Search Results - "Greer, Susanna F"

Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance by Cacan, Ercan, Ali, Mourad W, Boyd, Nathaniel H, Hooks, Shelley B, Greer, Susanna F

“…RGS10 is an important regulator of cell survival and chemoresistance in ovarian cancer. We recently showed that RGS10 transcript expression is suppressed…”
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Proteolytic and non-proteolytic roles of ubiquitin and the ubiquitin proteasome system in transcriptional regulation by Bhat, Kavita P., Greer, Susanna F.

“…The ubiquitin proteasome system (UPS) regulates perhaps the most intriguing balance in all of biology: how cells control protein function and malfunction in…”
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Dysregulated recruitment of the histone methyltransferase EZH2 to the class II transactivator (CIITA) promoter IV in breast cancer cells by Truax, Agnieszka D, Thakkar, Meghna, Greer, Susanna F

“…One mechanism frequently utilized by tumor cells to escape immune system recognition and elimination is suppression of cell surface expression of Major…”
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Metastatic melanoma cells evade immune detection by silencing STAT1 by Osborn, JoDi Lynn, Greer, Susanna F

“…Transcriptional activation of major histocompatibility complex (MHC) I and II molecules by the cytokine, interferon γ (IFN-γ), is a key step in cell-mediated…”
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Polycomb recruitment at the Class II transactivator gene by Boyd, Nathaniel H., Morgan, Julie E., Greer, Susanna F.

“…[Display omitted] •Epigenetic mechanisms behind CIITA gene inducibility are poorly described.•YY1 and JARID2 are binding partners with EZH2 and influence PRC2…”
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Combination Treatment with Sublethal Ionizing Radiation and the Proteasome Inhibitor, Bortezomib, Enhances Death-Receptor Mediated Apoptosis and Anti-Tumor Immune Attack by Cacan, Ercan, Spring, Alexander M, Kumari, Anita, Greer, Susanna F, Garnett-Benson, Charlie

“…Sub-lethal doses of radiation can modulate gene expression, making tumor cells more susceptible to T-cell-mediated immune attack. Proteasome inhibitors…”
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Transcriptional suppression, DNA methylation, and histone deacetylation of the regulator of G-protein signaling 10 (RGS10) gene in ovarian cancer cells by Ali, Mourad W, Cacan, Ercan, Liu, Yuying, Pierce, Jennifer Young, Creasman, William T, Murph, Mandi M, Govindarajan, Rajgopal, Eblen, Scott T, Greer, Susanna F, Hooks, Shelley B

“…RGS10 regulates ovarian cancer cell growth and survival, and RGS10 expression is suppressed in cell models of ovarian cancer chemoresistance. However, the…”
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Pulling a Ligase out of a ＂HAT＂: pCAF Mediates Ubiquitination of the Class II Transactivator by Morgan, Julie E., Greer, Susanna F.

“…The Class II Transactivator (CIITA) is essential to the regulation of Major Histocompatibility Class II (MHC II) genes transcription. As the “master regulator”…”
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Nonproteolytic roles of 19S ATPases in transcription of CIITApIV genes by Maganti, Nagini, Moody, Tomika D, Truax, Agnieszka D, Thakkar, Meghna, Spring, Alexander M, Germann, Markus W, Greer, Susanna F

“…Accumulating evidence shows the 26S proteasome is involved in the regulation of gene expression. We and others have demonstrated that proteasome components…”
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Regulation of Acetylation at the Major Histocompatibility Complex Class II Proximal Promoter by the 19S Proteasomal ATPase Sug1 by Koues, Olivia I., Dudley, R. Kyle, Truax, Agnieszka D., Gerhardt, Dawson, Bhat, Kavita P., McNeal, Sam, Greer, Susanna F.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Early epigenetic events regulate the adaptive immune response gene CIITA by Mehta, Ninad T., Truax, Agnieszka D., Boyd, Nathaniel H., Greer, Susanna F.

“…Precise regulation of Major Histocompatibility class II (MHC II) genes plays important roles in initiation, propagation and termination of adaptive immune…”
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The class II transactivator (CIITA) is regulated by post-translational modification cross-talk between ERK1/2 phosphorylation, mono-ubiquitination and Lys63 ubiquitination by Morgan, Julie E, Shanderson, Ronald L, Boyd, Nathaniel H, Cacan, Ercan, Greer, Susanna F

“…The class II transactivator (CIITA) is known as the master regulator for the major histocompatibility class II (MHC II) molecules. CIITA is dynamically…”
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Enhancement of CIITA transcriptional function by ubiquitin by Ting, Jenny P-Y, Greer, Susanna F, Zika, Eleni, Conti, Brian, Zhu, Xin-Sheng

“…Although increasing evidence indicates that there is a direct link between ubiquitination and mono-ubiquitination and transcription in yeast, this link has not…”
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Blueprint for cancer research: Critical gaps and opportunities by Elmore, Lynne W., Greer, Susanna F., Daniels, Elvan C., Saxe, Charles C., Melner, Michael H., Krawiec, Ginger M., Cance, William G., Phelps, William C.

“…We are experiencing a revolution in cancer. Advances in screening, targeted and immune therapies, big data, computational methodologies, and significant new…”
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Histone Deacetylase 1/mSin3A Disrupts Gamma Interferon-Induced CIITA Function and Major Histocompatibility Complex Class II Enhanceosome Formation by Zika, Eleni, Greer, Susanna F., Zhu, Xin-Sheng, Ting, Jenny P.-Y.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The 19S proteasome positively regulates histone methylation at cytokine inducible genes by Koues, Olivia I., Dudley, R. Kyle, Mehta, Ninad T., Greer, Susanna F.

“…Studies indicate that the 19S proteasome functions in the epigenetic regulation of transcription. We have shown that as in yeast, components of the 19S…”
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Native Human Antibody to Shr Promotes Mice Survival After Intraperitoneal Challenge With Invasive Group A Streptococcus by Chatterjee, Nilanjana, Huang, Ya-Shu, Lyles, Kristin V, Morgan, Julie E, Kauvar, Lawrence M, Greer, Susanna F, Eichenbaum, Zehava

“…Abstract Background A vaccine against group A Streptococcus (GAS) has been actively pursued for decades. The surface receptor Shr is vital in GAS heme uptake…”
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Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity by Alqinyah, Mohammed, Maganti, Nagini, Ali, Mourad W, Yadav, Ruchi, Gao, Mei, Cacan, Ercan, Weng, Han-Rong, Greer, Susanna F, Hooks, Shelley B

“…RGS10 has emerged as a key regulator of proinflammatory cytokine production in microglia, functioning as an important neuroprotective factor. Although RGS10 is…”
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Radiation-induced modulation of immunogenic genes in tumor cells is regulated by both histone deacetylases and DNA methyltransferases by CACAN, ERCAN, GREER, SUSANNA F, GARNETT-BENSON, CHARLIE

“…Radiation treatment is a pivotal therapy for several cancer types, including colorectal cancer. It has been shown that sublethal doses of radiation modulate…”
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Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation by Koues, Olivia I, Mehta, Ninad T, Truax, Agnieszka D, Dudley, R Kyle, Brooks, Jeanne K, Greer, Susanna F

“…Studies indicate that the 19S proteasome contributes to chromatin reorganization, independent of the role the proteasome plays in protein degradation. We have…”
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