Search Results - "Gregor Sutcliffe, J."

Molecular profiles of schizophrenia in the CNS at different stages of illness by Narayan, Sujatha, Tang, Bin, Head, Steven R, Gilmartin, Timothy J, Sutcliffe, J. Gregor, Dean, Brian, Thomas, Elizabeth A

“…Abstract Results from clinical and imaging studies provide evidence for changes in schizophrenia with disease progression, however, the underlying molecular…”
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The hypocretins: Setting the arousal threshold by Sutcliffe, J. Gregor, de Lecea, Luis

“…Over a short period in the late 1990s, three groups converged on the discovery of a neuropeptide system, centred in the dorsolateral hypothalamus, that…”
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5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern by HEDLUND, Peter B, HUITRON-RESENDIZ, Salvador, HENRIKSEN, Steven J, SUTCLIFFE, J. Gregor

“…The 5-hydroxytryptamine7 receptor (5-HT7) is implicated in circadian rhythm phase resetting, and 5-HT7 receptor-selective antagonists alter rapid eye movement…”
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The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder by HEDLUND, Peter B, GREGOR SUTCLIFFE, J

“…The 5-HT7 receptor has been suggested as a new putative target for the treatment of neuropsychiatric disorders, especially depression. This hypothesis is based…”
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The hypocretins and sleep by de Lecea, Luis, Sutcliffe, J. Gregor

“…The hypocretins (also called the orexins) are two neuropeptides derived from the same precursor whose expression is restricted to a few thousand neurons of the…”
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Glycolipid and ganglioside metabolism imbalances in Huntington's disease by Desplats, Paula A, Denny, Christine A, Kass, Kristi E, Gilmartin, Tim, Head, Steven R, Sutcliffe, J. Gregor, Seyfried, Thomas N, Thomas, Elizabeth A

“…Abstract We have explored genome-wide expression of genes related to glycobiology in exon 1 transgenic Huntington's disease (HD) mice using a custom-designed…”
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Heterogeneous expression of the triggering receptor expressed on myeloid cells‐2 on adult murine microglia by Schmid, Christoph D., Sautkulis, Lauren N., Danielson, Patria E., Cooper, Judith, Hasel, Karl W., Hilbush, Brian S., Sutcliffe, J. Gregor, Carson, Monica J.

“…Microglial activation is an early and common feature of almost all neuropathologies, including multiple sclerosis, Alzheimer's disease and mechanical injury…”
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Selective deficits in the expression of striatal‐enriched mRNAs in Huntington's disease by Desplats, Paula A., Kass, Kristi E., Gilmartin, Tim, Stanwood, Gregg D., Woodward, Elliott L., Head, Steven R., Sutcliffe, J. Gregor, Thomas, Elizabeth A.

“…We have identified and cataloged 54 genes that exhibit predominant expression in the striatum. Our hypothesis is that such mRNA molecules are likely to encode…”
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Increased CNS Levels of Apolipoprotein D in Schizophrenic and Bipolar Subjects: Implications for the Pathophysiology of Psychiatric Disorders by Thomas, Elizabeth A., Dean, Brian, Pavey, Geoffrey, Sutcliffe, J. Gregor

“…Chronic administration of the atypical antipsychotic drug, clozapine, to rodents has been shown to increase the concentration of apolipoprotein D (apoD) in…”
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RC3/neurogranin, a postsynaptic calpacitin for setting the response threshold to calcium influxes by Gerendasy, D D, Sutcliffe, J G

“…In this review, we attempt to cover the descriptive, biochemical and molecular biological work that has contributed to our current knowledge about…”
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Searching for Interferon-Induced Genes That Inhibit Hepatitis B Virus Replication in Transgenic Mouse Hepatocytes by Wieland, Stefan F, Vega, Raquel G, Müller, Rolf, Evans, Claire F, Hilbush, Brian, Guidotti, Luca G, Sutcliffe, J Gregor, Schultz, Peter G, Chisari, Francis V

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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TOGA: An Automated Parsing Technology for Analyzing Expression of Nearly All Genes by Sutcliffe, J. Gregor, Foye, Pamela E., Erlander, Mark G., Hilbush, Brian S., Bodzin, Leon J., Durham, Jayson T., Hasel, Karl W.

“…We have developed an automated, high-throughput, systematic cDNA display method called TOGA, an acronym for total gene expression analysis. TOGA utilizes 8-nt…”
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Peripheral reduction of β-amyloid is sufficient to reduce brain β-amyloid: Implications for Alzheimer's disease by Sutcliffe, J. Gregor, Hedlund, Peter B., Thomas, Elizabeth A., Bloom, Floyd E., Hilbush, Brian S.

“…Three loci that modify β‐amyloid (Aβ) accumulation and deposition in the brains of a mouse model of Alzheimer's disease have been previously described. One…”
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Differential gene expression in LPS/IFNγ activated microglia and macrophages: in vitro versus in vivo by Schmid, Christoph D, Melchior, Benoit, Masek, Kokoechat, Puntambekar, Shweta S, Danielson, Patria E, Lo, David D, Gregor Sutcliffe, J, Carson, Monica J

“…Two different macrophage populations contribute to CNS neuroinflammation: CNS-resident microglia and CNS-infiltrating peripheral macrophages. Markers…”
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Unique Allosteric Regulation of 5-hydroxytryptamine Receptor-Mediated Signal Transduction by Oleamide by Thomas, Elizabeth A., Carson, Monica J., Neal, Michael J., Sutcliffe, J. Gregor

“…The effects of oleamide, an amidated lipid isolated from the cerebrospinal fluid of sleep-deprived cats, on serotonin receptor-mediated responses were…”
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Antipsychotic drug treatment alters the expression of mRNAs encoding lipid metabolism-related proteins by Thomas, E A, George, R C, Danielson, P E, Nelson, P A, Warren, A J, Lo, D, Gregor Sutcliffe, J

“…Using an automated PCR-based genomics approach, TOtal Gene expression Analysis (TOGA), we have examined gene expression profiles of mouse striatum and frontal…”
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Clozapine increases apolipoprotein D expression in rodent brain: towards a mechanism for neuroleptic pharmacotherapy by Thomas, Elizabeth A., Danielson, Patria E., Nelson, P. Austin, Pribyl, Thomas M., Hilbush, Brian S., Hasel, Karl W., Sutcliffe, J. Gregor

“…In contrast to typical neuroleptic drugs, which have high affinities for dopamine D2 receptors, clozapine binds to multiple neurotransmitter receptors. The…”
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The neurobiology of apolipoproteins in psychiatric disorders by Sutcliffe, J Gregor, Thomas, Elizabeth A

“…A genetic contribution to the transmission of psychiatric disorders has been established and it is now accepted that several genes confer susceptibility to…”
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Novel Isoform of Insulin Receptor Substrate p53/p58 Is Generated by Alternative Splicing in the CRIB/SH3-binding Region by Alvarez, Carlos E., Sutcliffe, J. Gregor, Thomas, Elizabeth A.

“…Insulin receptor substrate p53/p58 (IRSp53) is involved in cytoskeletal dynamics and is a candidate disease sensor in polyglutamine expansion…”
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Not asleep, not quite awake by Sutcliffe, J Gregor, de Lecea, Luis

“…Narcoleptic individuals experience episodes of cataplexy, in which they retain consciousness but have no muscle tone. Consciousness and muscle tone are…”
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