Search Results - "Green, Jeffrey E."

Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence by Vera-Ramirez, Laura, Vodnala, Suman K., Nini, Ryan, Hunter, Kent W., Green, Jeffrey E.

“…Cancer recurrence after initial diagnosis and treatment is a major cause of breast cancer (BC) mortality, which results from the metastatic outbreak of dormant…”
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Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients by Szász, A Marcell, Lánczky, András, Nagy, Ádám, Förster, Susann, Hark, Kim, Green, Jeffrey E, Boussioutas, Alex, Busuttil, Rita, Szabó, András, Győrffy, Balázs

“…Multiple gene expression based prognostic biomarkers have been repeatedly identified in gastric carcinoma. However, without confirmation in an independent…”
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Extracellular matrix: A gatekeeper in the transition from dormancy to metastatic growth by Barkan, Dalit, Green, Jeffrey E, Chambers, Ann F

“…Abstract Metastases can develop after apparently successful treatment of a primary tumour, sometimes following a period of tumour dormancy that can last for…”
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Metastatic Growth from Dormant Cells Induced by a Col-I―Enriched Fibrotic Environment by BARKAN, Dalit, EL TOUNY, Lara H, GREEN, Jeffrey E, MICHALOWSKI, Aleksandra M, SMITH, Jane Ann, CHU, Isabel, SALLY DAVIS, Anne, WEBSTER, Joshua D, HOOVER, Shelley, SIMPSON, R. Mark, GAULDIE, Jack

“…Breast cancer that recurs as metastatic disease many years after primary tumor resection and adjuvant therapy seems to arise from tumor cells that disseminated…”
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Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells by El Touny, Lara H, Vieira, Anthony, Mendoza, Arnulfo, Khanna, Chand, Hoenerhoff, Mark J, Green, Jeffrey E

“…Breast cancer (BC) can recur as metastatic disease many years after primary tumor removal, suggesting that disseminated tumor cells survive for extended…”
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A Phase II Single Arm Pilot Study of the CHK1 Inhibitor Prexasertib (LY2606368) in BRCA Wild‐Type, Advanced Triple‐Negative Breast Cancer by Gatti‐Mays, Margaret E., Karzai, Fatima H., Soltani, Sanaz N., Zimmer, Alexandra, Green, Jeffrey E., Lee, Min‐Jung, Trepel, Jane B., Yuno, Akira, Lipkowitz, Stanley, Nair, Jayakumar, McCoy, Ann, Lee, Jung‐Min

“…Lessons Learned Monotherapy with prexasertib demonstrated modest activity in BRCA wild‐type, recurrent triple‐negative breast cancer, highlighting the unmet…”
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Identification of tumor-initiating cells in a p53-null mouse model of breast cancer by Zhang, Mei, Behbod, Fariba, Atkinson, Rachel L, Landis, Melissa D, Kittrell, Frances, Edwards, David, Medina, Daniel, Tsimelzon, Anna, Hilsenbeck, Susan, Green, Jeffrey E, Michalowska, Aleksandra M, Rosen, Jeffrey M

“…Using a syngeneic p53-null mouse mammary gland tumor model that closely mimics human breast cancer, we have identified, by limiting dilution transplantation…”
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Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton by Barkan, Dalit, Kleinman, Hynda, Simmons, Justin L, Asmussen, Holly, Kamaraju, Anil K, Hoenorhoff, Mark J, Liu, Zi-yao, Costes, Sylvain V, Cho, Edward H, Lockett, Stephen, Khanna, Chand, Chambers, Ann F, Green, Jeffrey E

“…Metastatic breast cancer may emerge from latent tumor cells that remain dormant at disseminated sites for many years. Identifying mechanisms regulating the…”
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A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients by Kim, Hark Kyun, Choi, Il Ju, Kim, Chan Gyoo, Kim, Hee Sung, Oshima, Akira, Michalowski, Aleksandra, Green, Jeffrey E

“…We initiated a prospective trial to identify transcriptional alterations associated with acquired chemotherapy resistance from pre- and post-biopsy samples…”
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Loss of function Cbl-c mutations in solid tumors by Daniels, Silvano Rakeem, Liyasova, Mariya, Kales, Stephen C, Nau, Marion M, Ryan, Philip E, Green, Jeffrey E, Lipkowitz, Stanley

“…Receptor Tyrosine Kinase (RTK) signaling is essential for normal biological processes and disruption of this regulation can lead to tumor initiation and…”
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Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis by Park, Jun Won, Jang, Seok Hoon, Park, Dong Min, Lim, Na Jung, Deng, Chuxia, Kim, Dae Yong, Green, Jeffrey E, Kim, Hark Kyun

“…Loss of E-cadherin (CDH1), Smad4, and p53 has been shown to play an integral role in gastric, intestinal, and breast cancer formation. Compound conditional…”
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MicroRNA regulation in cancer-associated fibroblasts by Aprelikova, Olga, Green, Jeffrey E.

