Search Results - "Greenwood, M T"

Genetic architecture: the shape of the genetic contribution to human traits and disease by Timpson, Nicholas J., Greenwood, Celia M. T., Soranzo, Nicole, Lawson, Daniel J., Richards, J. Brent

“…Key Points The genetic architecture of common diseases is central to the scientific and clinical goals of human genetics because it directly impacts biology,…”
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Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases by Chen, Yiheng, Lu, Tianyuan, Pettersson-Kymmer, Ulrika, Stewart, Isobel D., Butler-Laporte, Guillaume, Nakanishi, Tomoko, Cerani, Agustin, Liang, Kevin Y. H., Yoshiji, Satoshi, Willett, Julian Daniel Sunday, Su, Chen-Yang, Raina, Parminder, Greenwood, Celia M. T., Farjoun, Yossi, Forgetta, Vincenzo, Langenberg, Claudia, Zhou, Sirui, Ohlsson, Claes, Richards, J. Brent

“…Metabolic processes can influence disease risk and provide therapeutic targets. By conducting genome-wide association studies of 1,091 blood metabolites and…”
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Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study by Mokry, Lauren E, Ross, Stephanie, Ahmad, Omar S, Forgetta, Vincenzo, Smith, George Davey, Goltzman, David, Leong, Aaron, Greenwood, Celia M T, Thanassoulis, George, Richards, J Brent

“…Observational studies have demonstrated an association between decreased vitamin D level and risk of multiple sclerosis (MS); however, it remains unclear…”
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Development of a polygenic risk score to improve screening for fracture risk: A genetic risk prediction study by Forgetta, Vincenzo, Keller-Baruch, Julyan, Forest, Marie, Durand, Audrey, Bhatnagar, Sahir, Kemp, John P, Nethander, Maria, Evans, Daniel, Morris, John A, Kiel, Douglas P, Rivadeneira, Fernando, Johansson, Helena, Harvey, Nicholas C, Mellström, Dan, Karlsson, Magnus, Cooper, Cyrus, Evans, David M, Clarke, Robert, Kanis, John A, Orwoll, Eric, McCloskey, Eugene V, Ohlsson, Claes, Pineau, Joelle, Leslie, William D, Greenwood, Celia M T, Richards, J Brent

“…Since screening programs identify only a small proportion of the population as eligible for an intervention, genomic prediction of heritable risk factors could…”
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Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors by Rivera, Barbara, Gayden, Tenzin, Carrot-Zhang, Jian, Nadaf, Javad, Boshari, Talia, Faury, Damien, Zeinieh, Michele, Blanc, Romeo, Burk, David L., Fahiminiya, Somayyeh, Bareke, Eric, Schüller, Ulrich, Monoranu, Camelia M., Sträter, Ronald, Kerl, Kornelius, Niederstadt, Thomas, Kurlemann, Gerhard, Ellezam, Benjamin, Michalak, Zuzanna, Thom, Maria, Lockhart, Paul J., Leventer, Richard J., Ohm, Milou, MacGregor, Duncan, Jones, David, Karamchandani, Jason, Greenwood, Celia M. T., Berghuis, Albert M., Bens, Susanne, Siebert, Reiner, Zakrzewska, Magdalena, Liberski, Pawel P., Zakrzewski, Krzysztof, Sisodiya, Sanjay M., Paulus, Werner, Albrecht, Steffen, Hasselblatt, Martin, Jabado, Nada, Foulkes, William D., Majewski, Jacek

“…Dysembryoplastic neuroepithelial tumor (DNET) is a benign brain tumor associated with intractable drug-resistant epilepsy. In order to identify underlying…”
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Estimating Genome-Wide Significance for Whole-Genome Sequencing Studies by Xu, ChangJiang, Tachmazidou, Ioanna, Walter, Klaudia, Ciampi, Antonio, Zeggini, Eleftheria, Greenwood, Celia M. T.

“…ABSTRACT Although a standard genome‐wide significance level has been accepted for the testing of association between common genetic variants and disease, the…”
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Reproductive decision making after the diagnosis of multiple sclerosis (MS) by Alwan, S, Yee, IM, Dybalski, M, Guimond, C, Dwosh, E, Greenwood, TM, Butler, R, Sadovnick, AD

“…Objective: This study aimed to determine reproductive practices and attitudes of North Americans diagnosed with multiple sclerosis (MS) and the reasons for…”
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The empirical power of rare variant association methods: results from sanger sequencing in 1,998 individuals by Ladouceur, Martin, Dastani, Zari, Aulchenko, Yurii S, Greenwood, Celia M T, Richards, J Brent

“…The role of rare genetic variation in the etiology of complex disease remains unclear. However, the development of next-generation sequencing technologies…”
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Polygenic risk for coronary heart disease acts through atherosclerosis in type 2 diabetes by Lu, Tianyuan, Forgetta, Vincenzo, Yu, Oriana H Y, Mokry, Lauren, Gregory, Madeline, Thanassoulis, George, Greenwood, Celia M T, Richards, J Brent

“…Type 2 diabetes increases the risk of coronary heart disease (CHD), yet the mechanisms involved remain poorly described. Polygenic risk scores (PRS) provide an…”
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Identifying Differential Methylation in Cancer Epigenetics via a Bayesian Functional Regression Model by Shokoohi, Farhad, Stephens, David A, Greenwood, Celia M T

