The discovery of Arylex™ active and Rinskor™ active: Two novel auxin herbicides

[Display omitted] Multiple classes of commercially important auxin herbicides have been discovered since the 1940s including the aryloxyacetates (2,4-D, MCPA, dichlorprop, mecoprop, triclopyr, and fluroxypyr), the benzoates (dicamba), the quinoline-2-carboxylates (quinclorac and quinmerac), the pyri...

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Published in:	Bioorganic & medicinal chemistry Vol. 24; no. 3; pp. 362 - 371
Main Authors:	Epp, Jeffrey B., Alexander, Anita L., Balko, Terry W., Buysse, Ann M., Brewster, William K., Bryan, Kristy, Daeuble, John F., Fields, Stephen C., Gast, Roger E., Green, Renard A., Irvine, Nicholas M., Lo, William C., Lowe, Christian T., Renga, James M., Richburg, John S., Ruiz, James M., Satchivi, Norbert M., Schmitzer, Paul R., Siddall, Thomas L., Webster, Jeffery D., Weimer, Monte R., Whiteker, Gregory T., Yerkes, Carla N.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-02-2016
Subjects:	6-Aryl-picolinate Arylex Drug Discovery Edible Grain - drug effects Halauxifen Halauxifen-methyl Herbicides - chemical synthesis Herbicides - chemistry Herbicides - pharmacology Indoleacetic Acids - chemical synthesis Indoleacetic Acids - chemistry Indoleacetic Acids - pharmacology Oryza - drug effects Picloram - analogs & derivatives Picloram - chemical synthesis Picloram - chemistry Picloram - pharmacology Picolinate Rinskor Structure-Activity Relationship Halauxifen-methyl Halauxifen Picolinate Arylex Rinskor 6-Aryl-picolinate
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Summary:	[Display omitted] Multiple classes of commercially important auxin herbicides have been discovered since the 1940s including the aryloxyacetates (2,4-D, MCPA, dichlorprop, mecoprop, triclopyr, and fluroxypyr), the benzoates (dicamba), the quinoline-2-carboxylates (quinclorac and quinmerac), the pyrimidine-4-carboxylates (aminocyclopyrachlor), and the pyridine-2-carboxylates (picloram, clopyralid, and aminopyralid). In the last 10 years, two novel pyridine-2-carboxylate (or picolinate) herbicides were discovered at Dow AgroSciences. This paper will describe the structure activity relationship study that led to the discovery of the 6-aryl-picolinate herbicides Arylex™ active (2005) and Rinskor™ active (2010). While Arylex was developed primarily for use in cereal crops and Rinskor is still in development primarily for use in rice crops, both herbicides will also be utilized in additional crops.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0968-0896 1464-3391
DOI:	10.1016/j.bmc.2015.08.011