Search Results - "Gregers, Tone F."

Unraveling the evolution of the Atlantic cod's (Gadus morhua L.) alternative immune strategy by Malmstrøm, Martin, Jentoft, Sissel, Gregers, Tone F, Jakobsen, Kjetill S

“…Genes encoding the major histocompatibility complex (MHC) have been thought to play a vital role in the adaptive immune system in all vertebrates. The…”
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Differential regulation of Rab GTPase expression in monocyte-derived dendritic cells upon lipopolysaccharide activation: a correlation to maturation-dependent functional properties by Berg-Larsen, Axel, Landsverk, Ole J B, Progida, Cinzia, Gregers, Tone F, Bakke, Oddmund

“…The regulation of Rab expression to modulate cellular function has recently been proposed. Dendritic cells are a prototypic example of cells that drastically…”
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EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol by Slominska-Wojewodzka, Monika, Gregers, Tone F, Wälchli, Sébastien, Sandvig, Kirsten

“…The plant toxin ricin is transported retrogradely from the cell surface to the endoplasmic reticulum (ER) from where the enzymatically active part is…”
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BiP negatively affects ricin transport by Gregers, Tone F, Skånland, Sigrid S, Wälchli, Sébastien, Bakke, Oddmund, Sandvig, Kirsten

“…The AB plant toxin ricin binds both glycoproteins and glycolipids at the cell surface via its B subunit. After binding, ricin is endocytosed and then…”
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Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions by Solbakken, Monica H., Tørresen, Ole K., Nederbragt, Alexander J., Seppola, Marit, Gregers, Tone F., Jakobsen, Kjetill S., Jentoft, Sissel

“…Genome sequencing of the teleost Atlantic cod demonstrated loss of the Major Histocompatibility Complex (MHC) class II, an extreme gene expansion of MHC class…”
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The fusion of early endosomes induces molecular-motor-driven tubule formation and fission by Skjeldal, Frode M, Strunze, Sten, Bergeland, Trygve, Walseng, Even, Gregers, Tone F, Bakke, Oddmund

“…Organelles in the endocytic pathway interact and communicate through the crucial mechanisms of fusion and fission. However, any specific link between fusion…”
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Misdirection of endosomal trafficking mediated by herpes simplex virus–encoded glycoprotein B by Niazy, Naima, Temme, Sebastian, Bocuk, Derya, Giesen, Carmen, König, Angelika, Temme, Nadine, Ziegfeld, Angelique, Gregers, Tone F., Bakke, Oddmund, Lang, Thorsten, Eis‐Hübinger, Anna M., Koch, Norbert

“…Herpes simplex virus (HSV)–encoded glycoprotein B (gB) is the most abundant protein in the viral envelope and promotes fusion of the virus with the cellular…”
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Uncoating ATPase Hsc70 is Recruited by Invariant Chain and Controls the Size of Endocytic Compartments by Lagaudriére-Gesbert, Cécile, Newmyer, Sherri L., Gregers, Tone F., Bakke, Oddmund, Ploegh, Hidde L.

“…Targeting of class II major histocompatibility complex molecules to endocytic compartments is mediated by their association with the invariant chain (li)…”
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Disentangling the immune response and host-pathogen interactions in Francisella noatunensis infected Atlantic cod by Solbakken, Monica Hongrø, Jentoft, Sissel, Reitan, Trond, Mikkelsen, Helene, Gregers, Tone F., Bakke, Oddmund, Jakobsen, Kjetill S., Seppola, Marit

“…The genetic repertoire underlying teleost immunity has been shown to be highly variable. A rare example is Atlantic cod and its relatives Gadiformes that lacks…”
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A mutant human IgG molecule with only one C1q binding site can activate complement and induce lysis of target cells by Michaelsen, Terje E., Thommesen, John E., Ihle, Oistein, Gregers, Tone F., Sandin, Randi H., Brekke, Ole Henrik, Sandlie, Inger

“…There are potentially two binding sites for C1q on IgG, one on each CH2 domain of the gamma heavy chains, close to the lower hinge region. It is not clear…”
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The cytoplasmic tail of invariant chain modulates antigen processing and presentation by Gregers, Tone F., Nordeng, Tommy W., Birkeland, Hanne C. G., Sandlie, Inger, Bakke, Oddmund

“…The MHC class II‐associated invariant chain (Ii) has several important functions in antigen presentation. In this study, we have examined the effect of Iip33…”
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Invariant chain as a vehicle to load antigenic peptides on human MHC class I for cytotoxic T‐cell activation by Wälchli, Sébastien, Kumari, Shraddha, Fallang, Lars‐Egil, Sand, Kine M. K., Yang, Weiwen, Landsverk, Ole J. B., Bakke, Oddmund, Olweus, Johanna, Gregers, Tone F.

