Search Results - "Green, Nicola H."
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Dinuclear Ruthenium(II) Complexes as Two-Photon, Time-Resolved Emission Microscopy Probes for Cellular DNA
Published in Angewandte Chemie International Edition (24-03-2014)“…The first transition‐metal complex‐based two‐photon absorbing luminescence lifetime probes for cellular DNA are presented. This allows cell imaging of DNA free…”
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Characterisation of the physical composition and microbial community structure of biofilms within a model full-scale drinking water distribution system
Published in PloS one (23-02-2015)“…Within drinking water distribution systems (DWDS), microorganisms form multi-species biofilms on internal pipe surfaces. A matrix of extracellular polymeric…”
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Oxygen Mapping of Melanoma Spheroids using Small Molecule Platinum Probe and Phosphorescence Lifetime Imaging Microscopy
Published in Scientific reports (06-09-2017)“…Solid tumours display varied oxygen levels and this characteristic can be exploited to develop new diagnostic tools to determine and exploit these variations…”
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4
A new mode of contrast in biological second harmonic generation microscopy
Published in Scientific reports (17-10-2017)“…Enhanced image contrast in biological second harmonic imaging microscopy (SHIM) has previously been reported via quantitative assessments of forward- to…”
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Second Harmonic Generation microscopy reveals collagen fibres are more organised in the cervix of postmenopausal women
Published in Reproductive biology and endocrinology (21-10-2016)“…During labour, the cervix undergoes a series of changes to allow the passage of the fetoplacental unit. While this visible transformation is well-described,…”
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Developing Repair Materials for Stress Urinary Incontinence to Withstand Dynamic Distension
Published in PloS one (16-03-2016)“…Polypropylene mesh used as a mid-urethral sling is associated with severe clinical complications in a significant minority of patients. Current in vitro…”
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Electrospun Fiber Alignment Guides Osteogenesis and Matrix Organization Differentially in Two Different Osteogenic Cell Types
Published in Frontiers in bioengineering and biotechnology (25-10-2021)“…Biomimetic replication of the structural anisotropy of musculoskeletal tissues is important to restore proper tissue mechanics and function. Physical cues from…”
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Surfactant-free gelatin-stabilised biodegradable polymerised high internal phase emulsions with macroporous structures
Published in Frontiers in chemistry (23-08-2023)“…High internal phase emulsion (HIPE) templating is a well-established method for the generation of polymeric materials with high porosity (>74%) and degree of…”
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Monitoring fibrous scaffold guidance of three-dimensional collagen organisation using minimally-invasive second harmonic generation
Published in PloS one (28-02-2014)“…The biological and mechanical function of connective tissues is largely determined by controlled cellular alignment and therefore it seems appropriate that…”
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Development of PCL PolyHIPE Substrates for 3D Breast Cancer Cell Culture
Published in Bioengineering (Basel) (26-04-2023)“…Cancer is a becoming a huge social and economic burden on society, becoming one of the most significant barriers to life expectancy in the 21st century. In…”
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Porous microspheres support mesenchymal progenitor cell ingrowth and stimulate angiogenesis
Published in APL bioengineering (01-06-2018)“…Porous microspheres have the potential for use as injectable bone fillers to obviate the need for open surgery. Successful bone fillers must be able to support…”
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Gelatin-containing porous polycaprolactone PolyHIPEs as substrates for 3D breast cancer cell culture and vascular infiltration
Published in Frontiers in bioengineering and biotechnology (08-01-2024)“…Tumour survival and growth are reliant on angiogenesis, the formation of new blood vessels, to facilitate nutrient and waste exchange and, importantly, provide…”
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Production and Characterization of a Novel, Electrospun, Tri-Layer Polycaprolactone Membrane for the Segregated Co-Culture of Bone and Soft Tissue
Published in Polymers (07-06-2016)“…Composite tissue-engineered constructs combining bone and soft tissue have applications in regenerative medicine, particularly dentistry. This study generated…”
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Emulsion templated scaffolds with tunable mechanical properties for bone tissue engineering
Published in Journal of the mechanical behavior of biomedical materials (01-02-2016)“…Polymerised High Internal Phase Emulsions (PolyHIPEs) are manufactured via emulsion templating and exhibit a highly interconnected microporosity. These…”
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The use of microphysiological systems to model metastatic cancer
Published in Biofabrication (01-07-2024)“…Cancer is one of the leading causes of death in the 21st century, with metastasis of cancer attributing to 90% of cancer-related deaths. Therefore, to improve…”
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Porous biomaterials for tissue engineering: a review
Published in Journal of materials chemistry. B, Materials for biology and medicine (19-10-2022)“…The field of biomaterials has grown rapidly over the past decades. Within this field, porous biomaterials have played a remarkable role in: (i) enabling the…”
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In Vitro Low-Fluence Photodynamic Therapy Parameter Screening Using 3D Tumor Spheroids Shows that Fractionated Light Treatments Enhance Phototoxicity
Published in ACS biomaterials science & engineering (08-11-2021)“…The evaluation of novel photosensitizers (PSs) for photodynamic therapy (PDT) is difficult due to the limitations of two-dimensional cell culture and multiple…”
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Raman spectroscopy detects melanoma and the tissue surrounding melanoma using tissue-engineered melanoma models
Published in Applied spectroscopy reviews (20-04-2016)“…Invasion of melanoma cells from the primary tumor involves interaction with adjacent tissues and extracellular matrix. The extent of this interaction is not…”
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Poly(n-butyl methacrylate) with primary amine end groups for supporting cell adhesion and proliferation of renal epithelial cells
Published in International journal of polymeric materials (13-10-2017)“…Polymer coatings that support epithelial cell culture have been developed. Ozonolysis and subsequent workup of poly(butyl methacrylate-co-butadiene) copolymers…”
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Creating a model of diseased artery damage and failure from healthy porcine aorta
Published in Journal of the mechanical behavior of biomedical materials (01-07-2016)“…Large quantities of diseased tissue are required in the research and development of new generations of medical devices, for example for use in physical…”
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