Search Results - "Greene, Mark H."

Malignancies and survival patterns in the National Cancer Institute inherited bone marrow failure syndromes cohort study by Alter, Blanche P., Giri, Neelam, Savage, Sharon A., Peters, June A., Loud, Jennifer T., Leathwood, Lisa, Carr, Ann G., Greene, Mark H., Rosenberg, Philip S.

“…Summary Fanconi anaemia (FA), dyskeratosis congenita (DC), Diamond‐Blackfan anaemia (DBA), and Shwachman‐Diamond syndrome (SDS) comprise major inherited bone…”
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Pathologic findings at risk-reducing salpingo-oophorectomy: primary results from Gynecologic Oncology Group Trial GOG-0199 by Sherman, Mark E, Piedmonte, Marion, Mai, Phuong L, Ioffe, Olga B, Ronnett, Brigitte M, Van Le, Linda, Ivanov, Iouri, Bell, Maria C, Blank, Stephanie V, DiSilvestro, Paul, Hamilton, Chad A, Tewari, Krishnansu S, Wakeley, Katie, Kauff, Noah D, Yamada, S Diane, Rodriguez, Gustavo, Skates, Steven J, Alberts, David S, Walker, Joan L, Minasian, Lori, Lu, Karen, Greene, Mark H

“…Risk-reducing salpingo-oophorectomy (RRSO) lowers mortality from ovarian/tubal and breast cancers among BRCA1/2 mutation carriers. Uncertainties persist…”
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Diabetes, metformin and cancer risk in myotonic dystrophy type I by Alsaggaf, Rotana, Pfeiffer, Ruth M., Wang, Youjin, St. George, Diane Marie M., Zhan, Min, Wagner, Kathryn R., Amr, Sania, Greene, Mark H., Gadalla, Shahinaz M.

“…Myotonic dystrophy type I (DM1) is an autosomal dominant multisystem disorder characterized by myotonia and muscle weakness. Type 2 diabetes (T2D) and cancer…”
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Cancer phenotype in myotonic dystrophy patients: Results from a meta‐analysis by Emparanza, Jose I., López de Munain, Adolfo, Greene, Mark H., Matheu, Ander, Fernández‐Torrón, Roberto, Gadalla, Shahinaz M.

“…ABSTRACT Introduction: Recent studies have provided evidence that patients with myotonic dystrophy (DM) are at excess risk of cancer. However, inconsistencies…”
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In their own words: treating very young BRCA1/2 mutation-positive women with care and caution by Hoskins, Lindsey M, Werner-Lin, Allison, Greene, Mark H

“…Young women who have been identified as carrying a deleterious mutation in BRCA1 or BRCA2 face a unique set of challenges related to managing cancer risk…”
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Does bilateral salpingectomy with ovarian retention warrant consideration as a temporary bridge to risk-reducing bilateral oophorectomy in BRCA1/2 mutation carriers? by Greene, Mark H., MD, Mai, Phuong L., MD, MS, Schwartz, Peter E., MD

“…Risk-reducing salpingo-oophorectomy (RRSO) is the most definitive surgical intervention for ovarian cancer risk reduction among BRCA1/2 mutation carriers. For…”
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Mosaic chromosome Y loss and testicular germ cell tumor risk by Machiela, Mitchell J, Dagnall, Casey L, Pathak, Anand, Loud, Jennifer T, Chanock, Stephen J, Greene, Mark H, McGlynn, Katherine A, Stewart, Douglas R

“…Studies have suggested mosaic loss of chromosome Y (mLOY) in blood-derived DNA is common in older men. Cohort studies investigating mLOY and mortality have…”
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Peritoneal carcinomatosis after risk‐reducing surgery in BRCA1/2 mutation carriers by Harmsen, Marline G., Piek, Jurgen M. J., Bulten, Johan, Casey, Murray J., Rebbeck, Timothy R., Mourits, Marian J., Greene, Mark H., Slangen, Brigitte F. M., van Beurden, Marc, Massuger, Leon F. A. G., Hoogerbrugge, Nicoline, de Hullu, Joanne A.

“…BACKGROUND Risk‐reducing salpingo‐oophorectomy (RRSO) is recommended for BRCA1/2 mutation carriers because of their increased risk of ovarian carcinoma…”
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A Clinical Service to Support the Return of Secondary Genomic Findings in Human Research by Darnell, Andrew J., Austin, Howard, Bluemke, David A., Cannon, Richard O., Fischbeck, Kenneth, Gahl, William, Goldman, David, Grady, Christine, Greene, Mark H., Holland, Steven M., Hull, Sara Chandros, Porter, Forbes D., Resnik, David, Rubinstein, Wendy S., Biesecker, Leslie G.

“…Human genome and exome sequencing are powerful research tools that can generate secondary findings beyond the scope of the research. Most secondary genomic…”
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Potential Usefulness of Single Nucleotide Polymorphisms to Identify Persons at High Cancer Risk: An Evaluation of Seven Common Cancers by PARK, Ju-Hyun, GAIL, Mitchell H, GREENE, Mark H, CHATTERJEE, Nilanjan

“…To estimate the likely number and predictive strength of cancer-associated single nucleotide polymorphisms (SNPs) that are yet to be discovered for seven…”
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Ovarian cancer screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial: Findings from the initial screen of a randomized trial by Buys, Saundra S., Partridge, Edward, Greene, Mark H., Prorok, Philip C., Reding, Douglas, Riley, Thomas L., Hartge, Patricia, Fagerstrom, Richard M., Ragard, Lawrence R., Chia, David, Izmirlian, Grant, Fouad, Mona, Johnson, Christine C., Gohagan, John K.