“…DNA methylation plays an essential role in regulating gene activity, modulating disease risk, and determining treatment response. We can obtain insight into…”
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Improved prediction of fracture risk leveraging a genome-wide polygenic risk score by Lu, Tianyuan, Forgetta, Vincenzo, Keller-Baruch, Julyan, Nethander, Maria, Bennett, Derrick, Forest, Marie, Bhatnagar, Sahir, Walters, Robin G, Lin, Kuang, Chen, Zhengming, Li, Liming, Karlsson, Magnus, Mellström, Dan, Orwoll, Eric, McCloskey, Eugene V, Kanis, John A, Leslie, William D, Clarke, Robert J, Ohlsson, Claes, Greenwood, Celia M T, Richards, J Brent

“…Accurately quantifying the risk of osteoporotic fracture is important for directing appropriate clinical interventions. While skeletal measures such as heel…”
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Functional normalization of 450k methylation array data improves replication in large cancer studies by Fortin, Jean-Philippe, Labbe, Aurélie, Lemire, Mathieu, Zanke, Brent W, Hudson, Thomas J, Fertig, Elana J, Greenwood, Celia Mt, Hansen, Kasper D

“…We propose an extension to quantile normalization that removes unwanted technical variation using control probes. We adapt our algorithm, functional…”
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An evaluation of methods correcting for cell-type heterogeneity in DNA methylation studies by McGregor, Kevin, Bernatsky, Sasha, Colmegna, Ines, Hudson, Marie, Pastinen, Tomi, Labbe, Aurélie, Greenwood, Celia M T

“…Many different methods exist to adjust for variability in cell-type mixture proportions when analyzing DNA methylation studies. Here we present the result of…”
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PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores by Chen, Lawrence M, Yao, Nelson, Garg, Elika, Zhu, Yuecai, Nguyen, Thao T T, Pokhvisneva, Irina, Hari Dass, Shantala A, Unternaehrer, Eva, Gaudreau, Hélène, Forest, Marie, McEwen, Lisa M, MacIsaac, Julia L, Kobor, Michael S, Greenwood, Celia M T, Silveira, Patricia P, Meaney, Michael J, O'Donnell, Kieran J

“…Polygenic risk scores (PRS) describe the genomic contribution to complex phenotypes and consistently account for a larger proportion of variance in outcome…”
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MDiNE: a model to estimate differential co-occurrence networks in microbiome studies by McGregor, Kevin, Labbe, Aurélie, Greenwood, Celia M T

“…Abstract Motivation The human microbiota is the collection of microorganisms colonizing the human body, and plays an integral part in human health. A growing…”
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Chromosome-breakage genomic instability and chromothripsis in breast cancer by Przybytkowski, Ewa, Lenkiewicz, Elizabeth, Barrett, Michael T, Klein, Kathleen, Nabavi, Sheida, Greenwood, Celia M T, Basik, Mark

“…Chromosomal breakage followed by faulty DNA repair leads to gene amplifications and deletions in cancers. However, the mere assessment of the extent of genomic…”
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A region-based gene association study combined with a leave-one-out sensitivity analysis identifies SMG1 as a pancreatic cancer susceptibility gene by Wong, Cavin, Chen, Fei, Alirezaie, Najmeh, Wang, Yifan, Cuggia, Adeline, Borgida, Ayelet, Holter, Spring, Lenko, Tatiana, Domecq, Celine, Petersen, Gloria M, Syngal, Sapna, Brand, Randall, Rustgi, Anil K, Cote, Michele L, Stoffel, Elena, Olson, Sara H, Roberts, Nicholas J, Akbari, Mohammad R, Majewski, Jacek, Klein, Alison P, Greenwood, Celia M T, Gallinger, Steven, Zogopoulos, George

“…Pancreatic adenocarcinoma (PC) is a lethal malignancy that is familial or associated with genetic syndromes in 10% of cases. Gene-based surveillance strategies…”
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Capturing additional genetic risk from family history for improved polygenic risk prediction by Lu, Tianyuan, Forgetta, Vincenzo, Richards, J. Brent, Greenwood, Celia M. T.

“…Family history of complex traits may reflect transmitted rare pathogenic variants, intra-familial shared exposures to environmental and lifestyle factors, as…”
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Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesis by Lu, Tianyuan, Klein, Kathleen Oros, Colmegna, Inés, Lora, Maximilien, Greenwood, Celia M T, Hudson, Marie

“…Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease whose pathogenesis remains incompletely understood. Increasing evidence suggests that…”
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A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene by Fierheller, Caitlin T, Guitton-Sert, Laure, Alenezi, Wejdan M, Revil, Timothée, Oros, Kathleen K, Gao, Yuandi, Bedard, Karine, Arcand, Suzanna L, Serruya, Corinne, Behl, Supriya, Meunier, Liliane, Fleury, Hubert, Fewings, Eleanor, Subramanian, Deepak N, Nadaf, Javad, Bruce, Jeffrey P, Bell, Rachel, Provencher, Diane, Foulkes, William D, El Haffaf, Zaki, Mes-Masson, Anne-Marie, Majewski, Jacek, Pugh, Trevor J, Tischkowitz, Marc, James, Paul A, Campbell, Ian G, Greenwood, Celia M T, Ragoussis, Jiannis, Masson, Jean-Yves, Tonin, Patricia N

“…Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the BRCA1 and BRCA2 OC-predisposing genes, which function in homologous…”
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