Search Results - "Gregoraszczuk, Ewa L."

Review: Polycyclic aromatic hydrocarbons (PAHs)—Action on placental function and health risks in future life of newborns by Drwal, Eliza, Rak, Agnieszka, Gregoraszczuk, Ewa L.

“…Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants, which are released as products of incomplete combustion processes. Harmful effects…”
Get full text

Effects of single and repeated in vitro exposure of three forms of parabens, methyl-, butyl- and propylparabens on the proliferation and estradiol secretion in MCF-7 and MCF-10A cells by Wróbel, Anna, Gregoraszczuk, Ewa Ł.

“…Here, we analyzed the dose- (0.2, 2, 20, 200nM or 2μM) and time- (48, 96, 144 and 196h) dependent activity of a single or repeated exposure of methyl-, butyl-…”
Get full text

Effect of bisphenol-A on the expression of selected genes involved in cell cycle and apoptosis in the OVCAR-3 cell line by Ptak, Anna, Wróbel, Anna, Gregoraszczuk, Ewa L.

“…To support the argument that bisphenol-A (BPA) poses a risk for ovarian cancer, OVCAR-3 cell line was exposed to environmentally relevant concentration of BPA…”
Get full text

Endocrine-Disrupting Chemicals: Some Actions of POPs on Female Reproduction by Gregoraszczuk, Ewa Łucja, Ptak, Anna

“…Persistent organic pollutants (POPs), such as polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), and…”
Get full text

Leptin stimulation of cell cycle and inhibition of apoptosis gene and protein expression in OVCAR-3 ovarian cancer cells by Ptak, Anna, Kolaczkowska, Elzbieta, Gregoraszczuk, Ewa L.

“…The OVCAR-3 cell line expressing the long (ObRb) and short (ObRt) isoforms of leptin receptor mRNA was used to analyze the effect of leptin on the expression…”
Get full text

Maternal High-Fat Diet During Pregnancy and Lactation has Opposite Effects on Gonadal Expression of Leptin and Leptin Receptor in Rat Dams and Their Offspring by Rak, Agnieszka, Hejmej, Anna, Słupecka-Ziemilska, Monika, Woliński, Jaroslaw, Fiedor, Elzbieta, Bilinska, Barbara, Gregoraszczuk, Ewa Ł

“…This study investigated the effect of a high-fat (HF) diet on protein expression of leptin and its receptor in the gonads of dams and their offspring. Female…”
Get more information

Differential accumulation of HCBz and PeCBz in porcine ovarian follicles and their opposing actions on steroid secretion and CYP11, CYP17, 17β-HSD and CYP19 protein expression. A tissue culture approach by Gregoraszczuk, Ewa Ł., Ptak, Anna, Rak-Mardyła, Agnieszka, Falandysz, Jerzy

“…In the current study, we determined in vitro accumulation of hexachlorobenzene (HCBz) and pentachlorobenzene (PeCBz) in porcine ovarian follicles, the effect…”
Get full text

Effects of valproic acid and levetiracetam on viability and cell cycle regulatory genes expression in the OVCAR-3 cell line by Kwiecińska, Patrycja, Taubøll, Erik, Gregoraszczuk, Ewa Ł.

“…Concentration-and time-dependent effects of two antiepileptic drugs (AEDs), levetiracetam (LEV) and valproic acid (VPA), on proliferation, cytotoxicity and…”
Get full text

Effects of levetiracetam and valproate on reproductive endocrine function studied in human ovarian follicular cells by Taubøll, Erik, Gregoraszczuk, Ewa L., Wojtowicz, Anna K., Milewicz, Tomasz

“…Summary Purpose:  Recent animal studies have indicated possible reproductive endocrine effects of levetiracetam (LEV). The aim of the present study was to…”
Get full text

Bisphenol A induces leptin receptor expression, creating more binding sites for leptin, and activates the JAK/Stat, MAPK/ERK and PI3K/Akt signalling pathways in human ovarian cancer cell by Ptak, Anna, Gregoraszczuk, Ewa L.

