Synthetic Strategy Towards Heterodimetallic Half-Sandwich Complexes Based on a Symmetric Ditopic Ligand

Synthetic Strategy Towards Heterodimetallic Half-Sandwich Complexes Based on a Symmetric Ditopic Ligand

Multimetallic complexes have been shown in several examples to possess greater anticancer activity than their monometallic counterparts. The increased activity has been attributed to altered modes of action. We herein report the synthesis of a series of heterodimetallic compounds based on a ditopic...

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Bibliographic Details
Published in:Frontiers in chemistry Vol. 9; p. 786367
Main Authors: Green, Lewis P M, Steel, Tasha R, Riisom, Mie, Hanif, Muhammad, Söhnel, Tilo, Jamieson, Stephen M F, Wright, L James, Crowley, James D, Hartinger, Christian G
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 03-12-2021
Subjects:
anticancer activity
bioorganometallics
Chemistry
heterodimetallic complexes
ligand exchange reactions
structural characterization
bioorganometallics
anticancer activity
ligand exchange reactions
structural characterization
heterodimetallic complexes
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Summary:Multimetallic complexes have been shown in several examples to possess greater anticancer activity than their monometallic counterparts. The increased activity has been attributed to altered modes of action. We herein report the synthesis of a series of heterodimetallic compounds based on a ditopic ligand featuring 2-pyridylimine chelating motifs and organometallic half-sandwich moieties. The complexes were characterized by a combination of H NMR spectroscopy, electrospray ionization mass spectrometry, elemental analysis and single crystal X-ray diffraction. Investigations into the stability of representative complexes in DMSO- and 10% DMSO- /D O revealed the occurrence of solvent-chlorido ligand exchange. Proliferation assays in four human cancer cell lines showed that the Os-Rh complex possessed minimal activity, while all other complexes were inactive.
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Roberto Santana Da Silva, University of São Paulo, Brazil
Reviewed by: Alzir Azevedo Batista, Federal University of São Carlos, Brazil
This article was submitted to Medicinal and Pharmaceutical Chemistry, a section of the journal Frontiers in Chemistry
Edited by: Dinorah Gambino, Universidad de la República, Uruguay
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2021.786367