Search Results - "Green, Edward W."

The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease by Campesan, Susanna, Green, Edward W., Breda, Carlo, Sathyasaikumar, Korrapati V., Muchowski, Paul J., Schwarcz, Robert, Kyriacou, Charalambos P., Giorgini, Flaviano

“…Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have been implicated in the pathophysiology of neurodegenerative disorders,…”
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Dissociation of Circadian and Circatidal Timekeeping in the Marine Crustacean Eurydice pulchra by Zhang, Lin, Hastings, Michael H., Green, Edward W., Tauber, Eran, Sladek, Martin, Webster, Simon G., Kyriacou, Charalambos P., Wilcockson, David C.

“…Tidal (12.4 hr) cycles of behavior and physiology adapt intertidal organisms to temporally complex coastal environments, yet their underlying mechanism is…”
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An electromagnetic field disrupts negative geotaxis in Drosophila via a CRY-dependent pathway by Fedele, Giorgio, Green, Edward W., Rosato, Ezio, Kyriacou, Charalambos P.

“…Many higher animals have evolved the ability to use the Earth’s magnetic field, particularly for orientation. Drosophila melanogaster also respond to…”
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A Drosophila RNAi collection is subject to dominant phenotypic effects by Green, Edward W, Fedele, Giorgio, Giorgini, Flaviano, Kyriacou, Charalambos P

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Characterising cancer-associated fibroblast heterogeneity in non-small cell lung cancer: a systematic review and meta-analysis by Irvine, Andrew F., Waise, Sara, Green, Edward W., Stuart, Beth, Thomas, Gareth J.

“…Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with evidence suggesting they represent a heterogeneous population…”
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Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites by Breda, Carlo, Sathyasaikumar, Korrapati V., Idrissi, Shama Sograte, Notarangelo, Francesca M., Estranero, Jasper G., Moore, Gareth G. L., Green, Edward W., Kyriacou, Charalambos P., Schwarcz, Robert, Giorgini, Flaviano

“…Metabolites of the kynurenine pathway (KP) of tryptophan (TRP) degradation have been closely linked to the pathogenesis of several neurodegenerative disorders…”
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Glutathione peroxidase activity is neuroprotective in models of Huntington's disease by Mason, Robert P, Casu, Massimiliano, Butler, Nicola, Breda, Carlo, Campesan, Susanna, Clapp, Jannine, Green, Edward W, Dhulkhed, Devyani, Kyriacou, Charalambos P, Giorgini, Flaviano

“…Flaviano Giorgini and colleagues perform an overexpression screen in yeast to identify genes that can suppress the toxic effects of the mutant Huntington's…”
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Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease by Aron, Rebecca, Pellegrini, Pasquale, Green, Edward W., Maddison, Daniel C., Opoku-Nsiah, Kwadwo, Oliveira, Ana Osório, Wong, Jinny S., Daub, Aaron C., Giorgini, Flaviano, Muchowski, Paul, Finkbeiner, Steven

“…Huntington’s disease is a progressive neurodegenerative disorder caused by polyglutamine-expanded mutant huntingtin (mHTT). Here, we show that the…”
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Correction: The circadian clock gene bmal1 is necessary for co-ordinated circatidal rhythms in the marine isopod Eurydice pulchra (Leach) by Zhang, Lin, Green, Edward W, Webster, Simon G, Hastings, Michael H, Wilcockson, David C, Kyriacou, Charalambos P

“…[This corrects the article DOI: 10.1371/journal.pgen.1011011.]…”
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The circadian clock gene bmal1 is necessary for co-ordinated circatidal rhythms in the marine isopod Eurydice pulchra (Leach) by Lin, Zhang, Green, Edward W, Webster, Simon G, Hastings, Michael H, Wilcockson, David C, Kyriacou, Charalambos P

“…Circadian clocks in terrestrial animals are encoded by molecular feedback loops involving the negative regulators PERIOD, TIMELESS or CRYPTOCHROME2 and…”
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Genetic analysis of circadian responses to low frequency electromagnetic fields in Drosophila melanogaster by Fedele, Giorgio, Edwards, Mathew D, Bhutani, Supriya, Hares, John M, Murbach, Manuel, Green, Edward W, Dissel, Stephane, Hastings, Michael H, Rosato, Ezio, Kyriacou, Charalambos P

