Search Results - "Greer, John J"

Current concepts on the pathogenesis and etiology of congenital diaphragmatic hernia by Greer, John J

“…Highlights • CDH is characterized by the incomplete formation of the diaphragm in utero. • There are teratogenic, Vit A-deficient, and genetically engineered…”
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G-protein–gated Inwardly Rectifying Potassium Channels Modulate Respiratory Depression by Opioids by Montandon, Gaspard, Ren, Jun, Victoria, Nicole C, Liu, Hattie, Wickman, Kevin, Greer, John J, Horner, Richard L

“…BACKGROUND:Drugs acting on μ-opioid receptors (MORs) are widely used as analgesics but present side effects including life-threatening respiratory depression…”
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The rhythmic, transverse medullary slice preparation in respiratory neurobiology: Contributions and caveats by Funk, Gregory D, Greer, John J

“…Highlights ► We describe the rhythmic medullary slice preparation and variations of it. ► We review key contributions that have resulted from the analysis of…”
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State-dependent modulation of breathing in urethane-anesthetized rats by Pagliardini, Silvia, Greer, John J, Funk, Gregory D, Dickson, Clayton T

“…Respiratory activity is most fragile during sleep, in particular during paradoxical [or rapid eye movement (REM)] sleep and sleep state transitions. Rats are…”
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Ampakine CX717 Protects against Fentanyl-induced Respiratory Depression and Lethal Apnea in Rats by JUN REN, XIUQING DING, FUNK, Gregory D, GREER, John J

“…The use of fentanyl as a potent analgesic is contradicted by marked respiratory depression among a subpopulation of patients. The commonly used approach of…”
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Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities by Samaco, Rodney C, Mandel-Brehm, Caleigh, Chao, Hsiao-Tuan, Ward, Christopher S, Fyffe-Maricich, Sharyl L, Ren, Jun, Hyland, Keith, Thaller, Christina, Maricich, Stephen M, Humphreys, Peter, Greer, John J, Percy, Alan, Glaze, Daniel G, Zoghbi, Huda Y, Neul, Jeffrey L

“…Rett syndrome (RTT) is characterized by specific motor, cognitive, and behavioral deficits. Because several of these abnormalities occur in other disease…”
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Math1 Is Essential for the Development of Hindbrain Neurons Critical for Perinatal Breathing by Rose, Matthew F., Ren, Jun, Ahmad, Kaashif A., Chao, Hsiao-Tuan, Klisch, Tiemo J., Flora, Adriano, Greer, John J., Zoghbi, Huda Y.

“…Mice lacking the proneural transcription factor Math1 ( Atoh1) lack multiple neurons of the proprioceptive and arousal systems and die shortly after birth from…”
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Anxiety-related mechanisms of respiratory dysfunction in a mouse model of Rett syndrome by Ren, Jun, Ding, Xiuqing, Funk, Gregory D, Greer, John J

“…Rett syndrome (RTT) is a severe neurological disorder that is associated with mutations in the methyl-CpG binding protein 2 (MECP2) gene. RTT patients suffer…”
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Early development of the primordial mammalian diaphragm and cellular mechanisms of nitrofen-induced congenital diaphragmatic hernia by Clugston, Robin D., Zhang, Wei, Greer, John J.

“…Congenital diaphragmatic hernia (CDH) is a frequently occurring cause of neonatal respiratory distress and is associated with high mortality and long‐term…”
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Modulation of Respiratory Rhythmogenesis by Chloride-Mediated Conductances during the Perinatal Period by Ren, Jun, Greer, John J

“…Respiratory rhythmogenesis is modulated by chloride-mediated conductances via GABAA and glycine receptors. In this study, we determine the actions of…”
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Opiate-induced suppression of rat hypoglossal motoneuron activity and its reversal by ampakine therapy by Lorier, Amanda R, Funk, Gregory D, Greer, John J

“…Hypoglossal (XII) motoneurons innervate tongue muscles and are vital for maintaining upper-airway patency during inspiration. Depression of XII nerve activity…”
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Cardiorespiratory pathogenesis of sickle cell disease in a mouse model by Ren, Jun, Ding, Xiuqing, Trudel, Marie, Greer, John J., MacLean, Joanna E.

“…The nature and development of cardiorespiratory impairments associated with sickle cell disease are poorly understood. Given that the mechanisms of these…”
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Diaphragm development and congenital diaphragmatic hernia by Clugston, Robin D, Greer, John J., PhD

“…Advances in the understanding of normal diaphragm embryogenesis have provided the necessary foundation for novel insights into the pathogenesis of congenital…”
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Gene expression in the developing diaphragm: significance for congenital diaphragmatic hernia by Clugston, Robin D, Zhang, Wei, Greer, John J

“…Congenital diaphragmatic hernia (CDH) is a frequently occurring birth defect and a source of potentially fatal neonatal respiratory distress. Recently, through…”
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Mechanisms of action of the congenital diaphragmatic hernia-inducing teratogen nitrofen by Noble, B Rhiannon, Babiuk, Randal P, Clugston, Robin D, Underhill, T Michael, Sun, Hui, Kawaguchi, Riki, Walfish, Paul G, Blomhoff, Rune, Gundersen, Thomas E, Greer, John J

“…Congenital diaphragmatic hernia (CDH) is a developmental anomaly that results in significant mortality and morbidity. The underlying etiology is poorly…”
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Anatomical and functional development of the pre-Botzinger complex in prenatal rodents by Thoby-Brisson, Muriel, Greer, John J

“…1 Laboratoire de Neurobiologie Génétique et Intégrative. Institut Alfred Fessard, CNRS, Gif sur Yvette, France; and 2 Department of Physiology, Centre for…”
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Teratogen-Induced, Dietary and Genetic Models of Congenital Diaphragmatic Hernia Share a Common Mechanism of Pathogenesis by Clugston, Robin D., Klattig, Jürgen, Englert, Chistoph, Clagett-Dame, Margaret, Martinovic, Jelena, Benachi, Alexandra, Greer, John J.

“…Congenital diaphragmatic hernia (CDH) is a frequently occurring, major congenital abnormality that has high mortality and significant morbidity in survivors…”
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Tripartite Purinergic Modulation of Central Respiratory Networks during Perinatal Development: The Influence of ATP, Ectonucleotidases, and ATP Metabolites by Huxtable, Adrianne G, Zwicker, Jennifer D, Poon, Betty Y, Pagliardini, Silvia, Vrouwe, Sebastian Q, Greer, John J, Funk, Gregory D

“…ATP released during hypoxia from the ventrolateral medulla activates purinergic receptors (P2Rs) to attenuate the secondary hypoxic depression of breathing by…”
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Novel Therapies for the Treatment of Central Sleep Apnea by Javaheri, Shahrokh, MD, Germany, Robin, MD, Greer, John J., PhD

“…Neurophysiologically, central apnea is due to a temporary cessation of respiratory rhythmogenesis in medullary respiratory networks. Central apneas occur in…”
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Ontogeny of the Pre-Botzinger Complex in Perinatal Rats by Pagliardini, Silvia, Ren, Jun, Greer, John J

“…The aim of this study was to provide a systematic examination of the ontogenesis of the mammalian respiratory rhythm generating center, the pre-Bötzinger…”
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