Search Results - "Green, Jennie R"
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Fmr1 and Nlgn3 Knockout Rats: Novel Tools for Investigating Autism Spectrum Disorders
Published in Behavioral neuroscience (01-04-2014)“…Animal models are critical for gaining insights into autism spectrum disorder (ASD). Despite their apparent advantages to mice for neural studies, rats have…”
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Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome
Published in Human molecular genetics (01-08-2016)“…Mouse models of the transcriptional modulator Methyl-CpG-Binding Protein 2 (MeCP2) have advanced our understanding of Rett syndrome (RTT). RTT is a…”
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Onset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability
Published in PloS one (07-12-2011)“…In the present study we report on the use of speed congenics to generate a C57BL/6J congenic line of HD-model R6/2 mice carrying 110 CAG repeats, which…”
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Soft windowing application to improve analysis of high-throughput phenotyping data
Published in Bioinformatics (01-03-2020)“…Abstract Motivation High-throughput phenomic projects generate complex data from small treatment and large control groups that increase the power of the…”
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Genetic background modulates behavioral impairments in R6/2 mice and suggests a role for dominant genetic modifiers in Huntington’s disease pathogenesis
Published in Mammalian genome (01-06-2012)“…Variability and modification of the symptoms of Huntington’s disease (HD) are commonly observed in both patient populations and animal models of the disease…”
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New models for human disease from the International Mouse Phenotyping Consortium
Published in Mammalian genome (01-06-2019)“…The International Mouse Phenotyping Consortium (IMPC) continues to expand the catalogue of mammalian gene function by conducting genome and phenome-wide…”
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