Search Results - "Greene, Robert M"

Effects of 5-Aza-2'-deoxycytidine (decitabine) on gene expression by Seelan, Ratnam S, Mukhopadhyay, Partha, Pisano, M Michele, Greene, Robert M

“…5-Aza-2'-deoxycytidine (AzaD), also known as Decitabine, is a deoxycytidine analog that is typically used to activate methylated and silenced genes by promoter…”
Get full text

Cigarette smoke induces proteasomal-mediated degradation of DNA methyltransferases and methyl CpG-/CpG domain-binding proteins in embryonic orofacial cells by Mukhopadhyay, Partha, Greene, Robert M., Pisano, M. Michele

“…•We demonstrated that cigarette smoke extract (CSE) reduces global DNA methylation in primary cultures of first branchial arch-derived cells (1-BA cells),…”
Get full text

MicroRNAs as Biomarkers for Birth Defects by Seelan, Ratnam S, Pisano, M Michele, Greene, Robert M

“…It is estimated that 2-4% of live births will have a birth defect (BD). The availability of biomarkers for the prenatal detection of BDs will facilitate early…”
Get more information

MicroRNA-Mediated Regulation of BMP Signaling in the Developing Neural Tube by Mukhopadhyay, Partha, Seelan, Ratnam S, Greene, Robert M, Pisano, M Michele

“…Neural tube (NT) morphogenesis is reliant on the proper temporospatial expression of numerous genes and synchronized crosstalk between diverse signaling…”
Get more information

Palate morphogenesis: Current understanding and future directions by Greene, Robert M., Pisano, M. Michele

“…In the past, most scientists conducted their inquiries of nature via inductivism, the patient accumulation of “pieces of information” in the pious hope that…”
Get full text

MicroRNA expression profiling of the developing murine upper lip by Warner, Dennis R., Mukhopadhyay, Partha, Brock, Guy, Webb, Cindy L., Michele Pisano, M., Greene, Robert M.

“…Clefts of the lip and palate are thought to be caused by genetic and environmental insults but the role of epigenetic mechanisms underlying this common birth…”
Get full text

Deciphering TGF‐β3 function in medial edge epithelium specification and fusion during mouse secondary palate development by Jin, Jiu‐Zhen, Warner, Dennis R., Lu, Qingxian, Pisano, M. Michele, Greene, Robert M., Ding, Jixiang

“…Background: Transforming growth factor‐β3 (TGF‐β3) plays a central role in mediating secondary palate fusion along the facial midline. However, the mechanisms…”
Get full text

MicroRNAs as Epigenetic Targets of Cigarette Smoke During Embryonic Development by Seelan, Ratnam S, Greene, Robert M, Pisano, Michele M

“…The adverse developmental effects of exposure to Cigarette Smoke (CS) during pregnancy are documented in this paper. These include low birth weight, congenital…”
Get more information

Gene expression changes in the secondary palate and mandible of Prdm16 ⁻/⁻ mice by Warner, Dennis R, Wells, Justin P, Greene, Robert M, Pisano, M. Michele

“…Loss of Prdm16 expression in the mouse leads to a complete cleft of the secondary palate. We have now determined changes in gene expression in the secondary…”
Get full text

Neurobehavioral phenotype of C57BL/6J mice prenatally and neonatally exposed to cigarette smoke by Amos-Kroohs, Robyn M, Williams, Michael T, Braun, Amanda A, Graham, Devon L, Webb, Cynthia L, Birtles, Todd S, Greene, Robert M, Vorhees, Charles V, Pisano, M. Michele

“…Abstract Although maternal cigarette smoking during pregnancy is a well-documented risk factor for a variety of adverse pregnancy outcomes, how prenatal…”
Get full text

Developmental microRNA expression profiling of murine embryonic orofacial tissue by Mukhopadhyay, Partha, Brock, Guy, Pihur, Vasyl, Webb, Cynthia, Pisano, M. Michele, Greene, Robert M.

“…BACKGROUND: Orofacial development is a multifaceted process involving precise, spatio‐temporal expression of a panoply of genes. MicroRNAs (miRNAs), the…”
Get full text

An animal model of cigarette smoke-induced in utero growth retardation by Esposito, Emily R, Horn, Kristin H, Greene, Robert M, Pisano, M. Michele

“…Abstract Maternal/fetal genetic constitution and environmental factors are vital to delivery of a healthy baby. In the United States (US), a low birth weight…”
Get full text

Arsenate-induced apoptosis in murine embryonic maxillary mesenchymal cells via mitochondrial-mediated oxidative injury by Singh, Saurabh, Greene, Robert M., Pisano, M. Michele

“…BACKGROUND: Arsenic is a ubiquitous element that is a potential carcinogen and teratogen and can cause adverse developmental outcomes. Arsenic exerts its toxic…”
Get full text

MicroRNAs as epigenetic regulators of orofacial development by Seelan, Ratnam S., Pisano, M. Michele, Greene, Robert M.

“…Environmental and genetic factors contribute significantly to the etiology of orofacial clefting, which is one of the most common of human congenital…”
Get full text

BMP signaling dynamics in embryonic orofacial tissue by Mukhopadhyay, Partha, Webb, Cynthia L., Warner, Dennis R., Greene, Robert M., Pisano, M. Michele

“…The bone morphogenetic protein (BMP) family represents a class of signaling molecules, that plays key roles in morphogenesis, cell proliferation, survival and…”
Get full text

MicroRNA targeting of the non‐canonical planar cell polarity pathway in the developing neural tube by Mukhopadhyay, Partha, Greene, Robert M., Pisano, M. Michele

“…MicroRNAs (miRNAs) provide context‐dependent transcriptional regulation of genes comprising signalling networks throughout the developing organism including…”
Get full text

Impact of prenatal arsenate exposure on gene expression in a pure population of migratory cranial neural crest cells by Mukhopadhyay, Partha, Seelan, Ratnam S., Greene, Robert M., Pisano, M. Michele

“…•Isolated pure population of mouse cranial neural crest cells (CNCCs).•Studied the effects of in utero exposure to sodium arsenate on CNCCs.•Reported…”
Get full text

Identification of three novel Smad binding proteins involved in cell polarity by Warner, Dennis R., Pisano, M.Michele, Roberts, Emily A., Greene, Robert M.

“…A yeast two-hybrid screen was utilized to identify novel Smad 3 binding proteins expressed in developing mouse orofacial tissue. Three proteins (Erbin, Par-3,…”
Get full text

Developmental toxicity of e‐cigarette aerosols by Greene, Robert M., Pisano, M. Michele

“…Maternal smoking during pregnancy represents a major public health concern increasing the risk for low birth weight, congenital anomalies, preterm birth, fetal…”
Get full text

Spatiotemporal Expression and Functional Analysis of miRNA-22 in the Developing Secondary Palate by Mukhopadhyay, Partha, Smolenkova, Irina, Seelan, Ratnam S., Pisano, M. Michele, Greene, Robert M.

“…Objective Normal development of the embryonic orofacial region requires precise spatiotemporal coordination between numerous genes. MicroRNAs represent small,…”
Get full text