Search Results - "Greer, P A"

Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair by Redpath, G M I, Woolger, N, Piper, A K, Lemckert, F A, Lek, A, Greer, P A, North, K N, Cooper, S T

“…Dysferlin and calpain are important mediators of the emergency response to repair plasma membrane injury. Our previous research revealed that membrane injury…”
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Corrigendum to “Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress” [Biochim. Biophy.Acta 1862 (11): 2023-2033] by Li, S, Zhang, L, Ni, R, Cao, T, Zheng, D, Xiong, S, Greer, PA, Fan, GC, Peng, T

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v-Src-Induced Modulation of the Calpain-Calpastatin Proteolytic System Regulates Transformation by Carragher, N. O., Westhoff, M. A., Riley, D., Potter, D. A., Dutt, P., Elce, J. S., Greer, P. A., Frame, M. C.

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Ceramide triggers an NF-κB-dependent survival pathway through calpain by Demarchi, F, Bertoli, C, Greer, P A, Schneider, C

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Absence of Fer protein tyrosine kinase exacerbates endotoxin induced intestinal epithelial barrier dysfunction in vivo by Qi, W, Ebbert, K V J, Craig, A W B, Greer, P A, McCafferty, D-M

“…Background and aims: Fer kinase is activated by a number of growth factors and cytokines, and phosphorylates cortactin during cell shape change induced…”
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Amplified Ras-MAPK signal states correlate with accelerated EGFR internalization, cytostasis and delayed HER2 tumor onset in Fer-deficient model systems by Sangrar, W, Shi, C, Mullins, G, LeBrun, D, Ingalls, B, Greer, P A

“…The non-receptor tyrosine kinase Fer belongs to a distinct subfamily of F-BAR domain containing kinases implicated in vesicular trafficking and signaling…”
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Mice Devoid of Fer Protein-Tyrosine Kinase Activity Are Viable and Fertile but Display Reduced Cortactin Phosphorylation by Craig, Andrew W. B., Zirngibl, Ralph, Williams, Karen, Cole, Lesley-Ann, Greer, Peter A.

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Calpain‐activated mTORC2/Akt pathway mediates airway smooth muscle remodelling in asthma by Rao, S.‐S., Mu, Q., Zeng, Y., Cai, P.‐C., Liu, F., Yang, J., Xia, Y., Zhang, Q., Song, L.‐J., Zhou, L.‐L., Li, F.‐Z., Lin, Y.‐X., Fang, J., Greer, P. A., Shi, H.‐Z., Ma, W.‐L., Su, Y., Ye, H.

“…Summary Background Allergic asthma is characterized by inflammation and airway remodelling. Airway remodelling with excessive deposition of extracellular…”
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FES-Cre targets phosphatidylinositol glycan class A (PIGA) inactivation to hematopoietic stem cells in the bone marrow by Keller, P, Payne, J L, Tremml, G, Greer, P A, Gaboli, M, Pandolfi, P P, Bessler, M

“…A somatic mutation in the X-linked phosphatidylinositol glycan class A (PIGA) gene causes the loss of glycosyl phosphatidylinositol (GPI)-linked proteins on…”
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Fps/Fes and Fer non‐receptor protein‐tyrosine kinases regulate collagen‐ and ADP‐induced platelet aggregation by Senis, Y. A., Sangrar, W., Zirngibl, R. A., Craig, A. W. B., Lee, D. H., Greer, P. A.

“…Fps/Fes and Fer proto‐oncoproteins are structurally related non‐receptor protein‐tyrosine kinases implicated in signaling downstream from cytokines, growth…”
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Vascular defects in gain‐of‐function fps/fes transgenic mice correlate with PDGF‐ and VEGF‐induced activation of mutant Fps/Fes kinase in endothelial cells by Sangrar, W., Mewburn, J. D., Vincent, S. G., Fisher, J. T., Greer, P. A.

“…Background: Fps/Fes is a cytoplasmic tyrosine kinase that is abundantly expressed in the myeloid, endothelial, epithelial, neuronal and platelet lineages…”
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Hemostatic and hematological abnormalities in gain‐of‐function fps/fes transgenic mice are associated with the angiogenic phenotype by Sangrar, W., Senis, Y., Samis, J. A., Gao, Y., Richardson, M., Lee, D. H., Greer, P. A.

“…The Fps/Fes tyrosine kinase has been implicated in the regulation of hematopoiesis and inflammation. Mice expressing an activated variant of Fps/Fes (MFps)…”
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Disruption of the Murine Calpain Small Subunit Gene, Capn4: Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division by Arthur, J. Simon C., Elce, John S., Hegadorn, Carol, Williams, Karen, Greer, Peter A.

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Reduced Cell Migration and Disruption of the Actin Cytoskeleton in Calpain-deficient Embryonic Fibroblasts by Dourdin, Nathalie, Bhatt, Amit K., Dutt, Previn, Greer, Peter A., Arthur, J. Simon C., Elce, John S., Huttenlocher, Anna

“…The physiological functions and substrates of the calcium-dependent protease calpain remain only partly understood. The μ- and m-calpains consist of a μ- or…”
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Degenerate PCR-based cloning method for Eph receptors and analysis of their expression in the developing murine central nervous system and vasculature by Bovenkamp, D E, Greer, P A

“…Eph receptors and their membrane-associated ephrin ligands regulate cell-cell interactions during development. The biochemical and biologic functions of this…”
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The human c-fps/fes gene product expressed ectopically in rat fibroblasts is nontransforming and has restrained protein-tyrosine kinase activity by GREER, P. A, MECKLING-HANSEN, K, PAWSON, T

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Calpains Mediate p53 Activation and Neuronal Death Evoked by DNA Damage by Sedarous, Mary, Keramaris, Elizabeth, O'Hare, Michael, Melloni, Edon, Slack, Ruth S., Elce, John S., Greer, Peter A., Park, David S.

“…DNA damage is an initiator of neuronal death implicated in neuropathological conditions such as stroke. Previous evidence has shown that apoptotic death of…”
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Treatment with 5-aminolevulinic acid and photoactivating light causes destruction of preimplantation mouse embryos by Yang, J Z, Greer, P A, van Vugt, D A, Reid, R L

“…To evaluate the direct effect of photodynamic treatment with 5-aminolevulinic acid (ALA) on preimplantation mouse embryos in an in vitro setting…”
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Fer Kinase Is Required for Sustained p38 Kinase Activation and Maximal Chemotaxis of Activated Mast Cells by Craig, Andrew W. B., Greer, Peter A.

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Enhanced Endotoxin Sensitivity in Fps/Fes-Null Mice with Minimal Defects in Hematopoietic Homeostasis by Zirngibl, Ralph A., Senis, Yotis, Greer, Peter A.

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