Search Results - "Greengard, P"

Cellular and molecular basis for stress-induced depression by Seo, J-S, Wei, J, Qin, L, Kim, Y, Yan, Z, Greengard, P

“…Chronic stress has a crucial role in the development of psychiatric diseases, such as anxiety and depression. Dysfunction of the medial prefrontal cortex…”
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The Neurobiology of Slow Synaptic Transmission by Greengard, Paul

“…Nerve cells communicate with each other through two mechanisms, referred to as fast and slow synaptic transmission. Fast-acting neurotransmitters, e.g.,…”
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Elevation of p11 in lateral habenula mediates depression-like behavior by Seo, J-S, Zhong, P, Liu, A, Yan, Z, Greengard, P

“…The lateral habenula (LHb) is a key brain region involved in the pathophysiology of depression. It is activated by stimuli associated with negative experiences…”
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Critical Involvement of cAMP/DARPP-32 and Extracellular Signal-Regulated Protein Kinase Signaling in L-DOPA-Induced Dyskinesia by Santini, Emanuela, Valjent, Emmanuel, Usiello, Alessandro, Carta, Manolo, Borgkvist, Anders, Girault, Jean-Antoine, Herve, Denis, Greengard, Paul, Fisone, Gilberto

“…The molecular basis of L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID), one of the major hindrances in the current therapy for Parkinson's…”
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CK2 regulates 5-HT4 receptor signaling and modulates depressive-like behavior by Castello, J, LeFrancois, B, Flajolet, M, Greengard, P, Friedman, E, Rebholz, H

“…The serotonergic neurotransmitter system has been widely implicated in the pathophysiology of mood-related disorders such as anxiety and major depressive…”
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Alteration by p11 of mGluR5 localization regulates depression-like behaviors by Lee, K-W, Westin, L, Kim, J, Chang, J C, Oh, Y-S, Amreen, B, Gresack, J, Flajolet, M, Kim, D, Aperia, A, Kim, Y, Greengard, P

“…Mood disorders and antidepressant therapy involve alterations of monoaminergic and glutamatergic transmission. The protein S100A10 (p11) was identified as a…”
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Correction: Elevation of p11 in lateral habenula mediates depression-like behavior by Seo, J-S., Zhong, P., Liu, A., Yan, Z., Greengard, P.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor by Brivanlou, Ali H, Sato, Noboru, Meijer, Laurent, Skaltsounis, Leandros, Greengard, Paul

“…Human and mouse embryonic stem cells (HESCs and MESCs, respectively) self-renew indefinitely while maintaining the ability to generate all three germ-layer…”
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Correction: Cellular and molecular basis for stress-induced depression by Seo, J.-S., Wei, J., Qin, L., Kim, Y., Yan, Z., Greengard, P.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia by Devor, A, Andreassen, O A, Wang, Y, Mäki-Marttunen, T, Smeland, O B, Fan, C-C, Schork, A J, Holland, D, Thompson, W K, Witoelar, A, Chen, C-H, Desikan, R S, McEvoy, L K, Djurovic, S, Greengard, P, Svenningsson, P, Einevoll, G T, Dale, A M

“…The most recent genome-wide association studies (GWAS) of schizophrenia (SCZ) identified hundreds of risk variants potentially implicated in the disease…”
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Three-Dimensional Architecture of Presynaptic Terminal Cytomatrix by Siksou, Lea, Rostaing, Philippe, Lechaire, Jean-Pierre, Boudier, Thomas, Ohtsuka, Toshihisa, Fejtova, Anna, Kao, Hung-Teh, Greengard, Paul, Gundelfinger, Eckart D, Triller, Antoine, Marty, Serge

“…Presynaptic terminals are specialized for mediating rapid fusion of synaptic vesicles (SVs) after calcium influx. The regulated trafficking of SVs likely…”
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Regulation of a Protein Phosphatase Cascade Allows Convergent Dopamine and Glutamate Signals to Activate ERK in the Striatum by Valjent, Emmanuel, Pascoli, Vincent, Svenningsson, Per, Paul, Surojit, Enslen, Hervé, Corvol, Jean-Christophe, Stipanovich, Alexandre, Caboche, Jocelyne, Lombroso, Paul J., Nairn, Angus C., Greengard, Paul, Hervé, Denis, Girault, Jean-Antoine

