Search Results - "Greenbaum, C"

Latent autoimmune diabetes in adults (LADA) should be less latent by FOURLANOS, S, DOTTA, F, GREENBAUM, C. J, PALMER, J. P, ROLANDSSON, O, COLMAN, P. G, HARRISON, L. C

“…'Latent autoimmune diabetes in adults' (LADA) is the term coined to describe adults who have a slowly progressive form of autoimmune or type 1 diabetes that…”
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Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis by Joyce, Johanna A, Baruch, Amos, Chehade, Kareem, Meyer-Morse, Nicole, Giraudo, Enrico, Tsai, Fong-Ying, Greenbaum, Doron C, Hager, Jeffrey H, Bogyo, Matthew, Hanahan, Douglas

“…Tumors develop through successive stages characterized by changes in gene expression and protein function. Gene expression profiling of pancreatic islet tumors…”
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Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally Unique Specificities by Choe, Youngchool, Leonetti, Francesco, Greenbaum, Doron C., Lecaille, Fabien, Bogyo, Matthew, Brömme, Dieter, Ellman, Jonathan A., Craik, Charles S.

“…The substrate specificities of papain-like cysteine proteases (clan CA, family C1) papain, bromelain, and human cathepsins L, V, K, S, F, B, and five proteases…”
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NETosis‐associated serum biomarkers are reduced in type 1 diabetes in association with neutrophil count by Qin, J., Fu, S., Speake, C., Greenbaum, C. J., Odegard, J. M.

“…Summary As the immune pathways involved in the pathogenesis of type 1 diabetes (T1D) are not fully understood, biomarkers implicating novel mechanisms of…”
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Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases by Harbut, Michael B, Velmourougane, Geetha, Dalal, Seema, Reiss, Gilana, Whisstock, James C, Onder, Ozlem, Brisson, Dustin, McGowan, Sheena, Klemba, Michael, Greenbaum, Doron C

“…Malaria causes worldwide morbidity and mortality, and while chemotherapy remains an excellent means of malaria control, drug-resistant parasites necessitate…”
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The Trypanosoma cruzi protease cruzain mediates immune evasion by Doyle, Patricia S, Zhou, Yuan M, Hsieh, Ivy, Greenbaum, Doron C, McKerrow, James H, Engel, Juan C

“…Trypanosoma cruzi is the causative agent of Chagas' disease. Novel chemotherapy with the drug K11777 targets the major cysteine protease cruzain and disrupts…”
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Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design by Harbut, Michael B., Patel, Bhumit A., Yeung, Bryan K. S., McNamara, Case W., Bright, A. Taylor, Ballard, Jaime, Supek, Frantisek, Golde, Todd E., Winzeler, Elizabeth A., Diagana, Thierry T., Greenbaum, Doron C.

“…Early secretory and endoplasmic reticulum (ER)-localized proteins that are terminally misfolded or misassembled are degraded by a ubiquitin- and…”
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In‐vivo assessment of T cell kinetics in individuals at risk for type 1 diabetes by Hao, W., Bahnson, H. T., Speake, C., Cerosaletti, K., Greenbaum, C. J.

“…Summary We previously assessed the kinetics of T cell turnover in vivo by labeling cells with 2H‐H2O over 42 days in individuals with type 1 diabetes (T1D) and…”
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Mother-Infant Affect Synchrony as an Antecedent of the Emergence of Self-Control by Feldman, Ruth, Greenbaum, Charles W, Yirmiya, Nurit

“…This study examined relations between mother-infant affect synchrony and the emergence of children's self-control. Mother-infant face-to-face play and infant…”
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Platelet Factor 4 Activity against P. falciparum and Its Translation to Nonpeptidic Mimics as Antimalarials by Love, Melissa S., Millholland, Melanie G., Mishra, Satish, Kulkarni, Swapnil, Freeman, Katie B., Pan, Wenxi, Kavash, Robert W., Costanzo, Michael J., Jo, Hyunil, Daly, Thomas M., Williams, Dewight R., Kowalska, M. Anna, Bergman, Lawrence W., Poncz, Mortimer, DeGrado, William F., Sinnis, Photini, Scott, Richard W., Greenbaum, Doron C.

“…Plasmodium falciparum pathogenesis is affected by various cell types in the blood, including platelets, which can kill intraerythrocytic malaria parasites…”
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Dissecting heterogeneity in paediatric Type 1 diabetes: association of TCF7L2 rs7903146 TT and low‐risk human leukocyte antigen (HLA) genotypes by Redondo, M. J., Grant, S. F. A., Davis, A., Greenbaum, C.

