Search Results - "Greene, Nicholas D.E"

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism by Cabreiro, Filipe, Au, Catherine, Leung, Kit-Yi, Vergara-Irigaray, Nuria, Cochemé, Helena M., Noori, Tahereh, Weinkove, David, Schuster, Eugene, Greene, Nicholas D.E., Gems, David

“…The biguanide drug metformin is widely prescribed to treat type 2 diabetes and metabolic syndrome, but its mode of action remains uncertain. Metformin also…”
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Protein deiminases: New players in the developmentally regulated loss of neural regenerative ability by Lange, Sigrun, Gögel, Stefanie, Leung, Kit-Yi, Vernay, Bertrand, Nicholas, Anthony P., Causey, Corey P., Thompson, Paul R., Greene, Nicholas D.E., Ferretti, Patrizia

“…Spinal cord regenerative ability is lost with development, but the mechanisms underlying this loss are still poorly understood. In chick embryos, effective…”
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Neural tube defects by Greene, Nicholas D E, Copp, Andrew J

“…Neural tube defects (NTDs), including spina bifida and anencephaly, are severe birth defects of the central nervous system that originate during embryonic…”
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EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion by Abdul-Aziz, Noraishah M, Turmaine, Mark, Greene, Nicholas D E, Copp, Andrew J

“…The molecular basis of neural fold adhesion and fusion is a poorly understood aspect of neurulation. Cell surface glycosyl phosphatidylinositol (GPI)-anchored…”
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Host-Microbe Co-metabolism Dictates Cancer Drug Efficacy in C. elegans by Scott, Timothy A., Quintaneiro, Leonor M., Norvaisas, Povilas, Lui, Prudence P., Wilson, Matthew P., Leung, Kit-Yi, Herrera-Dominguez, Lucia, Sudiwala, Sonia, Pessia, Alberto, Clayton, Peter T., Bryson, Kevin, Velagapudi, Vidya, Mills, Philippa B., Typas, Athanasios, Greene, Nicholas D.E., Cabreiro, Filipe

“…Fluoropyrimidines are the first-line treatment for colorectal cancer, but their efficacy is highly variable between patients. We queried whether gut…”
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Inositol prevents folate-resistant neural tube defects in the mouse by Greene, Nicholas D.E, Copp, Andrew J

“…Clinical trials demonstrate that up to 70% of neural tube defects (NTDs) can be prevented by folic acid supplementation in early pregnancy, whereas the…”
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Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice by Pai, Yun Jin, Leung, Kit-Yi, Savery, Dawn, Hutchin, Tim, Prunty, Helen, Heales, Simon, Brosnan, Margaret E., Brosnan, John T., Copp, Andrew J., Greene, Nicholas D.E.

“…Glycine decarboxylase (GLDC) acts in the glycine cleavage system to decarboxylate glycine and transfer a one-carbon unit into folate one-carbon metabolism…”
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Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure by Leung, Kit-Yi, Pai, Yun Jin, Chen, Qiuying, Santos, Chloe, Calvani, Enrica, Sudiwala, Sonia, Savery, Dawn, Ralser, Markus, Gross, Steven S., Copp, Andrew J., Greene, Nicholas D.E.

“…Abnormal folate one-carbon metabolism (FOCM) is implicated in neural tube defects (NTDs), severe malformations of the nervous system. MTHFR mediates…”
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Impaired folate 1-carbon metabolism causes formate-preventable hydrocephalus in glycine decarboxylase-deficient mice by Santos, Chloe, Pai, Yun Jin, Mahmood, M Raasib, Leung, Kit-Yi, Savery, Dawn, Waddington, Simon N, Copp, Andrew J, Greene, Nicholas DE

“…Ventriculomegaly and hydrocephalus are associated with loss of function of glycine decarboxylase (Gldc) in mice and in humans suffering from non-ketotic…”
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Inositol, neural tube closure and the prevention of neural tube defects by Greene, Nicholas D.E., Leung, Kit‐Yi, Copp, Andrew J.