“…Protective T‐cell responses depend on efficient presentation of antigen (Ag) in the context of major histocompatibility complex class I (MHCI) and class II…”
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Invariant chain increases the half-life of MHC II by delaying endosomal maturation by Landsverk, Ole J B, Barois, Nicolas, Gregers, Tone F, Bakke, Oddmund

“…Mounting adaptive immune responses requires the cell surface expression of major histocompatibility class II molecules (MHC II) loaded with antigenic peptide…”
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Correction: Unraveling the Evolution of the Atlantic Cod’s (Gadus morhua L.) Alternative Immune Strategy by Malmstrøm, Martin, Jentoft, Sissel, Gregers, Tone F., Jakobsen, Kjetill S.

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The human‐specific invariant chain isoform Iip35 modulates Iip33 trafficking and function by Sand, Kine Marita, Landsverk, Ole J B, Berg‐Larsen, Axel, Bakke, Oddmund, Gregers, Tone F

“…The invariant chain (Ii) is a multifunctional protein, which has an essential role in the assembly and transport of major histocompatibility complex class II…”
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The Mitogen-activated protein kinase p38 links Shiga Toxin-dependent signaling and trafficking by Wälchli, Sébastien, Skånland, Sigrid S, Gregers, Tone F, Lauvrak, Silje U, Torgersen, Maria L, Ying, Ming, Kuroda, Shun'ichi, Maturana, Andrés, Sandvig, Kirsten

“…Shiga toxin (Stx) binds to the cell, and it is transported via endosomes and the Golgi apparatus to the endoplasmic reticulum and cytosol, where it exerts its…”
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The cytoplasmic tail of invariant chain regulates endosome fusion and morphology by Nordeng, Tommy W, Gregers, Tone F, Kongsvik, Thomas Lasker, Méresse, Stéphane, Gorvel, Jean-Pierre, Jourdan, Fabrice, Motta, Andrea, Bakke, Oddmund

“…The major histocompatibility complex class II associated invariant chain (Ii) has been shown to inhibit endocytic transport and to increase the size of…”
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The genome sequence of Atlantic cod reveals a unique immune system by Star, Bastiaan, Nederbragt, Alexander J., Jentoft, Sissel, Grimholt, Unni, Malmstrøm, Martin, Gregers, Tone F., Rounge, Trine B., Paulsen, Jonas, Solbakken, Monica H., Sharma, Animesh, Wetten, Ola F., Lanzén, Anders, Winer, Roger, Knight, James, Vogel, Jan-Hinnerk, Aken, Bronwen, Andersen, Øivind, Lagesen, Karin, Tooming-Klunderud, Ave, Edvardsen, Rolf B., Tina, Kirubakaran G., Espelund, Mari, Nepal, Chirag, Previti, Christopher, Karlsen, Bård Ove, Moum, Truls, Skage, Morten, Berg, Paul R., Gjøen, Tor, Kuhl, Heiner, Thorsen, Jim, Malde, Ketil, Reinhardt, Richard, Du, Lei, Johansen, Steinar D., Searle, Steve, Lien, Sigbjørn, Nilsen, Frank, Jonassen, Inge, Omholt, Stig W., Stenseth, Nils Chr, Jakobsen, Kjetill S.

“…Cod goes its own way on immunity The genome of the Atlantic cod has been sequenced, and genomic analysis reveals an immune system that differs significantly…”
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MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs: implications for T cell activation by Gregers, Tone F., Fleckenstein, Burkhard, Vartdal, Frode, Roepstorff, Peter, Bakke, Oddmund, Sandlie, Inger

“…CD4+ T cells recognize peptides presented on the cell surface of antigen presenting cells in the MHC class II context. The biosynthesis and transport of MHC…”
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Recombinant antibodies as carrier proteins for sub-unit vaccines: influence of mode of fusion on protein production and T-cell activation by Eidem, Janne K, Rasmussen, Ingunn B, Lunde, Elin, Gregers, Tone F, Rees, Anthony R, Bogen, Bjarne, Sandlie, Inger

“…A major objective in development of vaccines is the design of sub-unit vaccines with the ability to induce strong T-cell responses. For this purpose, T-cell…”
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