“…Aims To test the hypothesis that non‐obese individuals with childhood‐onset Type 1 diabetes and the rs7903146 TT genotype would be less likely to have…”
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A Role for the Protease Falcipain 1 in Host Cell Invasion by the Human Malaria Parasite by Greenbaum, Doron C., Baruch, Amos, Grainger, Munira, Bozdech, Zbynek, Medzihradszky, Katlin F., Engel, Juan, DeRisi, Joseph, Holder, Anthony A., Bogyo, Matthew

“…Cysteine proteases of Plasmodium falciparum are required for survival of the malaria parasite, yet their specific cellular functions remain unclear. We used a…”
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Synthesis and Structure−Activity Relationships of Parasiticidal Thiosemicarbazone Cysteine Protease Inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi by Greenbaum, Doron C, Mackey, Zachary, Hansell, Elizabeth, Doyle, Patricia, Gut, Jiri, Caffrey, Conor R, Lehrman, Julia, Rosenthal, Philip J, McKerrow, James H, Chibale, Kelly

“…We have synthesized a library of thiosemicarbazones and screened them against three parasitic cysteine proteases, cruzain, falcipain-2, and rhodesain, and…”
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Metacognitive Regulation in Organic Chemistry Students: How and Why Students Use Metacognitive Strategies When Predicting Reactivity by Blackford, Katherine A, Greenbaum, Julia C, Redkar, Nikita S, Gaillard, Nelson T, Helix, Max R, Baranger, Anne M

“…Problem solving is a key component of authentic scientific research and practice in organic chemistry. One factor that has been shown to have a major role in…”
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Clinical evolution of beta cell function in youth with diabetes: the SEARCH for Diabetes in Youth study by Dabelea, D., Mayer-Davis, E. J., Andrews, J. S., Dolan, L. M., Pihoker, C., Hamman, R. F., Greenbaum, C., Marcovina, S., Fujimoto, W., Linder, B., Imperatore, G., D’Agostino, R.

“…Aims/hypothesis Few studies have explored the epidemiology of beta cell loss in youth with diabetes. This report describes the evolution and major determinants…”
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Distinct Protein Classes Including Novel Merozoite Surface Antigens in Raft-like Membranes of Plasmodium falciparum by Sanders, Paul R., Gilson, Paul R., Cantin, Greg T., Greenbaum, Doron C., Nebl, Thomas, Carucci, Daniel J., McConville, Malcolm J., Schofield, Louis, Hodder, Anthony N., Yates, John R., Crabb, Brendan S.

“…Glycosylphosphatidylinositol (GPI)-anchored proteins coat the surface of extracellular Plasmodium falciparum merozoites, of which several are highly validated…”
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Longitudinal monitoring of gene expression in ultra‐low‐volume blood samples self‐collected at home by Speake, C., Whalen, E., Gersuk, V. H., Chaussabel, D., Odegard, J. M., Greenbaum, C. J.

“…Summary Blood transcriptional profiles could serve as biomarkers of clinical changes in subjects at‐risk for or diagnosed with diabetes. However,…”
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Effects of Insulin in Relatives of Patients with Type 1 Diabetes Mellitus

“…Persons who are at high risk for type 1 diabetes may be identified on the basis of islet-cell antibody levels, insulin antibody levels, and genetic studies…”
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A Cathepsin B-like Protease Is Required for Host Protein Degradation in Trypanosoma brucei by Mackey, Zachary B, O'Brien, Theresa C, Greenbaum, Doron C, Blank, Rebecca B, McKerrow, James H

“…Identification and analysis of Clan CA (papain) cysteine proteases in primitive protozoa and metazoa have suggested that this enzyme family is more diverse and…”
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A Host GPCR Signaling Network Required for the Cytolysis of Infected Cells Facilitates Release of Apicomplexan Parasites by Millholland, Melanie G., Mishra, Satish, Dupont, Christopher D., Love, Melissa S., Patel, Bhumit, Shilling, Dustin, Kazanietz, Marcelo G., Foskett, J. Kevin, Hunter, Christopher A., Sinnis, Photini, Greenbaum, Doron C.

“…Following intracellular replication, the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii cause host cell cytolysis to facilitate parasite…”
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