Search Results - "Gregoraszczuk, E. L."

Congener-specific action of PBDEs on steroid secretion, CYP17, 17β-HSD and CYP19 activity and protein expression in porcine ovarian follicles by Karpeta, A., Rak-Mardyła, A., Jerzak, J., Gregoraszczuk, E.L.

“…► PBDEs as endocrine disruptors in the ovary. ► Stimulatory action on testosterone secretion. ► Congeners specific activation of steroidogenic enzymes activity…”
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Activation of the enzymes of phase I (CYP2B1/2) and phase II (SULT1A and COMT) metabolism by 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) in the pig ovary by Karpeta, A., Warzecha, K., Jerzak, J., Ptak, A., Gregoraszczuk, E.L.

“…► We analyzed the activity and expression of enzymes involved in phase I and phase II of BDE-47 metabolism. ► We showed that BDE-47 induce the first phase…”
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Effects of 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) on the enzymes of phase I (CYP2B1/2) and phase II (SULT1A and COMT) metabolism, and differences in the action of parent BDE-47 and its hydroxylated metabolites, 5-OH-BDE-47 and 6-OH-BDE47, on steroid secretion by luteal cells by Gregoraszczuk, E.L, Dobrzanska, G, Karpeta, A

“…Highlights • Dependent on corpus luteum development expression of metabolizing enzymes. • Inhibitory action on CYP2B1/2, but no effect on SULT1A or COMT…”
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Expression of apelin and apelin receptor (APJ) in porcine ovarian follicles and in vitro effect of apelin on steroidogenesis and proliferation through APJ activation and different signaling pathways by Rak, A., Drwal, E., Rame, Ch, Knapczyk-Stwora, K., Słomczyńska, M., Dupont, J., Gregoraszczuk, E.L.

“…Apelin was thought to be an adipocyte-specific hormone, but recent studies indicate a link between apelin and female reproductive function. Using real-time…”
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Superactive human leptin antagonist (SHLA), triple Lan1 and quadruple Lan2 leptin mutein as a promising treatment for human folliculoma by Fiedor, E., Gregoraszczuk, E. L.

“…Purpose There are no data showing a direct correlation between obesity and increased blood leptin levels with folliculoma. Moreover, folliculoma is not the…”
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Compounds of PAH mixtures dependent interaction between multiple signaling pathways in granulosa tumour cells by Zajda, K., Rak, A., Ptak, A., Gregoraszczuk, E.L.

“…[Display omitted] •Composition of PAH mixtures dependent. mechanism of action on CYP1A1 expression.•Activation of AhRR and NFkB in cells exposed for M1 and…”
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Congener-specific accumulation of polychlorinated biphenyls in ovarian follicular wall follows repeated exposure to PCB 126 and PCB 153. Comparison of tissue levels of PCB and biological changes by Gregoraszczuk, E.L., Grochowalski, A., Chrzaszcz, R., Wegiel, M.

“…Objective. Small (SF), medium (MF) and large (LF) preovulatory porcine follicles were isolated and incubated in an Erlenmeyer flask containing 5 ml of medium…”
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Estrogenic and antiestrogenic effect of in vitro treatment of follicular cells with 2,3,7,8-tetrachlorodibenzo- p-dioxin by Grochowalski, A, Chrza̧szcz, R, Pieklo, R, Gregoraszczuk, E.L

“…Objective. Two types of follicular cells from preovulatory ovary were cultured in vitro separately and in co-culture to test difference in…”
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Effect of PCB 126 and PCB 153 on incidence of apoptosis in cultured theca and granulosa cells collected from small, medium and large preovulatory follicles by Gregoraszczuk, E.L, Sowa, M, Kajta, M, Ptak, A, Wójtowicz, A

“…The aim of the presented study was to evaluate the effects of PCB 126 and PCB 153 on granulosa and theca cell apoptosis. Granulosa and theca cells were…”
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Superactive human leptin antagonist reverses leptin-induced excessive progesterone and testosterone secretion in porcine ovarian follicles by blocking leptin receptors by Gregoraszczuk, E L, Rak, A

