Endotoxic activity in periapical lesions

Thirty tissue samples were examined histologically and classified as being inflamed (apical granulomas) or noninflamed (scars or noninflamed cysts). The samples were then homogenized in pyrogen-free water and treated to remove interfering substances. The presence of endotoxin was then determined by...

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Bibliographic Details
Published in:	Oral surgery, oral medicine, oral pathology Vol. 53; no. 1; p. 82
Main Authors:	Schonfeld, S E, Greening, A B, Glick, D H, Frank, A L, Simon, J H, Herles, S M
Format:	Journal Article
Language:	English
Published:	United States 01-01-1982
Subjects:	Endotoxins - adverse effects Endotoxins - metabolism Humans Limulus Test Periapical Granuloma - etiology Periapical Granuloma - metabolism Periapical Granuloma - pathology
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Summary:	Thirty tissue samples were examined histologically and classified as being inflamed (apical granulomas) or noninflamed (scars or noninflamed cysts). The samples were then homogenized in pyrogen-free water and treated to remove interfering substances. The presence of endotoxin was then determined by means of the limulus assay; 75 percent of the inflamed tissues were positive for endotoxin, while only 20 percent of the noninflamed tissues contained endotoxin. The presence of endotoxin was thus highly correlated (p = 0.015) with the presence of inflammation in these tissues.
ISSN:	0030-4220
DOI:	10.1016/0030-4220(82)90491-1