Search Results - "Greene, Geoffrey L"

Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer by Lainé, Muriel, Fanning, Sean W, Chang, Ya-Fang, Green, Bradley, Greene, Marianne E, Komm, Barry, Kurleto, Justyna D, Phung, Linda, Greene, Geoffrey L

“…Endocrine therapy remains the mainstay of treatment for estrogen receptor-positive (ER+) breast cancer. Constitutively active mutations in the ligand binding…”
Get full text

Overcoming mutation-based resistance to antiandrogens with rational drug design by Balbas, Minna D, Evans, Michael J, Hosfield, David J, Wongvipat, John, Arora, Vivek K, Watson, Philip A, Chen, Yu, Greene, Geoffrey L, Shen, Yang, Sawyers, Charles L

“…The second-generation antiandrogen enzalutamide was recently approved for patients with castration-resistant prostate cancer. Despite its success, the duration…”
Get full text

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation by Fanning, Sean W, Mayne, Christopher G, Dharmarajan, Venkatasubramanian, Carlson, Kathryn E, Martin, Teresa A, Novick, Scott J, Toy, Weiyi, Green, Bradley, Panchamukhi, Srinivas, Katzenellenbogen, Benita S, Tajkhorshid, Emad, Griffin, Patrick R, Shen, Yang, Chandarlapaty, Sarat, Katzenellenbogen, John A, Greene, Geoffrey L

“…Somatic mutations in the estrogen receptor alpha (ERα) gene (ESR1), especially Y537S and D538G, have been linked to acquired resistance to endocrine therapies…”
Get full text

Lasofoxifene as a potential treatment for aromatase inhibitor-resistant ER-positive breast cancer by Lainé, Muriel, Greene, Marianne E, Kurleto, Justyna D, Bozek, Grazyna, Leng, Tiffany, Huggins, Rosemary J, Komm, Barry S, Greene, Geoffrey L

“…Breast cancers treated with aromatase inhibitors (AIs) can develop AI resistance, which is often driven by estrogen receptor-alpha (ERα/ESR1) activating…”
Get full text

Selective pressure of endocrine therapy activates the integrated stress response through NFκB signaling in a subpopulation of ER positive breast cancer cells by Semina, Svetlana E, Pal, Purab, Kansara, Nidhi S, Huggins, Rosemary J, Alarid, Elaine T, Greene, Geoffrey L, Frasor, Jonna

“…While estrogen receptor (ER) positive breast tumors generally respond well to endocrine therapy (ET), up to 40% of patients will experience relapse, either…”
Get full text

The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells by Fanning, Sean W, Jeselsohn, Rinath, Dharmarajan, Venkatasubramanian, Mayne, Christopher G, Karimi, Mostafa, Buchwalter, Gilles, Houtman, René, Toy, Weiyi, Fowler, Colin E, Han, Ross, Lainé, Muriel, Carlson, Kathryn E, Martin, Teresa A, Nowak, Jason, Nwachukwu, Jerome C, Hosfield, David J, Chandarlapaty, Sarat, Tajkhorshid, Emad, Nettles, Kendall W, Griffin, Patrick R, Shen, Yang, Katzenellenbogen, John A, Brown, Myles, Greene, Geoffrey L

“…Acquired resistance to endocrine therapy remains a significant clinical burden for breast cancer patients. Somatic mutations in the (estrogen receptor alpha…”
Get full text

ERα/PR crosstalk is altered in the context of the ERα Y537S mutation and contributes to endocrine therapy-resistant tumor proliferation by Huggins, Rosemary J., Greene, Geoffrey L.

“…The constitutively active ESR1 Y537S mutation is associated with endocrine therapy (ET) resistance and progression of metastatic breast cancer through its…”
Get full text

Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer by West, Diana C, Kocherginsky, Masha, Tonsing-Carter, Eva Y, Dolcen, D Nesli, Hosfield, David J, Lastra, Ricardo R, Sinnwell, Jason P, Thompson, Kevin J, Bowie, Kathleen R, Harkless, Ryan V, Skor, Maxwell N, Pierce, Charles F, Styke, Sarah C, Kim, Caroline R, de Wet, Larischa, Greene, Geoffrey L, Boughey, Judy C, Goetz, Matthew P, Kalari, Krishna R, Wang, Liewei, Fleming, Gini F, Györffy, Balázs, Conzen, Suzanne D

“…Although high glucocorticoid receptor (GR) expression in early-stage estrogen receptor (ER)-negative breast cancer is associated with shortened relapse-free…”
Get full text

Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells by Hosfield, David J, Weber, Sandra, Li, Nan-Sheng, Suavage, Madline, Joiner, Carstyn F, Hancock, Govinda R, Sullivan, Emily A, Nduwke, Estelle, Han, Ross, Cush, Sydney, Lainé, Muriel, Mader, Sylvie C, Greene, Geoffrey L, Fanning, Sean W

“…Chemical manipulation of estrogen receptor alpha ligand binding domain structural mobility tunes receptor lifetime and influences breast cancer therapeutic…”
Get full text

The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer by Cocce, Kimberly J., Jasper, Jeff S., Desautels, Taylor K., Everett, Logan, Wardell, Suzanne, Westerling, Thomas, Baldi, Robert, Wright, Tricia M., Tavares, Kendall, Yllanes, Alex, Bae, Yeeun, Blitzer, Jeremy T., Logsdon, Craig, Rakiec, Daniel P., Ruddy, David A., Jiang, Tiancong, Broadwater, Gloria, Hyslop, Terry, Hall, Allison, Laine, Muriel, Phung, Linda, Greene, Geoffrey L., Martin, Lesley-Ann, Pancholi, Sunil, Dowsett, Mitch, Detre, Simone, Marks, Jeffrey R., Crawford, Gregory E., Brown, Myles, Norris, John D., Chang, Ching-yi, McDonnell, Donald P.

