Search Results - "Greenstein, L."

A Multipurpose Toolkit to Enable Advanced Genome Engineering in Plants by Čermák, Tomáš, Curtin, Shaun J., Gil-Humanes, Javier, Čegan, Radim, Kono, Thomas J.Y., Konečná, Eva, Belanto, Joseph J., Starker, Colby G., Mathre, Jade W., Greenstein, Rebecca L., Voytas, Daniel F.

“…We report a comprehensive toolkit that enables targeted, specific modification of monocot and dicot genomes using a variety of genome engineering approaches…”
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Estimating ectopic beat probability with simplified statistical models that account for experimental uncertainty by Jin, Qingchu, Greenstein, Joseph L, Winslow, Raimond L

“…Ectopic beats (EBs) are cellular arrhythmias that can trigger lethal arrhythmias. Simulations using biophysically-detailed cardiac myocyte models can reveal…”
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Burden of comorbidities in South Africans with systemic lupus erythematosus by Greenstein, L., Makan, K., Tikly, Mohammed

“…Introduction To investigate the prevalence and spectrum of comorbidities in South Africans with systemic lupus erythematosus (SLE). Patients and methods A…”
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A generic model for optimizing single-hop transmission policy of replenishable sensors by Jing Lei, Yates, R., Greenstein, L.

“…Energy harvesting from the working environment has received increasing attention in the research of wireless sensor networks. Recent developments in this area…”
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A data-driven model for early prediction of need for invasive mechanical ventilation in pediatric intensive care unit patients by Bose, Sanjukta N, Defante, Andrew, Greenstein, Joseph L, Haddad, Gabriel G, Ryu, Julie, Winslow, Raimond L

“…Acute respiratory failure is a life-threatening clinical outcome in critically ill pediatric patients. In severe cases, patients can require mechanical…”
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A Computational Model of Reactive Oxygen Species and Redox Balance in Cardiac Mitochondria by Gauthier, Laura D., Greenstein, Joseph L., Cortassa, Sonia, O’Rourke, Brian, Winslow, Raimond L.

“…Elevated levels of reactive oxygen species (ROS) play a critical role in cardiac myocyte signaling in both healthy and diseased cells. Mitochondria represent…”
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Mechanistic Investigation of the Arrhythmogenic Role of Oxidized CaMKII in the Heart by Foteinou, Panagiota T., Greenstein, Joseph L., Winslow, Raimond L.

“…Oxidative stress and calcium (Ca2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) both play important roles in the pathogenesis of cardiac disease…”
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Roles of phosphodiesterases in the regulation of the cardiac cyclic nucleotide cross-talk signaling network by Zhao, Claire Y, Greenstein, Joseph L, Winslow, Raimond L

“…Abstract The balanced signaling between the two cyclic nucleotides (cNs) cAMP and cGMP plays a critical role in regulating cardiac contractility. Their…”
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Decode-and-Forward Cooperative Diversity with Power Allocation in Wireless Networks by Luo, J., Blum, R.S., Cimini, L.J., Greenstein, L.J., Haimovich, A.M.

“…We study power allocation for the decode-and-forward cooperative diversity protocol in a wireless network under the assumption that only mean channel gains are…”
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Spectral clustering of risk score trajectories stratifies sepsis patients by clinical outcome and interventions received by Liu, Ran, Greenstein, Joseph L, Fackler, James C, Bembea, Melania M, Winslow, Raimond L

“…Sepsis is not a monolithic disease, but a loose collection of symptoms with diverse outcomes. Thus, stratification and subtyping of sepsis patients is of great…”
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Using the physical layer for wireless authentication in time-variant channels by Liang Xiao, Greenstein, L., Mandayam, N., Trappe, W.

“…The wireless medium contains domain-specific information that can be used to complement and enhance traditional security mechanisms. In this paper we propose…”
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Superresolution Modeling of Calcium Release in the Heart by Walker, Mark A., Williams, George S.B., Kohl, Tobias, Lehnart, Stephan E., Jafri, M. Saleet, Greenstein, Joseph L., Lederer, W.J., Winslow, Raimond L.

“…Stable calcium-induced calcium release (CICR) is critical for maintaining normal cellular contraction during cardiac excitation-contraction coupling. The…”
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Electrotonic Coupling between Human Atrial Myocytes and Fibroblasts Alters Myocyte Excitability and Repolarization by Maleckar, Mary M., Greenstein, Joseph L., Giles, Wayne R., Trayanova, Natalia A.

“…Atrial fibrosis has been implicated in the development and maintenance of atrial arrhythmias, and is characterized by expansion of the extracellular matrix and…”
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SWIFT: A deep learning approach to prediction of hypoxemic events in critically-Ill patients using SpO2 waveform prediction by Annapragada, Akshaya V, Greenstein, Joseph L, Bose, Sanjukta N, Winters, Bradford D, Sarma, Sridevi V, Winslow, Raimond L

“…Hypoxemia is a significant driver of mortality and poor clinical outcomes in conditions such as brain injury and cardiac arrest in critically ill patients,…”
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A case of hyponatraemia secondary to vitamin D deficiency by Greenstein, LS, Daya, R, Jacob, D, Bayat, Z

“…Hyponatraemia and Vitamin D deficiency are common conditions in older adults. Both conditions cause bone fragility and gait abnormalities, which are risk…”
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An Integrated Mitochondrial ROS Production and Scavenging Model: Implications for Heart Failure by Gauthier, Laura D., Greenstein, Joseph L., O’Rourke, Brian, Winslow, Raimond L.

“…It has been observed experimentally that cells from failing hearts exhibit elevated levels of reactive oxygen species (ROS) upon increases in energetic…”
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K+ current changes account for the rate dependence of the action potential in the human atrial myocyte by Maleckar, Mary M, Greenstein, Joseph L, Giles, Wayne R, Trayanova, Natalia A

“…Ongoing investigation of the electrophysiology and pathophysiology of the human atria requires an accurate representation of the membrane dynamics of the human…”
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Factors associated with resistance to SARS-CoV-2 infection discovered using large-scale medical record data and machine learning by Yang, Kai-Wen K, Paris, Chloé F, Gorman, Kevin T, Rattsev, Ilia, Yoo, Rebecca H, Chen, Yijia, Desman, Jacob M, Wei, Tony Y, Greenstein, Joseph L, Taylor, Casey Overby, Ray, Stuart C

“…There have been over 621 million cases of COVID-19 worldwide with over 6.5 million deaths. Despite the high secondary attack rate of COVID-19 in shared…”
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Mechanisms of the cyclic nucleotide cross-talk signaling network in cardiac L-type calcium channel regulation by Zhao, Claire Y, Greenstein, Joseph L, Winslow, Raimond L

“…Abstract Regulation of L-type Calcium (Ca2+ ) Channel (LCC) gating is critical to shaping the cardiac action potential (AP) and triggering the initiation of…”
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Mechanisms of Excitation-Contraction Coupling in an Integrative Model of the Cardiac Ventricular Myocyte by Greenstein, Joseph L., Hinch, Robert, Winslow, Raimond L.

“…It is now well established that characteristic properties of excitation-contraction (EC) coupling in cardiac myocytes, such as high gain and graded Ca 2+…”
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