“…Ovarian cancer screening with transvaginal ultrasound (TVU) and CA-125 was evaluated in the Prostate, Lung, Colorectal and Ovarian (PLCO) Trial. This was a…”
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Quantifying cancer absolute risk and cancer mortality in the presence of competing events after a myotonic dystrophy diagnosis by Gadalla, Shahinaz M, Pfeiffer, Ruth M, Kristinsson, Sigurdur Y, Björkholm, Magnus, Hilbert, James E, Moxley, 3rd, Richard T, Landgren, Ola, Greene, Mark H

“…Recent studies show that patients with myotonic dystrophy (DM) have an increased risk of specific malignancies, but estimates of absolute cancer risk…”
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Challenges related to developing serum-based biomarkers for early ovarian cancer detection by Mai, Phuong L, Wentzensen, Nicolas, Greene, Mark H

“…In this issue of the journal, Cramer and colleagues and Zhu and colleagues report carefully designed phase 3 assessments of candidate ovarian cancer screening…”
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Familial testicular germ cell tumors in adults: 2010 summary of genetic risk factors and clinical phenotype by Greene, Mark H, Kratz, Christian P, Mai, Phuong L, Mueller, Christine, Peters, June A, Bratslavsky, Gennady, Ling, Alex, Choyke, Peter M, Premkumar, Ahalya, Bracci, Janet, Watkins, Rissah J, McMaster, Mary Lou, Korde, Larissa A

“…Familial aggregations of testicular germ cell tumor (FTGCT) have been well described, suggesting the existence of a hereditary TGCT subset. Approximately 1.4%…”
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A Prospective Study of Risk-Reducing Salpingo-oophorectomy and Longitudinal CA-125 Screening among Women at Increased Genetic Risk of Ovarian Cancer: Design and Baseline Characteristics: A Gynecologic Oncology Group Study by GREENE, Mark H, PIEDMONTE, Marion, BOGGESS, John, SCHWARTZ, Peter E, KELLEY, Joseph L, WAKELEY, Katie E, MINASIAN, Lori, SKATES, Stephen, ALBERTS, Dave, GAIL, Mitchell, HENSLEY, Martee, MINER, Zoe, MAI, Phuong L, LOUD, Jennifer, RODRIGUEZ, Gustavo, BASIL, Jack

“…Background: Women who are genetically predisposed to ovarian cancer are at very high risk of developing this disease. Although risk-reducing…”
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Prophylactic Oophorectomy Reduces Breast Cancer Penetrance During Prospective, Long-Term Follow-Up of BRCA1 Mutation Carriers by KRAMER, Joan L, VELAZQUEZ, Isela A, CHEN, Bingshu E, ROSENBERG, Philip S, STRUEWING, Jeffery P, GREENE, Mark H

“…Breast cancer penetrance estimates in BRCA1 mutation carriers have varied from 40% to 85%; this heterogeneity has been attributed to variations in risk among…”
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Hypothesis: neoplasms in myotonic dystrophy by Mueller, Christine M, Hilbert, James E, Martens, William, Thornton, Charles A, Moxley, Richard T. III, Greene, Mark H

“…Tumorigenesis is a multi-step process due to an accumulation of genetic mutations in multiple genes in diverse pathways which ultimately lead to loss of…”
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Reproductive Cancer Risk Factors in Women With Myotonic Dystrophy (DM): Survey Data From the US and UK DM Registries by Higgs, Cecilia, Hilbert, James E., Wood, Libby, Martens, William B., Marini-Bettolo, Chiara, Nikolenko, Nikoletta, Alsaggaf, Rotana, Lochmüller, Hanns, Moxley, Richard T., Greene, Mark H., Wang, Youjin, Gadalla, Shahinaz M.

“…Introduction: Recent evidence demonstrates that women with myotonic dystrophy type 1 are at increased risk of reproductive organ tumors. However, studies of…”
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LINE-1 methylation is inherited in familial testicular cancer kindreds by Mirabello, Lisa, Savage, Sharon A, Korde, Larissa, Gadalla, Shahinaz M, Greene, Mark H

“…Testicular germ cell tumors (TGCT) are the most frequent cancers among young men. There is a clear familial component to TGCT etiology, but no high-penetrance…”
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Cancer Risk in Myotonic Dystrophy Type I: Evidence of a Role for Disease Severity by Alsaggaf, Rotana, St. George, Diane Marie M, Zhan, Min, Pfeiffer, Ruth M, Wang, Youjin, Wagner, Kathryn R, Greene, Mark H, Amr, Sania, Gadalla, Shahinaz M

“…Abstract Background Myotonic dystrophy type 1 (DM1) is an inherited trinucleotide repeat disorder in which specific cancers have been implicated as part of the…”
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