“…Susceptibility to neural tube defects (NTDs), such as anencephaly and spina bifida is influenced by genetic and environmental factors including maternal…”
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The actions of methotrexate on endothelial cells are dependent on the shear stress-induced regulation of one carbon metabolism by Lang, Marie B, Leung, Kit-Yi, Greene, Nicholas D E, Malone, Kerri M, Saginc, Gaye, Randi, Anna M, Kiprianos, Allan, Maughan, Robert T, Pericleous, Charis, Mason, Justin C

“…The disease-modifying anti-rheumatic drug methotrexate (MTX) is recognized to reduce cardiovascular risk in patients with systemic inflammatory diseases…”
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A coming of age: advanced imaging technologies for characterising the developing mouse by Norris, Francesca C, Wong, Michael D, Greene, Nicholas D.E, Scambler, Peter J, Weaver, Tom, Weninger, Wolfgang J, Mohun, Timothy J, Henkelman, R. Mark, Lythgoe, Mark F

“…Highlights • International efforts are coming together to undertake mouse embryo phenotyping. • State-of-the-art 3D imaging has the potential to expedite this…”
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The arginine methyltransferase Carm1 is necessary for heart development by Jamet, Sophie, Ha, Seungshin, Ho, Tzu-Hua, Houghtaling, Scott, Timms, Andrew, Yu, Kai, Paquette, Alison, Maga, Ali Murat, Greene, Nicholas D E, Beier, David R

“…Abstract To discover genes implicated in human congenital disorders, we performed ENU mutagenesis in the mouse and screened for mutations affecting embryonic…”
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Dolutegravir in pregnant mice is associated with increased rates of fetal defects at therapeutic but not at supratherapeutic levels by Mohan, Haneesha, Lenis, Monica Guzman, Laurette, Evelyn Y., Tejada, Oscar, Sanghvi, Tanvi, Leung, Kit-Yi, Cahill, Lindsay S., Sled, John G., Delgado-Olguín, Paul, Greene, Nicholas D.E., Copp, Andrew J., Serghides, Lena

“…Dolutegravir (DTG) is a preferred regimen for all people with HIV including pregnant women, but its effects on the fetus are not fully understood…”
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Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans by Narisawa, Ayumi, Komatsuzaki, Shoko, Kikuchi, Atsuo, Niihori, Tetsuya, Aoki, Yoko, Fujiwara, Kazuko, Tanemura, Mitsuyo, Hata, Akira, Suzuki, Yoichi, Relton, Caroline L., Grinham, James, Leung, Kit-Yi, Partridge, Darren, Robinson, Alexis, Stone, Victoria, Gustavsson, Peter, Stanier, Philip, Copp, Andrew J., Greene, Nicholas D.E., Tominaga, Teiji, Matsubara, Yoichi, Kure, Shigeo

“…Neural tube defects (NTDs), including spina bifida and anencephaly, are common birth defects of the central nervous system. The complex multigenic causation of…”
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Apoptosis is not required for mammalian neural tube closure by Massa, Valentina, Savery, Dawn, Ybot-Gonzalez, Patricia, Ferraro, Elisabetta, Rongvaux, Anthony, Cecconi, Francesco, Flavell, Richard, Greene, Nicholas D.E, Copp, Andrew J

“…Apoptotic cell death occurs in many tissues during embryonic development and appears to be essential for processes including digit formation and cardiac…”
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The emerging role of epigenetic mechanisms in the etiology of neural tube defects by Greene, Nicholas D.E., Stanier, Philip, Moore, Gudrun E.

“…The molecular requirements for neural tube closure are complex. This is illustrated by the occurrence of neural tube defects (NTDs) in many genetic mouse…”
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Gene–environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function by Burren, Katie A., Savery, Dawn, Massa, Valentina, Kok, Robert M., Scott, John M., Blom, Henk J., Copp, Andrew J., Greene, Nicholas D.E.

“…Risk of neural tube defects (NTDs) is determined by genetic and environmental factors, among which folate status appears to play a key role. However, the…”
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In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A by Ivanova, Anna, Signore, Massimo, Caro, Nadia, Greene, Nicholas D.E., Copp, Andrew J., Martinez-Barbera, Juan Pedro

“…We generated a ROSA26‐eGFP‐DTA mouse line by introducing an eGFP‐DTA (enhanced green fluorescent protein – diphtheria toxin fragment A) cassette into the…”
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Mouse models of neural tube defects: Investigating preventive mechanisms by Greene, Nicholas D.E., Copp, Andrew J.

“…Neural tube defects (NTD), including anencephaly and spina bifida, are a group of severe congenital abnormalities in which the future brain and/or spinal cord…”
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