertraline is a CYP2C19 substrate commonly prescribed to children with anxiety. This medical record review examined dosing trends and treatment discontinuation…”
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Synthesis of major pharmacogenomics pretest counseling themes: a multisite comparison by Wake, Dyson T, Bell, Gillian C, Gregornik, David B, Ho, Teresa T, Dunnenberger, Henry M

“…The accessibility of pharmacogenomic (PGx) testing has grown substantially over the last decade and with it has arisen a demand for patients to be counseled on…”
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Public Attitudes toward Pharmacogenomic Testing and Establishing a Statewide Pharmacogenomics Database in the State of Minnesota by Zhang, Lusi, Jacobson, Pamala A., Johnson, Alyssa N. K., Gregornik, David B., Johnson, Steven G., McCarty, Catherine A., Bishop, Jeffrey R.

“…The clinical adoption and implementation of pharmacogenomics (PGx) beyond academic medical centers remains slow, restricting the general population from…”
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Pediatric pharmacogenomics: challenges and opportunities: on behalf of the Sanford Children’s Genomic Medicine Consortium by Gregornik, David, Salyakina, Daria, Brown, Marilyn, Roiko, Samuel, Ramos, Kenneth

“…The advent of digital, electronic, and molecular technologies has allowed the study of complete genomes. Integrating this information into drug development has…”
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Pharmacogenomics insights into precision pediatric oncology by Ramos, Kristie N., Gregornik, David, Ramos, Kenneth S.

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Pharmacogenomics insights into precision pediatric oncology by Ramos, Kristie N., Gregornik, David, Ramos, Kenneth S.

“…Pharmacogenomic insights provide an opportunity to optimize medication dosing regimens and patient outcomes. However, the potential for interindividual genomic…”
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Implementation of a Clinical Pharmacogenomics Service in a Large Freestanding Pediatric Health System by Paetznick, Courtney, Gregornik, David, Miller, Lane, Olson, Damon, Brown, Jacob

“…As a large, freestanding pediatric health system, Children’s Minnesota is faced with unique challenges and opportunities with pharmacogenomics (PGx)…”
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A clinician’s guide for counseling patients on results of a multigene pharmacogenomic panel by Ho, Teresa T, Bell, Gillian, Gammal, Roseann S, Gregornik, David, Wake, Dyson T, Dunnenberger, Henry M

“…Abstract Purpose This article explores approaches to pharmacogenomic counseling for patients who have undergone multigene panel testing by describing the…”
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Pharmacokinetics of paclitaxel in an anephric patient by WOO, M. H, GREGORNIK, D, SHEARER, P. D, MEYER, W. H, RELLING, M. V

“…To assess the pharmacokinetics of paclitaxel for recurrent Wilms' tumor in an anephric pediatric patient receiving hemodialysis. Paclitaxel was administered at…”
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The Pharmacogenomics Global Research Network Implementation Working Group: global collaboration to advance pharmacogenetic implementation by Cavallari, Larisa H, Hicks, J Kevin, Patel, Jai N, Elchynski, Amanda L, Smith, D Max, Bargal, Salma A, Fleck, Ashley, Aquilante, Christina L, Killam, Shayna R, Lemke, Lauren, Ochi, Taichi, Ramsey, Laura B, Haidar, Cyrine E, Ho, Teresa, El Rouby, Nihal, Monte, Andrew A, Allen, Josiah D, Beitelshees, Amber L, Bishop, Jeffrey R, Bousman, Chad, Campbell, Ronald, Cicali, Emily J, Cook, Kelsey J, Duong, Benjamin, Tsermpini, Evangelia Eirini, Girdwood, Sonya Tang, Gregornik, David B, Grimsrud, Kristin N, Lamb, Nathan, Lee, James C, Lopez, Rocio Ortiz, Mazhindu, Tinashe Adrian, Morris, Sarah A, Nagy, Mohamed, Nguyen, Jenny, Pasternak, Amy L, Petry, Natasha, van Schaik, Ron H N, Schultz, April, Skaar, Todd C, Al Alshaykh, Hana, Stevenson, James M, Stone, Rachael M, Tran, Nam K, Tuteja, Sony, Woodahl, Erica L, Yuan, Li-Chi, Lee, Craig R