“…The microenvironment of cancer cells has proven to be a critical component of tumors that strongly influences cancer development and progression into invasive…”
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miRNA signature associated with outcome of gastric cancer patients following chemotherapy by Kim, Chang Hee, Kim, Hark K, Rettig, R Luke, Kim, Joseph, Lee, Eunbyul T, Aprelikova, Olga, Choi, Il J, Munroe, David J, Green, Jeffrey E

“…Identification of patients who likely will or will not benefit from cytotoxic chemotherapy through the use of biomarkers could greatly improve clinical…”
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Inhibition of prostate cancer growth by muscadine grape skin extract and resveratrol through distinct mechanisms by HUDSON, Tamaro S, HARTLE, Diane K, HURSTING, Stephen D, NUNEZ, Nomeli P, WANG, Thomas T. Y, YOUNG, Heather A, ARANY, Praveen, GREEN, Jeffrey E

“…The phytochemical resveratrol contained in red grapes has been shown to inhibit prostate cancer cell growth, in part, through its antioxidant activity…”
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Striking efficacy of a vaccine targeting TOP2A for triple-negative breast cancer immunoprevention by Lee, Sang Beom, Pan, Jing, Xiong, Donghai, Palen, Katie, Johnson, Bryon, Lubet, Ronald A., Shoemaker, Robert H., Green, Jeffrey E., Fernando, Romaine Ingrid, Sei, Shizuko, You, Ming, Wang, Yian

“…Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that has a poor prognosis. TOP2A is a key enzyme in DNA replication and is a…”
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Expression of GATA3 in MDA-MB-231 triple-negative breast cancer cells induces a growth inhibitory response to TGFß by Chu, Isabel M, Lai, Wei-Chu, Aprelikova, Olga, El Touny, Lara H, Kouros-Mehr, Hosein, Green, Jeffrey E

“…Transforming growth factor (ß1TGFß1) can promote proliferation in late stage cancers but acts as a tumor suppressor in normal epithelial cells and in early…”
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Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases by Aprelikova, Olga, Tomlinson, Christine C, Hoenerhoff, Mark, Hixon, Julie A, Durum, Scott K, Qiu, Ting-Hu, He, Siping, Burkett, Sandra, Liu, Zi-Yao, Swanson, Steven M, Green, Jeffrey E

“…Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is associated with a poor prognosis and for which no targeted therapies…”
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Lack of effect of metformin on mammary carcinogenesis in nondiabetic rat and mouse models by Thompson, Matthew D, Grubbs, Clinton J, Bode, Ann M, Reid, Joel M, McGovern, Renee, Bernard, Philip S, Stijleman, Inge J, Green, Jeffrey E, Bennett, Christina, Juliana, M Margaret, Moeinpour, Fariba, Steele, Vernon E, Lubet, Ronald A

“…Epidemiologic studies have shown that diabetics receiving the biguanide metformin, as compared with sulfonylureas or insulin, have a lower incidence of breast…”
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Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified Wybutosine (yW) base in phenylalanine-tRNA by Rodriguez, Virginia, Vasudevan, Sona, Noma, Akiko, Carlson, Bradley A, Green, Jeffrey E, Suzuki, Tsutomu, Chandrasekharappa, Settara C

“…Posttranscriptional modifications are critical for structure and function of tRNAs. Wybutosine (yW) and its derivatives are hyper-modified guanosines found at…”
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The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting by Cardiff, R D, Anver, M R, Gusterson, B A, Hennighausen, L, Jensen, R A, Merino, M J, Rehm, S, Russo, J, Tavassoli, F A, Wakefield, L M, Ward, J M, Green, J E

“…NIH sponsored a meeting of medical and veterinary pathologists with mammary gland expertise in Annapolis in March 1999. Rapid development of mouse mammary…”
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