“…Notwithstanding the positive clinical impact of endocrine therapies in estrogen receptor-alpha (ERα)-positive breast cancer, de novo and acquired resistance…”
Get full text

Ligand control of coregulator recruitment to nuclear receptors by Nettles, Kendall W, Greene, Geoffrey L

“…Nuclear receptors modulate transcription through ligand-mediated recruitment of transcriptional coregulator proteins. The structural connection between ligand…”
Get full text

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation by Abot, Anne, Fontaine, Coralie, Buscato, Mélissa, Solinhac, Romain, Flouriot, Gilles, Fabre, Aurélie, Drougard, Anne, Rajan, Shyamala, Laine, Muriel, Milon, Alain, Muller, Isabelle, Henrion, Daniel, Adlanmerini, Marine, Valéra, Marie‐Cécile, Gompel, Anne, Gerard, Céline, Péqueux, Christel, Mestdagt, Mélanie, Raymond‐Letron, Isabelle, Knauf, Claude, Ferriere, François, Valet, Philippe, Gourdy, Pierre, Katzenellenbogen, Benita S, Katzenellenbogen, John A, Lenfant, Françoise, Greene, Geoffrey L, Foidart, Jean‐Michel, Arnal, Jean‐François

“…Estetrol (E 4 ) is a natural estrogen with a long half‐life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen…”
Get full text

MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion by Bockhorn, Jessica, Yee, Kathy, Chang, Ya-Fang, Prat, Aleix, Huo, Dezheng, Nwachukwu, Chika, Dalton, Rachel, Huang, Simo, Swanson, Kaitlin E., Perou, Charles M., Olopade, Olufunmilayo I., Clarke, Michael F., Greene, Geoffrey L., Liu, Huiping

“…Metastasis remains a significant challenge in treating cancer. A better understanding of the molecular mechanisms underlying metastasis is needed to develop…”
Get full text

Reinvestigating the Synthesis and Characterization of Ethyl 3‑[5-(2-Ethoxycarbonyl-1-methylvinyloxy)-1-methyl‑1H‑indol-3-yl]-but-2-enoate by Li, Nan-Sheng, Piccirilli, Joseph A., Greene, Geoffrey L.

“…We reinvestigated the reported method for the synthesis of ethyl 3-[5-(2-ethoxycarbonyl-1-methylvinyloxy)-1-methyl-1H-indol-3-yl]-but-2-enoate (MIBE), which…”
Get full text

Plasma Membrane Estrogen Receptors Exist and Functions as Dimers by Razandi, Mahnaz, Pedram, Ali, Merchenthaler, Istvan, Greene, Geoffrey L, Levin, Ellis R

“…A small pool of estrogen receptors (ERα and -β) localize at the plasma membrane and rapidly signal to affect cellular physiology. Although nuclear ERs function…”
Get full text

Capture of associated targets on chromatin links long-distance chromatin looping to transcriptional coordination by Bourgo, Ryan J., Singhal, Hari, Greene, Geoffrey L.

“…Here we describe a sensitive and novel method of identifying endogenous DNA–DNA interactions. Capture of Associated Targets on CHromatin (CATCH) uses efficient…”
Get full text

Structural Basis for an Unexpected Mode of SERM-Mediated ER Antagonism by Wu, Ya-Ling, Yang, Xiaojing, Ren, Zhong, McDonnell, Donald P., Norris, John D., Willson, Timothy M., Greene, Geoffrey L.

“…Tamoxifen is effective for the prevention and treatment of estrogen-dependent breast cancers, but is associated with an increased incidence of endometrial…”
Get full text

Cross-talk between the ligand- and DNA-binding domains of estrogen receptor by Huang, Wei, Greene, Geoffrey L., Ravikumar, Krishnakumar M., Yang, Sichun

“…ABSTRACT Estrogen receptor alpha (ERα) is a hormone‐responsive transcription factor that contains several discrete functional domains, including a…”
Get full text

Mapping ERβ genomic binding sites reveals unique genomic features and identifies EBF1 as an ERβ interactor by Le, Thien P, Sun, Miao, Luo, Xin, Kraus, W Lee, Greene, Geoffrey L

“…Considerable effort by numerous laboratories has resulted in an improved understanding of estrogen and SERM action mediated by the two estrogen receptors, ERα…”
Get full text

Examining the pathogenesis of breast cancer using a novel agent-based model of mammary ductal epithelium dynamics by Chapa, Joaquin, Bourgo, Ryan J, Greene, Geoffrey L, Kulkarni, Swati, An, Gary

“…The study of the pathogenesis of breast cancer is challenged by the long time-course of the disease process and the multi-factorial nature of generating…”
Get full text