“…The blue-light sensitive photoreceptor cryptochrome (CRY) may act as a magneto-receptor through formation of radical pairs involving a triad of tryptophans…”
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A non-linear optimisation method to extract summary statistics from Kaplan-Meier survival plots using the published P value by Irvine, Andrew F, Waise, Sara, Green, Edward W, Stuart, Beth

“…Meta-analyses of studies evaluating survival (time-to-event) outcomes are a powerful technique to assess the strength of evidence for a given disease or…”
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Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBPβ by Kudo, Takumi, Prentzell, Mirja T, Mohapatra, Soumya R, Sahm, Felix, Zhao, Zhongliang, Grummt, Ingrid, Wick, Wolfgang, Opitz, Christiane A, Platten, Michael, Green, Edward W

“…Catabolism of the essential amino acid tryptophan is a key metabolic pathway contributing to the immunosuppressive tumor microenvironment and therefore a…”
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Drosophila circadian rhythms in seminatural environments: Summer afternoon component is not an artifact and requires TrpA1 channels by Green, Edward W, Emma K. O’Callaghan, Celia N. Hansen, Stefano Bastianello, Supriya Bhutani, Stefano Vanin, James Douglas Armstrong, Rodolfo Costa, Charalambos P. Kyriacou

“…Under standard laboratory conditions of rectangular light/dark cycles and constant warm temperature, Drosophila melanogaster show bursts of morning (M) and…”
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Common T-Cell-Receptor Motifs and Features in Patients with Cytomegalovirus (CMV)-Seronegative End-Stage Renal Disease Receiving a Peptide Vaccination against CMV by Bunse, Lukas, Sommerer, Claudia, Tan, Chin Leng, Korell, Felix, Schmitt, Anita, Hückelhoven-Krauss, Angela, Neuber, Brigitte, Mertens, Thomas, Platten, Michael, Green, Edward W, Zeier, Martin, Schmitt, Michael

“…After solid-organ transplantation, reactivation of the cytomegalovirus (CMV) is often observed in seronegative patients and associated with a high risk of…”
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Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease by Aron, Rebecca, Pellegrini, Pasquale, Green, Edward W., Maddison, Daniel C., Opoku-Nsiah, Kwadwo, Oliveira, Ana Osório, Wong, Jinny S., Daub, Aaron C., Giorgini, Flaviano, Muchowski, Paul, Finkbeiner, Steven

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Choosing and using Drosophila models to characterize modifiers of Huntington's disease by Green, Edward W, Giorgini, Flaviano

“…HD (Huntington's disease) is a fatal inherited gain-of-function disorder caused by a polyQ (polyglutamine) expansion in the htt (huntingtin protein)…”
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Proteomic Analysis Reveals the Role of Synaptic Vesicle Cycling in Sustaining the Suprachiasmatic Circadian Clock by Deery, Michael J., Maywood, Elizabeth S., Chesham, Johanna E., Sládek, Martin, Karp, Natasha A., Green, Edward W., Charles, Philip D., Reddy, Akhilesh B., Kyriacou, Charalambos P., Lilley, Kathryn S., Hastings, Michael H.

“…The central circadian pacemaker of the suprachiasmatic nucleus (SCN) is characterized as a series of transcriptional/posttranslational feedback loops [1, 2]…”
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Author Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease by Aron, Rebecca, Pellegrini, Pasquale, Green, Edward W., Maddison, Daniel C., Opoku-Nsiah, Kwadwo, Osório Oliveira, Ana, Wong, Jinny S., Daub, Aaron C., Giorgini, Flaviano, Muchowski, Paul, Finkbeiner, Steven

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease by Aron, Rebecca, Pellegrini, Pasquale, Green, Edward W., Maddison, Daniel C., Opoku-Nsiah, Kwadwo, Wong, Jinny S., Daub, Aaron C., Giorgini, Flaviano, Finkbeiner, Steven

“…The original version of this Article incorrectly gave a publication date of 8 October 2018; this should have been 28 September 2018. This has now been…”
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