“…Pharmacogenetics promises to optimize treatment-related outcomes by informing optimal drug selection and dosing based on an individual's genotype in…”
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Pentamidine for Prophylaxis against Pneumocystis jirovecii Pneumonia in Pediatric Oncology Patients Receiving Immunosuppressive Chemotherapy by Quinn, Melissa, Fannin, J T, Sciasci, Joseph, Bragg, Allison, Campbell, Patrick K, Carias, Delia, Crews, Kristine R, Gregornik, David, Jeha, Sima, Maron, Gabriela, Pauley, Jennifer L, Swanson, Hope D, Wolf, Joshua, Greene, William

“…pneumonia is a life-threatening opportunistic infection in children receiving immunosuppressive chemotherapy. Without prophylaxis, up to 25% of pediatric…”
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Pharmacogenomics education, research and clinical implementation in the state of Minnesota by Bishop, Jeffrey R, Huang, R Stephanie, Brown, Jacob T, Mroz, Pawel, Johnson, Steven G, Allen, Josiah D, Bielinski, Suzette J, England, Julie, Farley, Joel F, Gregornik, David, Giri, Jyothsna, Kroger, Christine, Long, Susie E, Luczak, Tiana, McGonagle, Erin J, Ma, Sisi, Matey, Eric T, Mandic, Pinar K, Moyer, Ann M, Nicholson, Wayne T, Petry, Natasha, Pawloski, Pamala A, Schlichte, Allyson, Schondelmeyer, Stephen W, Seifert, Randall D, Speedie, Marilyn K, Stenehjem, David, Straka, Robert J, Wachtl, Jason, Waring, Stephen C, Ness, Brian Van, Zierhut, Heather A, Aliferis, Constantin, Wolf, Susan M, McCarty, Catherine A, Jacobson, Pamala A

“…Several healthcare organizations across Minnesota have developed formal pharmacogenomic (PGx) clinical programs to increase drug safety and effectiveness…”
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Derivation of new equations to estimate glomerular filtration rate in pediatric oncology patients by Millisor, Vanessa E., Roberts, Jessica K., Sun, Yilun, Tang, Li, Daryani, Vinay M., Gregornik, David, Cross, Shane J., Ward, Deborah, Pauley, Jennifer L., Molinelli, Alejandro, Brennan, Rachel C., Stewart, Clinton F.

“…Background and objective Monitoring renal function is critical in treating pediatric patients, especially when dosing nephrotoxic agents. We evaluated the…”
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The Role of the Pediatric Pharmacist in Precision Medicine and Clinical Pharmacogenomics for Children by Brown, Jacob T, Gregornik, David, Kennedy, Mary Jayne

“…With the initiatives by the National Institutes of Health and the US Food and Drug Administration, pharmacogenomics is transitioning from the laboratory to…”
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Higher Mycophenolic Acid (MPA) Trough Levels Result In Lower Day 100 Severe Acute GVHD Without Increased Toxicity In Double-Unit Cord Blood Transplantation (CBT) Recipients by Harnicar, Stephen J., Ponce, Doris M, Gregornik, David, Mathew, Sherry, Evans, Katherine L, Zheng, Junting, Devlin, Sean, Pozotrigo, Melissa, Scaradavou, Andromachi, Kernan, Nancy A., Adel, Nelly G., Barker, Juliet N

“…Mycophenolate mofetil (MMF) is frequently combined with cyclosporine-A (CSA) as immunosuppression in unrelated donor CBT. Recent evidence suggests that…”
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Renal function after ifosfamide, carboplatin and etoposide (ICE) chemotherapy, nephrectomy and radiotherapy in children with wilms tumour by Daw, Najat C, Gregornik, David, Rodman, John, Marina, Neyssa, Wu, Jianrong, Kun, Larry E, Jenkins, Jesse J, McPherson, Valerie, Wilimas, Judith, Jones, Deborah P

“…Abstract We prospectively evaluated tumour response and renal function in 12 newly diagnosed children with high-risk Wilms tumour receiving ifosfamide,…”
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Association Between Mycophenolic Acid (MPA) Total Serum Trough Levels and Toxicity and Efficacy Outcomes in Cord Blood Transplantation (CBT) Recipients by Harnicar, Stephen, Ponce, Doris, Gregornik, David, Evans, Katherine, Zheng, Junting, Devlin, Sean, Barker, Juliet N

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