Search Results - "Greengard, Paul"

Cell type–specific mRNA purification by translating ribosome affinity purification (TRAP) by Heiman, Myriam, Kulicke, Ruth, Fenster, Robert J, Greengard, Paul, Heintz, Nathaniel

“…Translating ribosome affinity purification (TRAP) combines cell type–specific transgene expression with affinity purification of translating ribosomes and can…”
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The dentate gyrus in depression by Umschweif, Gali, Greengard, Paul, Sagi, Yotam

“…Extensive preclinical research has been conducted in recent years to reveal the cell types, neuronal circuits and molecular and morphological changes…”
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Three-Dimensional Study of Alzheimer’s Disease Hallmarks Using the iDISCO Clearing Method by Liebmann, Thomas, Renier, Nicolas, Bettayeb, Karima, Greengard, Paul, Tessier-Lavigne, Marc, Flajolet, Marc

“…Amyloidosis is a major problem in over one hundred diseases, including Alzheimer’s disease (AD). Using the iDISCO visualization method involving targeted…”
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Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity by Shen, Weixing, Flajolet, Marc, Greengard, Paul, Surmeier, D. James

“…At synapses between cortical pyramidal neurons and principal striatal medium spiny neurons (MSNs), postsynaptic D1 and D2 dopamine (DA) receptors are…”
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The Neurobiology of Slow Synaptic Transmission by Greengard, Paul

“…Nerve cells communicate with each other through two mechanisms, referred to as fast and slow synaptic transmission. Fast-acting neurotransmitters, e.g.,…”
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Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy by Tian, Yuan, Chang, Jerry C., Fan, Emily Y., Flajolet, Marc, Greengard, Paul

“…The hallmarks of Alzheimer’s disease (AD) are the aggregates of amyloid-β (Aβ) peptides and tau protein. Autophagy is a major cellular pathway leading to the…”
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C99 selectively accumulates in vulnerable neurons in Alzheimer's disease by Pulina, Maria V., Hopkins, Maya, Haroutunian, Vahram, Greengard, Paul, Bustos, Victor

“…The levels and distribution of amyloid deposits in the brain does not correlate well with Alzheimer's disease (AD) progression. Therefore, it is likely that…”
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Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus by Medrihan, Lucian, Sagi, Yotam, Inde, Zintis, Krupa, Oleh, Daniels, Chelsea, Peyrache, Adrien, Greengard, Paul

“…Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used class of antidepressant drugs, but the cellular and molecular mechanisms by which…”
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Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia by Fieblinger, Tim, Graves, Steven M., Sebel, Luke E., Alcacer, Cristina, Plotkin, Joshua L., Gertler, Tracy S., Chan, C. Savio, Heiman, Myriam, Greengard, Paul, Cenci, M. Angela, Surmeier, D. James

“…The striatum is widely viewed as the fulcrum of pathophysiology in Parkinson’s disease (PD) and L-DOPA-induced dyskinesia (LID). In these disease states, the…”
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Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice by Wang, Zi-Jun, Zhong, Ping, Ma, Kaijie, Seo, Ji-Seon, Yang, Fengwei, Hu, Zihua, Zhang, Freddy, Lin, Lin, Wang, Jie, Liu, Tao, Matas, Emmanuel, Greengard, Paul, Yan, Zhen

“…Many of the genes disrupted in autism are identified as histone-modifying enzymes and chromatin remodelers, most prominently those that mediate histone…”
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Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress by Nasca, Carla, Bigio, Benedetta, Zelli, Danielle, de Angelis, Paolo, Lau, Timothy, Okamoto, Masahiro, Soya, Hideyo, Ni, Jason, Brichta, Lars, Greengard, Paul, Neve, Rachael L., Lee, Francis S., McEwen, Bruce S.

“…We demonstrate that stress differentially regulates glutamate homeostasis in the dorsal and ventral hippocampus and identify a role for the astroglial xCT in…”
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MicroRNA-128 Governs Neuronal Excitability and Motor Behavior in Mice by Tan, Chan Lek, Plotkin, Joshua L., Venø, Morten T., von Schimmelmann, Melanie, Feinberg, Philip, Mann, Silas, Handler, Annie, Kjems, Jørgen, Surmeier, D. James, O'Carroll, Dónal, Greengard, Paul, Schaefer, Anne

“…The control of motor behavior in animals and humans requires constant adaptation of neuronal networks to signals of various types and strengths. We found that…”
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A Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake by Azevedo, Estefania P., Pomeranz, Lisa, Cheng, Jia, Schneeberger, Marc, Vaughan, Roger, Stern, Sarah A., Tan, Bowen, Doerig, Katherine, Greengard, Paul, Friedman, Jeffrey M.

“…Associative learning of food cues that link location in space to food availability guides feeding behavior in mammals. However, the function of specific…”
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Serotonin receptor 4 in the hippocampus modulates mood and anxiety by Karayol, Remzi, Medrihan, Lucian, Warner-Schmidt, Jennifer L., Fait, Ben W., Rao, Meghana N., Holzner, Eva B., Greengard, Paul, Heintz, Nathaniel, Schmidt, Eric F.

“…Serotonin receptor 4 (5-HT 4 R) plays an important role in regulating mood, anxiety, and cognition, and drugs that activate this receptor have fast-acting…”
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Cerebellar neurodegeneration in the absence of microRNAs by Schaefer, Anne, O'Carroll, Dónal, Tan, Chan Lek, Hillman, Dean, Sugimori, Mutsuyuki, Llinas, Rodolfo, Greengard, Paul

“…Genome-encoded microRNAs (miRNAs) are potent regulators of gene expression. The significance of miRNAs in various biological processes has been suggested by…”
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Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease by Greengard, Paul, He, Gen, Luo, Wenjie, Li, Peng, Remmers, Christine, Netzer, William J, Hendrick, Joseph, Bettayeb, Karima, Flajolet, Marc, Gorelick, Fred, Wennogle, Lawrence P

“…Accumulation of neurotoxic amyloid- is a major hallmark of Alzheimer's disease. Formation of amyloid- is catalysed by -secretase, a protease with numerous…”
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Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans by Warner-Schmidt, Jennifer L, Vanover, Kimberly E, Chen, Emily Y, Marshall, John J, Greengard, Paul

“…Antiinflammatory drugs achieve their therapeutic actions at least in part by regulation of cytokine formation. A "cytokine hypothesis" of depression is…”
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M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia by Shen, Weixing, Plotkin, Joshua L., Francardo, Veronica, Ko, Wai Kin D., Xie, Zhong, Li, Qin, Fieblinger, Tim, Wess, Jürgen, Neubig, Richard R., Lindsley, Craig W., Conn, P. Jeffrey, Greengard, Paul, Bezard, Erwan, Cenci, M. Angela, Surmeier, D. James

“…A balanced interaction between dopaminergic and cholinergic signaling in the striatum is critical to goal-directed behavior. But how this interaction modulates…”
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p11 and its role in depression and therapeutic responses to antidepressants by Svenningsson, Per, Kim, Yong, Warner-Schmidt, Jennifer, Oh, Yong-Seok, Greengard, Paul

“…Recent studies have shown that the protein p11 (also known as S100A10) has an important role in depression-like behaviour and antidepressant actions. Greengard…”
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Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice by Wang, Hong, Warner-Schmidt, Jennifer, Varela, Santiago, Enikolopov, Grigori, Greengard, Paul, Flajolet, Marc

“…Adult neurogenesis in the hippocampus subgranular zone is associated with the etiology and treatment efficiency of depression. Factors that affect adult…”
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