Search Results - "Gregg, Randal K."

Mechanisms of Spatial and Temporal Development of Autoimmune Vitiligo in Tyrosinase-Specific TCR Transgenic Mice by Gregg, Randal K, Nichols, Lisa, Chen, Yiming, Lu, Bao, Engelhard, Victor H

“…Generalized vitiligo is thought to have an autoimmune etiology and has been correlated with the presence of CD8 T cells specific for melanocyte differentiation…”
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Ebola virus secreted glycoprotein decreases the anti-viral immunity of macrophages in early inflammatory responses by Bradley, Jillian H., Harrison, Ametria, Corey, Ashley, Gentry, Nathan, Gregg, Randal K.

“…•EBOV sGP inhibits cytokine production of macrophages but not monocytes.•Polarization of macrophages into M1 and M2 phenotypes are not affected by sGP.•EBOV…”
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Implications of microgravity-induced cell signaling alterations upon cancer cell growth, invasiveness, metastatic potential, and control by host immunity by Gregg, Randal K

“…The human endeavor to venture beyond the orbit of Earth is challenged by both continuous space radiation and microgravity-induced immune dysfunction. If…”
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Model Systems for the Study of Malignant Melanoma by Gregg, Randal K

“…Since the first resection of melanoma by Hunter in 1787, efforts to treat patients with this deadly malignancy have been ongoing. Initial work to understand…”
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Prolonged exposure to simulated microgravity diminishes dendritic cell immunogenicity by Tackett, Nichole, Bradley, Jillian H., Moore, Emily K., Baker, Stefanie H., Minter, Stephanie L., DiGiacinto, Brian, Arnold, Jennifer P., Gregg, Randal K.

“…Immune dysfunction due to microgravity remains a hurdle in the next step of human space exploration. Dendritic cells (DC) represent a critical component of…”
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Simulated microgravity-mediated reversion of murine lymphoma immune evasion by Bradley, Jillian H., Barwick, Shannon, Horn, Gillian Q., Ullrich, Elizabeth, Best, Brianna, Arnold, Jennifer P., Gregg, Randal K.

“…No human has returned to the moon since the end of the Apollo program 47 years ago, however, new missions are planned for an orbital outpost. Space radiation…”
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NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury by Li, Li, Huang, Liping, Sung, Sun-sang J, Lobo, Peter I, Brown, Michael G, Gregg, Randal K, Engelhard, Victor H, Okusa, Mark D

“…Previous work has shown that ischemia-reperfusion (IR) injury (IRI) is dependent on CD4(+) T cells from naive mice acting within 24 h. We hypothesize that NKT…”
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Innocuous IFNγ induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production by Jain, Renu, Tartar, Danielle M., Gregg, Randal K., Divekar, Rohit D., Bell, J. Jeremiah, Lee, Hyun-Hee, Yu, Ping, Ellis, Jason S., Hoeman, Christine M., Franklin, Craig L., Zaghouani, Habib

“…The role of Th17 cells in type I diabetes (TID) remains largely unknown. Glutamic acid decarboxylase (GAD) sequence 206–220 (designated GAD2) represents a…”
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A Narrative Review on the Viability of Osteopathic Manipulative Medicine in Treating Irritable Bowel Syndrome With Constipation (IBS-C) by Basra, Mahi, Patel, Hemangi, Stern-Harbutte, Alison, Lee, David, Gregg, Randal K, Waters, Holly B, Potter, Anna K

“…Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by chronic abdominal pain and alterations in bowel habits, with global…”
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Differential Expression of Homing Receptor Ligands on Tumor-Associated Vasculature that Control CD8 Effector T-cell Entry by Woods, Amber N, Wilson, Ashley L, Srivinisan, Nithya, Zeng, Jianhao, Dutta, Arun B, Peske, J David, Tewalt, Eric F, Gregg, Randal K, Ferguson, Andrew R, Engelhard, Victor H

“…Although CD8 T cells are critical for controlling tumors, how they are recruited and home to primary and metastatic lesions is incompletely understood. We…”
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T cell resistance to activation by dendritic cells requires long-term culture in simulated microgravity by Bradley, Jillian H., Stein, Rachel, Randolph, Brad, Molina, Emily, Arnold, Jennifer P., Gregg, Randal K.