“…► BPA up-regulating leptin receptor expression in OVCAR-3 cells. ► Leptin and BPA alone stimulated cell proliferation. ► BPA did not potentiate leptin…”
Get full text

Steroid secretion following exposure of ovarian follicular cells to single congeners and defined mixture of polybrominateddibenzoethers (PBDEs), p, p′-DDT and its metabolite p, p′-DDE by Gregoraszczuk, Ewa Ł., Rak, Agnieszka, Kawalec, K., Ropstad, Erik

“…The main objective of the present study was to describe in vitro effects of individual congeners of polybrominateddibenzoethers (PBDEs) (PBDE-47, 99, 100,…”
Get full text

DDT and its metabolite DDE alter steroid hormone secretion in human term placental explants by regulation of aromatase activity by Wójtowicz, Anna K., Milewicz, Tomasz, Gregoraszczuk, Ewa Ł.

“…Placental explants were used to compare the effects of two isomers of DDT (1,1,1,-trichloro-2,2-bis( p-chlorophenyl)ethane), p, p′-DDT and o, p′-DDT and their…”
Get full text

Effects of valproic acid (VPA) and levetiracetam (LEV) on proliferation, apoptosis and hormone secretion of the human choriocarcinoma BeWo cell line by Patrycja, Kwiecińska, Justyna, Wiśniewska, Ewa, Ł. Gregoraszczuk

“…Epilepsy has been associated with poor obstetric outcomes that may be the result of the epilepsy or a direct effect of anti-epileptic drugs on placentation. To…”
Get full text

Induction of cytochrome P450 1A1 in MCF-7 human breast cancer cells by 4-chlorobiphenyl (PCB3) and the effects of its hydroxylated metabolites on cellular apoptosis by Ptak, Anna, Ludewig, Gabriele, Rak, Agnieszka, Nadolna, Weronika, Bochenek, Michał, Gregoraszczuk, Ewa L.

“…Several studies suggest an involvement of PCBs in breast cancer formation, but the results are ambiguous and the mechanisms not clear. We propose that local…”
Get full text

Differential effects of ambient PAH mixtures on cellular and steroidogenic properties of placental JEG-3 and BeWo cells by Drwal, Eliza, Rak, Agnieszka, Gregoraszczuk, Ewa L.

“…[Display omitted] •PAH mixtures had no effect on steroid hormone secretion by placental cell lines in culture.•Canonical AhR pathway of PAHs metabolism in…”
Get full text

Combinatory effects of PBDEs and 17β-estradiol on MCF-7 cell proliferation and apoptosis by Patrycja, Kwiecińska, Anna, Wróbel, Gregoraszczuk, Ewa Ł.

“…In the present work, we analyzed whether polybrominated diphenyl ethers (PBDEs) (47,99,100 and 209) interfere with the effect of 17β-estradiol on the…”
Get full text

The Impact of Endocrine Disruptors on Endocrine Targets by Gregoraszczuk, Ewa Łucja, Kovacevic, Radmila

“…EDCs are a large group of persistent organic pollutants (POPs), such as polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), polychlorinated…”
Get full text

Action of defined mixtures of PCBs, p, p′-DDT and its metabolite p, p′-DDE, on co-culture of porcine theca and granulosa cells: Steroid secretion, cell proliferation and apoptosis by Gregoraszczuk, Ewa L., Ptak, Anna, Karniewska, Magdalena, Ropstad, Erik

“…We recently reported on a stimulatory effect of a mixture of persistent organic pollutants (POPs) extracted from the liver oil of Atlantic cod ( Gadus morhua)…”
Get full text

Direct inhibition of ERK1/2 phosphorylation as a possible mechanism for the antiproliferative action of 3,4-diOH-PCB3 in the MCF-7 cell line by Ptak, Anna, Gut, Patrycja, Błachuta, Małgorzata, Rak, Agnieszka, Gregoraszczuk, Ewa Ł.

“…Our previously published data showed that 260 h of exposure to 3,4-diOH-PCB3 decreased proliferation in the MCF-7 cell line. In the present study, we sought to…”
Get full text

Valproate Inhibits the Conversion of Testosterone to Estradiol and Acts as an Apoptotic Agent in Growing Porcine Ovarian Follicular Cells by Taubøll, Erik, Gregoraszczuk, Ewa L., Kołodziej, Anna, Kajta, Małgorzata, Ropstad, Erik

“…Purpose: Long‐term valproate (VPA) treatment has been associated with hyperandrogenism and polycystic ovaries in women with epilepsy. The exact mechanisms of…”
Get full text