Search Results - "Greenberg, RA"

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes by Greenberg, Roger A, Sobhian, Bijan, Pathania, Shailja, Cantor, Sharon B, Nakatani, Yoshihiro, Livingston, David M

“…The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire…”
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Abstract P5-01-06: 18F-radiolabeled PARP-1 inhibitor uptake as a marker of PARP-1 activity in breast cancer by Edmonds, CE, Lieberman, BP, Xu, K, Zeng, C, Makvandi, M, Li, S, Hou, C, Lee, H, Greenberg, RA, Mankoff, DA, Mach, RH

“…Abstract Objectives: The nuclear enzyme PARP-1 plays a central role in sensing DNA damage and facilitating repair. Tumors with BRCA1/2 mutations are highly…”
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BRCA1 Supports XIST RNA Concentration on the Inactive X Chromosome by Ganesan, Shridar, Silver, Daniel P., Greenberg, Roger A., Avni, Dror, Drapkin, Ronny, Miron, Alexander, Mok, Samuel C., Randrianarison, Voahangy, Brodie, Steven, Salstrom, Jennifer, Rasmussen, Theodore P., Klimke, Ann, Marrese, Christine, Marahrens, York, Deng, Chu-Xia, Feunteun, Jean, Livingston, David M.

“…BRCA1, a breast and ovarian tumor suppressor, colocalizes with markers of the inactive X chromosome (Xi) on Xi in female somatic cells and associates with XIST…”
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When health care professionals say "more" and parents say "enough" by Greenberg, R A, Weingarten, K

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Constitutive Telomerase Expression Promotes Mammary Carcinomas in Aging Mice by Artandi, Steven E., Alson, Scott, Tietze, Maja K., Sharpless, Norman E., Ye, Siqin, Greenberg, Roger A., Castrillon, Diego H., Horner, James W., Weiler, Sarah R., Carrasco, Ruben D., DePinho, Ronald A.

“…Telomerase is up-regulated in the vast majority of human cancers and serves to halt the progressive telomere shortening that ultimately blocks would-be cancer…”
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Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse by Greenberg, R A, Chin, L, Femino, A, Lee, K H, Gottlieb, G J, Singer, R H, Greider, C W, DePinho, R A

“…Maintenance of telomere length is predicted to be essential for bypass of senescence and crisis checkpoints in cancer cells. The impact of telomere dysfunction…”
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Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation by GREENBERG, R. A, O'HAGAN, R. C, HONGYU DENG, QIURONG XIAO, HANN, S. R, ADAMS, R. R, LICHTSTEINER, S, CHIN, L, MORIN, G. B, DEPINHO, R. A

“…The telomerase reverse transcriptase component (TERT) is not expressed in most primary somatic human cells and tissues, but is upregulated in the majority of…”
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Telomeres, crisis and cancer by Greenberg, R A

“…Eukaryotic chromosomes terminate in specialized nucleic acid-protein complexes known as telomeres. Disruption of telomere structure by erosion of telomeric DNA…”
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Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation by GREENBERG, R. A, ALLSOPP, R. C, CHIN, L, MORIN, G. B, DEPINHO, R. A

“…We have identified the mouse telomerase reverse transcriptase component (mTERT) and demonstrate both substantial sequence homology to the human ortholog…”
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Effects of High-Intensity Strength Training on Multiple Risk Factors for Osteoporotic Fractures: A Randomized Controlled Trial by Nelson, Miriam E, Fiatarone, Maria A, Morganti, Christina M, Trice, Isaiah, Greenberg, Robert A, Evans, William J

“…Objective.—To determine how multiple risk factors for osteoporotic fractures could be modified by high-intensity strength training exercises in postmenopausal…”
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Mitogen Stimulation Cooperates with Telomere Shortening To Activate DNA Damage Responses and Senescence Signaling by Satyanarayana, A., Greenberg, R. A., Schaetzlein, S., Buer, J., Masutomi, K., Hahn, W. C., Zimmermann, S., Martens, U., Manns, M. P., Rudolph, K. L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Telomere Dysfunction Alters the Chemotherapeutic Profile of Transformed Cells by Lee, Kee-Ho, Rudolph, K. Lenhard, Ju, Yeun-Jin, Greenberg, Roger A., Cannizzaro, Linda, Chin, Lynda, Weiler, Sarah R., DePinho, Ronald A.

“…Telomerase inhibition has been touted as a novel cancer-selective therapeutic goal based on the observation of high telomerase levels in most cancers and the…”
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Screening for diabetes: is it warranted? by Greenberg, Roger A, Sacks, David B

“…Background: Diabetes mellitus is estimated to have a worldwide prevalence of 4.6% and afflict 200 million people. The prevalence is accelerating rapidly and…”
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Telomere structural dynamics in genome integrity control and carcinogenesis by Greenberg, Roger A, Rudolph, K Lenhard

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Potent cyclic urea HIV protease inhibitors with benzofused heterocycles as P2/P2′ groups by Rodgers, James D., Johnson, Barry L., Wang, Haisheng, Greenberg, Roger A., Erickson-Viitanen, Susan, Klabe, Ronald M., Cordova, Beverly C., Rayner, Marlene M., Lam, Gilbert N., Chang, Chong-Hwan

“…A series of benzofused heterocycles was examined to replace the metabolically unstable benzyl alcohol P2/P2′ groups of DMP 323 ( 1). Extremely potent…”
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Pediatric nonenvironmental hypothermia presenting to the emergency department: Episodic spontaneous hypothermia with hyperhidrosis by GREENBERG, RICHARD A, RITTICHIER, KRISTINE K

“…Cases of pediatric nonenvironmental hypothermia are uncommon. When presenting to the emergency department, these patients are often evaluated for possible…”
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Effect of Surgically Induced Weight Loss on Asthma in the Morbidly Obese by Macgregor, AM, Greenberg, RA

“…Forty morbidly obese asthmatic patients who underwent gastric restrictive surgery more than 2 years earlier were evaluated to determine the influence of weight…”
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Urinary cotinine and parent history (questionnaire) as indicators of passive smoking and predictors of lower respiratory illness in infants by Margolis, Peter A., Keyes, Lynette L., Greenberg, Robert A., Bauman, Karl E., LaVange, Lisa M.

“…Studies of the effects of passive smoking on lower respiratory illness (LRI) have relied on questionnaires to measure exposure. We studied the association…”
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Multiple Infundibulocystic Basal Cell Carcinomas: Case Report of Unique Unilateral Presentation by Herman, Alysa R., Busam, Klaus J., Greenberg, Robert A., Nehal, Kishwer S.

“…BACKGROUND Basal cell carcinoma shows a wide spectrum of clinical and histologic appearances. A distinct tumor variant with follicular infundibulocystic…”
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Evaluation of a home-based intervention program to reduce infant passive smoking and lower respiratory illness by GREENBERG, R. A, STRECHER, V. J, GLOVER, L. H, HALEY, N. J, LODA, F. A, BAUMAN, K. E, BOAT, B. W, FOWLER, M. G, KEYES, L. L, DENNY, F. W, CHAPMAN, R. S, STEDMAN, H. C, LAVANGE, L. M

“…We conducted a randomized controlled trial to determine whether a home-based intervention program could reduce infant passive smoking and lower respiratory…”
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