Search Results - "Greenberg, N M"

Prostate Cancer in a Transgenic Mouse by Greenberg, N. M., DeMayo, F., Finegold, M. J., Medina, D., Tilley, W. D., Aspinall, J. O., Cunha, G. R., Donjacour, A. A., Matusik, R. J., Rosen, J. M.

“…Progress toward understanding the biology of prostate cancer has been slow due to the few animal research models available to study the spectrum of this…”
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Conditional activation of FGFR1 in the prostate epithelium induces angiogenesis with concomitant differential regulation of Ang-1 and Ang-2 by WINTER, S. F, ACEVEDO, V. D, GANGULA, R. D, FREEMAN, K. W, SPENCER, D. M, GREENBERG, N. M

“…The expression of fibroblast growth factor receptor (FGFR)-1 correlates with angiogenesis and is associated with prostate cancer (CaP) progression. To more…”
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Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade by HURWITZ, A. A, FOSTER, B. A, KWON, E. D, TRUONG, T, CHOI, E. M, GREENBERG, N. M, BURG, M. B, ALLISON, J. P

“…We have previously shown that antibodies to CTLA-4, an inhibitory receptor on T cells, can be effective at inducing regression of transplantable murine tumors…”
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Enforced epithelial expression of IGF-1 causes hyperplastic prostate growth while negative selection is requisite for spontaneous metastogenesis by Kaplan-Lefko, P J, Sutherland, B W, Evangelou, A I, Hadsell, D L, Barrios, R J, Foster, B A, DeMayo, F, Greenberg, N M

“…The insulin-like growth factor-1 (IGF-1) signaling axis is important for cell growth, differentiation and survival and increased serum IGF is a risk factor for…”
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Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model by FOSTER, B. A, GINGRICH, J. R, KWON, E. D, MADIAS, C, GREENBERG, N. M

“…To develop a syngeneic transplantable system to study immunotherapeutic approaches for the treatment of prostate cancer, three cell lines were established from…”
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The insulin-like growth factor axis and prostate cancer : Lessons from the transgenic adenocarcinoma of mouse prostate (TRAMP) model by KAPLAN, P. J, MOHAN, S, COHEN, P, FOSTER, B. A, GREENBERG, N. M

“…We have characterized the temporal expression of the insulin-like growth factor (IGF) axis in the transgenic adenocarcinoma of mouse prostate (TRAMP) model as…”
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The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice by Greenberg, N M, DeMayo, F J, Sheppard, P C, Barrios, R, Lebovitz, R, Finegold, M, Angelopoulou, R, Dodd, J G, Duckworth, M L, Rosen, J M

“…An expression cassette carrying 426 basepairs of the rat probasin (PB) gene promoter and 28 basepairs of 5'-untranslated region is sufficient to target the…”
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Metastatic prostate cancer in a transgenic mouse by GINGRICH, J. R, BARRIOS, R. J, MORTON, R. A, BOYCE, B. F, DEMAYO, F. J, FINEGOLD, M. J, ANGELOPOULOU, R, ROSEN, J. M, GREENBERG, N. M

“…We have previously reported the development of a transgenic mouse model for prostate cancer derived from PB-Tag transgenic line 8247, henceforth designated the…”
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Androgen-independent prostate cancer progression in the TRAMP model by GINGRICH, J. R, BARRIOS, R. J, KATTAN, M. W, NAHM, H. S, FINEGOLD, M. J, GREENBERG, N. M

“…We previously established the autochthonous transgenic adenocarcinoma mouse prostate (TRAMP) model to facilitate characterization of molecular mechanisms…”
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Chemoprevention of prostate carcinogenesis by α-difluoromethylornithine in TRAMP mice by GUPTA, Sanjay, AHMAD, Nihal, MARENGO, Susan R, MACLENNAN, Gregory T, GREENBERG, Norman M, MUKHTAR, Hasan

“…Development of effective chemopreventive agents for human consumption requires conclusive evidence of their efficacy in animal models that have relevance to…”
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E-7869 (R-flurbiprofen) inhibits progression of prostate cancer in the TRAMP mouse by WECHTER, W. J, LEIPOLD, D. D, MURRAY, E. D, QUIGGLE, D, MCCRACKEN, J. D, BARRIOS, R. S, GREENBERG, N. M

“…E-7869 (R-flurbiprofen) is a single enantiomer of a racemic nonsteroidal anti-inflammatory drug. E-7869 does not inhibit either cyclooxygenase-1 or…”
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Pathologic progression of autochthonous prostate cancer in the TRAMP model by Gingrich, J R, Barrios, R J, Foster, B A, Greenberg, N M

“…The ability to manipulate gene expression in specific cell types at specific times utilizing transgenic technology has allowed the development of novel mouse…”
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A transgenic mouse prostate cancer model by Gingrich, J R, Greenberg, N M

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A Role for Phospholipase C-γ-mediated Signaling in Tumor Cell Invasion by KASSIS, J, MOELLINGER, J, HAN LO, GREENBERG, N. M, KIM, H.-G, WELLS, A

“…The invasive and metastatic transformation of cancers often results in death. However, the mechanisms that promote this transformation remain unclear. Two…”
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Early castration reduces prostatic carcinogenesis in transgenic mice by Eng, Marvin H, Charles, Linda G, Ross, Brian D, Chrisp, Clarence E, Pienta, Kenneth J, Greenberg, Norman M, Hsu, Chun X, Sanda, Martin G

“…Objectives. To test the hypothesis that transgenic mouse models of prostate cancer could be useful for testing chemoprevention strategies by evaluating the…”
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Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line by GHOSH, P. M, GHOSH-CHOUDHURY, N, MOYER, M. L, MOTT, G. E, THOMAS, C. A, FOSTER, B. A, GREENBERG, N. M, KREISBERG, J. I

“…Prostate cancer cells derived from transgenic mice with adenocarcinoma of the prostate (TRAMP cells) were treated with the HMG-CoA reductase inhibitor,…”
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Pten dose dictates cancer progression in the prostate by Trotman, Lloyd C, Niki, Masaru, Dotan, Zohar A, Koutcher, Jason A, Di Cristofano, Antonio, Xiao, Andrew, Khoo, Alan S, Roy-Burman, Pradip, Greenberg, Norman M, Van Dyke, Terry, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo

“…Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, including prostate cancer (CaP). However, one PTEN allele is…”
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Characterization of the FGF axis and identification of a novel FGFR1iiic isoform during prostate cancer progression in the TRAMP model by Foster, B A, Kaplan, P J, Greenberg, N M

“…Expression of the fibroblast growth factor (FGF) axis was examined during prostate cancer progression in the autochthonous Transgenic Adenocarcinoma of Mouse…”
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Androgens and growth factors in prostate cancer: a transgenic perspective by Greenberg, N M

“…With the advent of transgenic technology, novel animal models are being developed to facilitate prostate cancer research. The ability to perform genetic…”
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Patterns of protease production during prostate cancer progression: proteomic evidence for cascades in a transgenic model by Bok, R A, Hansell, E J, Nguyen, T P, Greenberg, N M, McKerrow, J H, Shuman, M A

“…Extracellular proteases are recognized as critical factors in the progression of a number of carcinomas, including prostate cancer. Matrix metalloproteases…”
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