Search Results - "Greenwald, Robert A."

The road forward: The scientific basis for tetracycline treatment of arthritic disorders by Greenwald, Robert A.

“…The potential role of a collagenase inhibitor for treatment of arthritis was recognized almost immediately after the discovery of vertebrate collagenase. Yet…”
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Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis by Rosenstein, Elliot D, Greenwald, Robert A, Kushner, Laura J, Weissmann, Gerald

“…Rheumatoid arthritis (RA) and adult periodontitis share common pathogenetic mechanisms and immunologic and pathological findings. One oral pathogen strongly…”
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Inhibition of Matrix Metalloproteinase‐Mediated Periodontal Bone Loss in Rats: A Comparison of 6 Chemically Modified Tetracyclines by Ramamurthy, Nungavarum S., Rifkin, Barry R., Greenwald, Robert A., Xu, Jing‐wen, Liu, Yu, Turner, Gloza, Golub, Lorne M., Vernillo, Anthony T.

“…Background: Chemically modified tetracyclines (CMTs), devoid of antimicrobial activity, inhibit pathologically elevated collagenase activity both in vivo and…”
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Clinical applications of non-antibacterial tetracyclines. Part II by Golub, Lorne M., Greenwald, Robert A.

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Potential of tetracyclines to modify cartilage breakdown in osteoarthritis by Ryan, M E, Greenwald, R A, Golub, L M

“…For several decades, it has been recognized that an imbalance between activated matrix metalloproteinases, generated locally by both infiltrating and resident…”
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Porphyromonas gingivalis , periodontitis and rheumatoid arthritis by Rosenstein, Elliot D, Weissmann, Gerald, Greenwald, Robert A

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Experimental Arthritis in Rats Induces Biomarkers of Periodontitis Which Are Ameliorated by Gene Therapy With Tissue Inhibitor of Matrix Metalloproteinases by Ramamurthy, Nungavaram S., Greenwald, Robert A., Celiker, Mohamed Y., Shi, Eric Y.

“…Background: Periodontal disease (PD) and rheumatoid arthritis (RA) share many common pathophysiologic features, but a clinical relationship between the two…”
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Oxygen radicals, inflammation, and arthritis: pathophysiological considerations and implications for treatment by Greenwald, R A

“…A vast amount of circumstantial evidence implicates oxygen-derived free radicals, especially superoxide and hydroxyl radical (and to lesser extent, hydrogen…”
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The ACRONYM Project by Greenwald, Robert A

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Inhibition of alveolar bone loss by matrix metalloproteinase inhibitors in experimental periodontal disease by RAMAMURTHY, Nungavaram S, XU, Jing-Wen, BIRD, John, BAXTER, Andrew, BHOGAL, Ranjev, WILLS, Ruth, WATSON, Bob, OWEN, David, WOLFF, Mark, GREENWALD, Robert A

“…Periodontal disease is characterized by excessive host collagenase resulting in loss of gingival and periodontal ligament collagen and adjacent alveolar bone…”
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Biologic properties of non-antibiotic, chemically modified tetracyclines (CMTs): a structured, annotated bibliography by Greenwald, R, Golub, L

“…The first paper reporting on a potentially important medical property of a non-antimicrobial tetracycline appeared in 1987. Since then, a literature of over 75…”
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Potential applications of matrix metalloproteinase inhibitors in geriatric practice by Marder, Galina, Greenwald, Robert A

“…Matrix metalloproteinases are a family of enzymes that degrade different components of extracellular matrix. They play an important role in normal physiologic…”
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Inhibition of enzymatic activity of phospholipases A2 by minocycline and doxycycline by Pruzanski, W, Greenwald, R A, Street, I P, Laliberte, F, Stefanski, E, Vadas, P

“…Extracellular phospholipases A2 play an important role in articular and extra-articular inflammatory processes. Secretory non-pancreatic phospholipase A2…”
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Preface by Greenwald, Robert A.

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Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs by Golub, L M, Ramamurthy, N S, McNamara, T F, Greenwald, R A, Rifkin, B R

“…Tetracyclines have long been considered useful adjuncts in peridontal therapy based on their antimicrobial efficacy against putative periodontopathogens…”
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Marginal efficacy of glucosamine: Comment on the article by VLAD et al and the editorial by Reginster by Greenwald, Robert A.

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Arthritis and Allied Conditions: A Textbook of Rheumatology by Greenwald, Robert A

“…The 11th edition of this classic compendium of rheumatologic knowledge should be reviewed in the context of its intended audience (the specialist's reference…”
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Synoviocytes are more sensitive than cartilage to the effects of minocycline and doxycycline on IL-1α and MMP-13-induced catabolic gene responses by Fortier, Lisa A., Motta, Tatiana, Greenwald, Robert A., Divers, Thomas J., Mayr, Karen G.

“…The objective of this study was to determine the primary articular tissue target of doxycycline and minocycline. Synoviocytes—cartilage cocultures (n = 4) were…”
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Synoviocytes are more sensitive than cartilage to the effects of minocycline and doxycycline on IL-1α and MMP-13-induced catabolic gene responses: TETRACYCLINE COMPOUNDS, SYNOVIOCYTES AND CARTILAGE by Fortier, Lisa A., Motta, Tatiana, Greenwald, Robert A., Divers, Thomas J., Mayr, Karen G.

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Thirty-six Years in the Clinic without an MMP Inhibitor: What Hath Collagenase Wrought? by GREENWALD, ROBERT A.

“…Vertebrate collagenase was discovered in 1962, and within a few short years, several inhibitors had been identified. At one time or another, virtually every…”
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