“…Many drugs of abuse exert their addictive effects by increasing extracellular dopamine in the nucleus accumbens, where they likely alter the plasticity of…”
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Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11 by Eriksson, T M, Alvarsson, A, Stan, T L, Zhang, X, Hascup, K N, Hascup, E R, Kehr, J, Gerhardt, G A, Warner-Schmidt, J, Arango-Lievano, M, Kaplitt, M G, Ögren, S O, Greengard, P, Svenningsson, P

“…Cognitive impairments are common in depression and involve dysfunctional serotonin neurotransmission. The 5-HT 1B receptor (5-HT 1B R) regulates serotonin…”
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Structural Basis for the Synthesis of Indirubins as Potent and Selective Inhibitors of Glycogen Synthase Kinase-3 and Cyclin-Dependent Kinases by Polychronopoulos, Panagiotis, Magiatis, Prokopios, Skaltsounis, Alexios-Leandros, Myrianthopoulos, Vassilios, Mikros, Emmanuel, Tarricone, Aldo, Musacchio, Andrea, Roe, S. Mark, Pearl, Laurence, Leost, Maryse, Greengard, Paul, Meijer, Laurent

“…Pharmacological inhibitors of glycogen synthase kinase-3 (GSK-3) and cyclin-dependent kinases have a promising potential for applications against several…”
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p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli by Hanada, Y, Kawahara, Y, Ohnishi, Y N, Shuto, T, Kuroiwa, M, Sotogaku, N, Greengard, P, Sagi, Y, Nishi, A

“…A recent study showed that p11 expressed in cholinergic interneurons (CINs) of the nucleus accumbens (NAc) is a key regulator of depression-like behaviors…”
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Abstract # 1792 Peripheral inflammatory mediators and p11 levels in peripheral blood mononuclear cells from patients with Parkinson’s disease by Green, H.F, Brodin, L, Greengard, P, Berg, L, Svenningsson, P

“…Mood and cognitive impairment associated with Parkinson’s disease (PD) represents a healthcare problem, with between 50 and 70% of PD patients suffering from…”
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Strain-specific regulation of striatal phenotype in Drd2-eGFP BAC transgenic mice by Chan, C Savio, Peterson, Jayms D, Gertler, Tracy S, Glajch, Kelly E, Quintana, Ruth E, Cui, Qiaoling, Sebel, Luke E, Plotkin, Joshua L, Shen, Weixing, Heiman, Myriam, Heintz, Nathaniel, Greengard, Paul, Surmeier, D James

“…Mice carrying bacterial artificial chromosome (BAC) transgenes have become important tools for neuroscientists, providing a powerful means of dissecting…”
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Preliminary evidence that early reduction in p11 levels in natural killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram by Svenningsson, P, Berg, L, Matthews, D, Ionescu, D F, Richards, E M, Niciu, M J, Malinger, A, Toups, M, Manji, H, Trivedi, M H, Zarate, C A, Greengard, P

“…The prediction of treatment response in many neuropsychiatric disorders would be facilitated by easily accessible biomarkers. Using flow cytometry, we herein…”
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Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5 by Norrholm, S.D., Bibb, J.A., Nestler, E.J., Ouimet, C.C., Taylor, J.R., Greengard, P.

“…Repeated exposure to cocaine produces an enduring increase in dendritic spine density in adult rat nucleus accumbens. It has been shown previously that chronic…”
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Structural Domains Involved in the Regulation of Transmitter Release by Synapsins by Hilfiker, Sabine, Benfenati, Fabio, Doussau, Frederic, Nairn, Angus C, Czernik, Andrew J, Augustine, George J, Greengard, Paul

“…Synapsins are a family of neuron-specific phosphoproteins that regulate neurotransmitter release by associating with synaptic vesicles. Synapsins consist of a…”
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