Search Results - "Greene, Kellee"

Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8⁺ T-cell axis by Brackett, Craig M., Kojouharov, Bojidar, Veith, Jean, Greene, Kellee F., Burdelya, Lyudmila G., Gollnick, Sandra O., Abrams, Scott I., Gudkov, Andrei V.

“…Activation of an anticancer innate immune response is highly desirable because of its inherent ability to generate an adaptive antitumor T-cell response…”
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Resistance of bone marrow stroma to genotoxic preconditioning is determined by p53 by Fedtsova, Natalia, Komarova, Elena A., Greene, Kellee F., Novototskaya, Liliya R., Molodtsov, Ivan, Brackett, Craig M., Strom, Evguenia, Gleiberman, Anatoli S., Shakhov, Alexander N., Gudkov, Andrei V.

“…Transplantation of bone marrow (BM) is made possible by the differential sensitivity of its stromal and hematopoietic components to preconditioning by…”
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Signaling through TLR5 mitigates lethal radiation damage by neutrophil-dependent release of MMP-9 by Brackett, Craig M., Greene, Kellee F., Aldrich, Alyssa R., Trageser, Nicholas H., Pal, Srabani, Molodtsov, Ivan, Kandar, Bojidar M., Burdelya, Lyudmila G., Abrams, Scott I., Gudkov, Andrei V.

“…Acute radiation syndrome (ARS) is a major cause of lethality following radiation disasters. A TLR5 agonist, entolimod, is among the most powerful experimental…”
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Singlet Oxygen-Induced DNA Damage by DeFedericis, Han-Chun, Patrzyc, Helen B., Rajecki, Michael J., Budzinski, Edwin E., Iijima, Herbert, Dawidzik, Jean B., Evans, Marianne S., Greene, Kellee F., Box, Harold C.

“…DeFedericis, H-C., Patrzyc, H. B., Rajecki, M. J., Budzinski, E. E., Iijima, H., Dawidzik, J. B., Evans, M. S., Greene, K. F. and Box, H. C. Singlet…”
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Assessment of DNA Damage at the Dimer Level: Measurement of the Formamide Lesion by Greene, Kellee F., Budzinski, Edwin E., Iijima, Herbert, Dawidzik, Jean B., DeFedericis, Han-Chun, Patrzyc, Helen B., Evans, Marianne S., Bailey, Douglas T., Freund, Harold G., Box, Harold C.

“…Greene, K. F., Budzinski, E. E., Iijima, H., Davidzik, J. B., DeFedericis, H-C., Patrzyc, H. B., Evans, M. S., Bailey, D. T., Freund, H. F. and Box, H. C…”
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Entolimod, a clinical stage flagellin derivative, improves clinically relevant chemo-immunotherapy responses in pre-clinical triple negative breast cancer by Brackett, Craig, Aldrich, Alyssa, Punch, Patrick, Greene, Kellee, Molodtsov, Ivan, Gudkov, Andrei, Abrams, Scott

“…Abstract Chemotherapy+anti-PD-1 is FDA approved and has improved outcomes for locally advanced and metastatic PD-L1+ triple negative breast cancer (TNBC)…”
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A Novel Approach to DNA Damage Assessments: Measurement of the Thymine Glycol Lesion by Bailey, Douglas T., DeFedericis, Han-Chun C., Greene, Kellee F., Iijima, Herbert, Budzinski, Edwin E., Patrzyc, Helen B., Dawidzik, Jean B., Box, Harold C.

“…Bailey, D. T., DeFedericis, H-C. C., Greene, K. F., Iijima, H., Budzinski, E. E., Patrzyc, H. B., Dawidzik, J. B. and Box, H. C. A Novel Approach to DNA Damage…”
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Abstract P4-04-02: A clinical-stage toll-like receptor 5 agonist, entolimod, boosts chemo-immunotherapy in pre-clinical TNBC by generating durable antitumor immunity by Brackett, Craig M, Aldrich, Alyssa R, Greene, Kellee F, Kandar, Bojidar, Veith, Jean, Burdelya, Lyudmila G, Abrams, Scott I., Gudkov, Andrei V

“…Abstract Triple-negative breast cancer (TNBC) accounts for 15-20% of all breast cancer diagnoses, is the most aggressive form of the disease, and has the…”
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A Toll-like Receptor 5 agonist entolimod mitigates radiation damage through a neutrophil-dependent mechanism by Brackett, Craig M, Greene, Kellee, Kandar, Bojidar, Trageser, Nicholas, Kandefer, Rachel, Pal, Srabani, Burdelya, Lyudmila, Gudkov, Andrei

“…Abstract The increased risk of exposure to life-threating nuclear and radiation emergencies warrants the development of FDA-approved medical radiation…”
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Entolimod, a clinical-stage TLR5 agonist, activates antitumor T cell immunity against liver and lung metastases through distinct mechanisms by Brackett, Craig M, Kojouharov, Bojidar, Greene, Kellee, Trageser, Nicholas, Gollnick, Sandra, Burdelya, Lyudmila, Abrams, Scott I, Gudkov, Andrei

“…Abstract Innate immune modulators can generate an antitumor T cell response. However, significant toxicities associated with systemic administration have…”
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A Toll-like receptor (TLR) 5 agonist entolimod mediates anti-metastatic activity via NK cell-dependent T cell activation (TUM2P.1029) by Brackett, Craig, Kojouharov, Bojidar, Veith, Jean, Greene, Kellee, Gollnick, Sandra, Burdelya, Lyudmila, Abrams, Scott, Gudkov, Andrei

“…Abstract Directing innate immunity against cancer is a promising but poorly developed approach to immunotherapy due to the risk of acute inflammation induced…”
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Abstract LB-166: Characterization of a novel class of carbazole based radiation sensitizers by Saito, Naoyuki G., Commane, Mairead, Greene, Kellee F., Novototskaya, Liliya R., Purmal, Andrei A., Wang, Zhou, Gurova, Katerina V., Gudkov, Andrei V.

“…Abstract Technological advances in radiation therapy have greatly improved our ability to deliver a precise dose of radiation to a defined volumetric target…”
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