Search Results - "Gregerson, D. S."

Oral tolerance in experimental autoimmune uveoretinitis. Distinct mechanisms of resistance are induced by low dose vs high dose feeding protocols by Gregerson, DS, Obritsch, WF, Donoso, LA

“…Studies of oral tolerance in LEW rat models of autoimmune diseases including S-antigen (S-Ag)-mediated experimental autoimmune uveoretinitis (EAU), and myelin…”
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Role of Fas-Fas ligand interactions in the immunorejection of allogeneic mouse corneal transplants by YAMAGAMI, S, KAWASHIMA, H, TSURU, T, YAMAGAMI, H, KAYAGAKI, N, YAGITA, H, OKUMURA, K, GREGERSON, D. S

“…The expression of Fas ligand (FasL) in the eye has been proposed to be an important component of ocular immune privilege. Since the unusually favorable outcome…”
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A new, simple, nonradioactive, nontoxic in vitro assay to monitor corneal endothelial cell viability by Larson, EM, Doughman, DJ, Gregerson, DS, Obritsch, WF

“…This study was designed to determine whether Alamar blue could be used to evaluate corneal endothelial cell viability in vitro. Alamar blue incorporates a…”
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Peptide and protein molecular weight determination by electrophoresis using a high-molarity tris buffer system without urea by Fling, S P, Gregerson, D S

“…Various buffer systems were examined for their ability to resolve and provide molecular weight determinations of proteins and peptides over a wide size range…”
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A new model of proliferative vitreoretinopathy by Frenzel, EM, Neely, KA, Walsh, AW, Cameron, JD, Gregerson, DS

“…To design a new model of proliferative vitreoretinopathy (PVR) that would not rely on the addition of exogenous cells. The release of endogenous cells from…”
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Ex vivo transduction of corneal epithelial progenitor cells using a retroviral vector by Bradshaw, JJ, Obritsch, WF, Cho, BJ, Gregerson, DS, Holland, EJ

“…To transduce corneal epithelial progenitor cells with a reporter gene using a retroviral vector and follow their progeny in vitro and in vivo. Using a…”
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Effects of continuous localized infusion of granulocyte-macrophage colony-stimulating factor and inoculations of irradiated glioma cells on tumor regression by WALLENFRIEDMAN, M. A, CONRAD, J. A, DELABARRE, L, GRAUPMAN, P. C, LEE, G, GARWOOD, M, GREGERSON, D. S, JEAN, W. C, HALL, W. A, LOW, W. C

“…Glioblastoma multiforme (GBM) is a malignant tumor of the central nervous system that directly suppresses immunological defenses in vitro and in vivo. The…”
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S-antigen-specific rat T cell lines recognize peptide fragments of S- antigen and mediate experimental autoimmune uveoretinitis and pinealitis by Gregerson, DS, Obritsch, WF, Fling, SP, Cameron, JD

“…Two S-antigen-specific rat T cell lines expressing the T helper cell surface phenotype (W 3/25+, OX 8-) have been isolated from the spleen and lymph node cells…”
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In vitro unresponsiveness to autologous sequences of the immunopathogenic autoantigen, S-antigen by Fling, SP, Donoso, LA, Gregerson, DS

“…Previous analyses of T cell recognition sites on immunopathogenic neural autoantigens have demonstrated, using LEW rats, the functional dissociation of in…”
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Extravascular albumin concentration of the uvea by Toris, CB, Pederson, JE, Tsuboi, S, Gregerson, DS, Rice, TJ

“…The hypothesis that uveal vessels absorb fluid was tested by measuring the albumin in extravascular uveal tissues and in plasma. From these results the…”
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Identification of a potent new pathogenic site in human retinal S-antigen which induces experimental autoimmune uveoretinitis in LEW rats by Gregerson, D S, Merryman, C F, Obritsch, W F, Donoso, L A

“…Experimental autoimmune uveoretinitis (EAU) is a T cell-mediated autoimmune disease of the eye which can be induced in LEW rats by immunization with either…”
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Differential APC Requirements of Self- and Nonself-Reactive T Cells and T Cell Hybridomas Specific for Retinal S-Antigen by Prasad, Shiv A, Fling, Steven P, Gregerson, Dale S

“…Autoreactive T cell hybridomas specific for pathogenic peptides of retinal S-Ag require a novel radiosensitive APC activity for IL-2 secretion that is distinct…”
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Epitopes and idiotypes in experimental autoimmune uveitis: a review by Dua, H S, Abrams, M, Barrett, J A, Gregerson, D S, Forrester, J V, Donoso, L A

“…Retinal S-antigen (SAg) and interphotoreceptor retinol-binding protein (IRBP) induced experimental autoimmune uveitis (EAU) and experimental autoimmune…”
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Identification of T cell recognition sites in S-antigen: dissociation of proliferative and pathogenic sites by Gregerson, D S, Fling, S P, Obritsch, W F, Merryman, C F, Donoso, L A

“…Experimental autoimmune uveoretinitis (EAU) is a predominantly CD4+ T cell-mediated autoimmune inflammatory disease of the retina and uveal tract of the eye…”
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Preparation, isolation, and immunochemical studies of the cyanogen bromide peptides from a retinal photoreceptor cell autoantigen, S- antigen by Gregerson, DS, Putterman, GJ

“…Purified bovine retinal S-antigen (50,000 m.w.) was treated with cyanogen bromide, producing seven major and several minor fragments. Six of the major and one…”
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Unresponsiveness to self-peptides of S-antigen in EAU: an overview of recent results by Gregerson, D S, Fling, S P, Donoso, L A, Gold, D P

“…Several observations in the characterization of EAU are examined. First, sequences of heterologous S-Ag (bovine S-Ag in LEW rats) which induce strong in vitro…”
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Inhibition of experimental autoimmune uveoretinitis by oral administration of S-antigen and synthetic peptides by Vrabec, T R, Gregerson, D S, Dua, H S, Donoso, L A

“…S-Antigen, a photoreceptor cell protein, is highly efficient in inducing experimental autoimmune uveoretinitis (EAU), a severe inflammation of the uveal tract…”
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APC derived from donor splenocytes support retinal autoimmune disease in allogeneic recipients by Gregerson, Dale S., Kawashima, Hidetoshi

“…T cell adoptive transfer models of autoimmune disease have been used in conjunction with radiation/bone marrow chimeras to define the minimal requirements for…”
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Induction of immunotolerance in rats by intratesticular administration of an eicosapeptide of bovine S-antigen by Ren, J, Singh, A K, Gregerson, D S, Shichi, H

“…Immunization of albino LEW rats with a retinal soluble antigen (S-antigen) induces experimental autoimmune uveoretinitis (EAU) which shows clinical features…”
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Resting CD8 T cells recognize β‐galactosidase expressed in the immune‐privileged retina and mediate autoimmune disease when activated by McPherson, Scott W., Yang, Jing, Chan, Chi‐Chao, Dou, Chunzhi, Gregerson, Dale S.

“…Summary Although the expression of class II major histocompatibility complex (MHC) in retina is extremely low, it is an established fact that activated CD4 T…”
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