Molecular factors that determine Curie spin relaxation in dysprosium complexes

Molecular factors that determine Curie spin relaxation in dysprosium complexes

Dysprosium complexes can serve as transverse relaxation (T2) agents for water protons through chemical exchange and the Curie spin relaxation mechanism. Using a pair of matched dysprosium(III) complexes, Dy‐L1 (contains one inner‐sphere water) and Dy‐L2 (no inner‐sphere water), it is shown that the...

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Published in:Magnetic resonance in medicine Vol. 46; no. 5; pp. 917 - 922
Main Authors: Caravan, P., Greenfield, M.T., Bulte, J.W.M.
Format: Journal Article
Language:English
Published: New York John Wiley & Sons, Inc 01-11-2001
Williams & Wilkins
Subjects:
albumin
Biological and medical sciences
Contrast Media
Curie spin
dysprosium
Dysprosium - chemistry
human serum
Humans
inner-sphere
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging - methods
Medical sciences
Miscellaneous. Technology
out-sphere
Radiodiagnosis. Nmr imagery. Nmr spectrometry
relaxation
Serum Albumin
T2 contrast agent
Water
water exchange
Water
Human
Chemical exchange
Paramagnetic contrast agent
Serum albumin
Relaxation time
Chemical shift
Dysprosium complex
Spin relaxation
Inner sphere
Proton
Kinetics
Technique
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Summary:Dysprosium complexes can serve as transverse relaxation (T2) agents for water protons through chemical exchange and the Curie spin relaxation mechanism. Using a pair of matched dysprosium(III) complexes, Dy‐L1 (contains one inner‐sphere water) and Dy‐L2 (no inner‐sphere water), it is shown that the transverse relaxation of bulk water is predominantly an inner‐sphere effect. The kinetics of water exchange at Dy‐L1 were determined by 17O NMR. Proton transverse relaxation by Dy‐L1 at high fields is governed primarily through a large chemical shift difference between free and bound water. Dy‐L1 forms a noncovalent adduct with human serum albumin which dramatically lengthens the rotational correlation time, τR, causing the dipole–dipole component of the Curie spin mechanism to become significant and transverse relaxivity to increase by 3–8 times that of the unbound chelate. These findings aid in the design of new molecular species as efficient r2 agents. Magn Reson Med 46:917–922, 2001. Published 2001 Wiley‐Liss, Inc.
Bibliography:ark:/67375/WNG-847BQ8VG-K
This article is a US Government work and, as such, is in the public domain in the United States of America.
istex:F0098610E8D914C9B4D0ADB450718A014243A427
ArticleID:MRM1277
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.1277