“…•SMG-T cells are more activated by DC than control T cells in static conditions.•IL-2 production by SMG-T cells peaks at 72 h SMG culture but diminishes…”
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Use of the anti-inflammatory cytokine interleukin-11 to reverse HIV-1gp120 repression of a natural killer cell line by Favors, Sheena E., Curd, Lindsay M., Gregg, Randal K.

“…► HIV-1 gp120 represses IFN-γ secretion and cytotoxicity of the NK cell line NK-92MI. ► IL-11 activates STAT-3 in NK-92MI cells. ► Activation of STAT-3 by…”
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IL-4 Utilizes an Alternative Receptor to Drive Apoptosis of Th1 Cells and Skews Neonatal Immunity toward Th2 by Li, Lequn, Lee, Hyun-Hee, Bell, J.Jeremiah, Gregg, Randal K, Ellis, Jason S, Gessner, Andre, Zaghouani, Habib

“…Primary neonatal Th1 cells develop alongside of Th2 upon priming of the newborn but undergo apoptosis upon recall with antigen. These Th1 cells were isolated,…”
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Specific T Regulatory Cells Display Broad Suppressive Functions against Experimental Allergic Encephalomyelitis upon Activation with Cognate Antigen by Yu, Ping, Gregg, Randal K, Bell, J. Jeremiah, Ellis, Jason S, Divekar, Rohit, Lee, Hyun-Hee, Jain, Renu, Waldner, Hanspeter, Hardaway, John C, Collins, Mary, Kuchroo, Vijay K, Zaghouani, Habib

“…To date, very few Ag-based regimens have been defined that could expand T regulatory (Treg) cells to reverse autoimmunity. Additional understanding of Treg…”
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A sudden decline in active membrane-bound TGF-beta impairs both T regulatory cell function and protection against autoimmune diabetes by Gregg, Randal K, Jain, Renu, Schoenleber, Scott J, Divekar, Rohit, Bell, J Jeremiah, Lee, Hyun-Hee, Yu, Ping, Zaghouani, Habib

“…Autoimmunity presumably manifests as a consequence of a shortfall in the maintenance of peripheral tolerance by CD4(+)CD25(+) T regulatory cells (Tregs)…”
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On the role of dendritic cells in peripheral T cell tolerance and modulation of autoimmunity by Legge, Kevin L, Gregg, Randal K, Maldonado-Lopez, Roberto, Li, Lequn, Caprio, Jacque C, Moser, Muriel, Zaghouani, Habib

“…Recently, it has become clear that dendritic cells (DCs) are essential for the priming of T cell responses. However, their role in the maintenance of…”
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IL-10 Diminishes CTLA-4 Expression on Islet-Resident T Cells and Sustains Their Activation Rather Than Tolerance by Gregg, Randal K, Bell, J. Jeremiah, Lee, Hyun-Hee, Jain, Renu, Schoenleber, Scott J, Divekar, Rohit, Zaghouani, Habib

“…IL-10, a powerful anti-Th1 cytokine, has shown paradoxical effects against diabetes. The mechanism underlying such variable function remains largely undefined…”
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Break of Neonatal Th1 Tolerance and Exacerbation of Experimental Allergic Encephalomyelitis by Interference with B7 Costimulation by Bell, J. Jeremiah, Min, Booki, Gregg, Randal K, Lee, Hyun-Hee, Zaghouani, Habib

“…Ig-PLP1 is an Ig chimera expressing proteolipid protein-1 (PLP1) peptide corresponding to aa residues 139-151 of PLP. Newborn mice given Ig-PLP1 in saline on…”
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Interactions of natural killer cells and pancreatic cancer cells in simulated microgravity by Gregg, Randal K, Falwell, Harrison, Bludorn, Grant, Laken, Jordan A, Boos, William F, Arnold, Jennifer P, Bradley, Jillian H

“…Abstract One of the major concerns of long-duration spaceflight is the exposure of astronauts to space radiation and the potential for cancer development…”
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Neonatal Exposure to Antigen Primes the Immune System to Develop Responses in Various Lymphoid Organs and Promotes Bystander Regulation of Diverse T Cell Specificities by Pack, Christopher D, Cestra, Aimee E, Min, Booki, Legge, Kevin L, Li, Lequn, Caprio-Young, Jacque C, Bell, J. Jeremiah, Gregg, Randal K, Zaghouani, Habib

“…Neonatal exposure to Ag has always been considered suppressive for immunity. Recent investigations, however, indicated that the neonatal immune system could be…”
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