“…Accumulating evidence indicates that leptin plays an important role in controlling reproductive function. At physiological levels, leptin stimulates…”
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Comparison of accumulation and altered steroid secretion by placental tissue treated with TCDD and natural mixture of PCDDs-PCDFs by Augustowska, K, Gregoraszczuk, E EL, Grochowalski, A, Milewicz, T, Mika, M, Krzysiek, J, Chrzaszcz, R

“…Explants of human placental tissue harvested immediately after expulsion were used to determine differences between accumulation of…”
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Modulatory effect of ghrelin in prepubertal porcine ovarian follicles by Rak, A, Gregoraszczuk, E L

“…Ghrelin is a novel growth hormone-releasing peptide, originally identified in rat stomach as an endogenous ligand of the growth hormone secretagogue receptor…”
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Expression of ghrelin and the ghrelin receptor in different stages of porcine corpus luteum development and the inhibitory effects of ghrelin on progesterone secretion, 3β-hydroxysteroid dehydrogenase (3β-honestly significant difference (HSD)) activity and protein expression by Rak-Mardyła, A, Gregoraszczuk, E.L, Karpeta, A, Duda, M

“…Recent studies have suggested that ghrelin plays a direct role in controlling female reproduction. The aim of the present study was to investigate the mRNA and…”
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ERK 1/2 and PI-3 kinase pathways as a potential mechanism of ghrelin action on cell proliferation and apoptosis in the porcine ovarian follicular cells by Rak-Mardyla, A, Gregoraszczuk, E L

“…Recently, we reported the stimulatory effect of ghrelin on ovarian cell proliferation in parallel with the inhibitory action of ghrelin on cell apoptosis. The…”
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A role for resistin in the ovary during the estrous cycle by Rak-Mardyła, A, Duda, M, Gregoraszczuk, E Ł

“…In a previous study, we showed that resistin expression increased during ovarian follicle development in prepubertal pigs and had direct effects on…”
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Expression of ghrelin and its receptor in porcine ovarian follicles collected from prepubertal and estrous cycle animals by Rak-Mardyla, A, Gregoraszczuk, E L

“…Ghrelin, a hormone predominantly found in the stomach, was described as a factor that controls female reproductive function. Using real time PCR and western…”
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Progesterone-induced secretion of growth hormone, insulin-like growth factor I and prolactin by human breast cancer explants by GREGORASZCZUK, E. L, MILEWICZ, T, KOLODZIEJCZYK, J, KRZYSIEK, J, BASTA, A, SZTEFKO, K, KUREK, S, STACHURA, J

“…The aim of the study was to evaluate the potential of human breast cancer tissue to secrete growth hormone (GH), insulin-like growth factor I (IGF-I) and…”
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Hexachlorobenzene and pentachlorobenzene accumulation, metabolism and effect on steroid secretion and on CYP11A1 and CYP19 expression in cultured human placental tissue by Gregoraszczuk, E.L., Ptak, A., Karpeta, A., Fiedor, E., Wróbel, A., Milewicz, T., Falandysz, J.

“…•HCBz and PeCBz do not accumulate in placental tissue in vitro.•Fast induction of CYP1A1 activity and protein expression in the presence of HCBz, but later…”
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Aryl hydrocarbon receptor (AhR)-linked inhibition of luteal cell progesterone secretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin treated cells by Gregoraszczuk, E L, Zabielny, E, Ochwat, D

“…In this study, we tested firstly, the hypothesis that decrease of progesterone secretion by luteal cells under the influence of…”
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2,3,7,8-Tetrachlorodibenzo-p-dioxin alters follicular steroidogenesis in time- and cell-specific manner by Piekło, R, Grochowalski, A, Gregoraszczuk, E L

“…To show the direct effect of TCDD on ovarian steroidogenesis theca (Tc) and granulosa (Gc) cells were cultured separately or as a co-culture (GT). Cells were…”
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