Search Results - "Green, Carla B."

Central and Peripheral Circadian Clocks in Mammals by MOHAWK, Jennifer A, GREEN, Carla B, TAKAHASHI, Joseph S

“…The circadian system of mammals is composed of a hierarchy of oscillators that function at the cellular, tissue, and systems levels. A common molecular…”
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Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice by Acosta-Rodríguez, Victoria, Rijo-Ferreira, Filipa, Izumo, Mariko, Xu, Pin, Wight-Carter, Mary, Green, Carla B, Takahashi, Joseph S

“…Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain poorly understood. Under CR, mice self-impose chronic cycles of…”
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Importance of circadian timing for aging and longevity by Acosta-Rodríguez, Victoria A., Rijo-Ferreira, Filipa, Green, Carla B., Takahashi, Joseph S.

“…Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR can be achieved by controlling how much and/or when food is provided,…”
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Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm by Yoo, Seung-Hee, Mohawk, Jennifer A., Siepka, Sandra M., Shan, Yongli, Huh, Seong Kwon, Hong, Hee-Kyung, Kornblum, Izabela, Kumar, Vivek, Koike, Nobuya, Xu, Ming, Nussbaum, Justin, Liu, Xinran, Chen, Zheng, Chen, Zhijian J., Green, Carla B., Takahashi, Joseph S.

“…Period determination in the mammalian circadian clock involves the turnover rate of the repressors CRY and PER. We show that CRY ubiquitination engages two…”
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Time to target the circadian clock for drug discovery by Rasmussen, Emil Sjulstok, Takahashi, Joseph S., Green, Carla B.

“…The circadian clock is an intracellular timekeeping device that drives daily rhythms in diverse and extensive processes throughout the body. The clock…”
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Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles by Sinturel, Flore, Gerber, Alan, Mauvoisin, Daniel, Wang, Jingkui, Gatfield, David, Stubblefield, Jeremy J., Green, Carla B., Gachon, Frédéric, Schibler, Ueli

“…The liver plays a pivotal role in metabolism and xenobiotic detoxification, processes that must be particularly efficient when animals are active and feed. A…”
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TH17 Cell Differentiation Is Regulated by the Circadian Clock by Yu, Xiaofei, Rollins, Darcy, Ruhn, Kelly A., Stubblefield, Jeremy J., Green, Carla B., Kashiwada, Masaki, Rothman, Paul B., Takahashi, Joseph S., Hooper, Lora V.

“…Circadian clocks regulate numerous physiological processes that vary across the day-night (diurnal) cycle, but if and how the circadian clock regulates the…”
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Circadian control of mRNA polyadenylation dynamics regulates rhythmic protein expression by Kojima, Shihoko, Sher-Chen, Elaine L, Green, Carla B

“…Poly(A) tails are 3' modifications of eukaryotic mRNAs that are important in the control of translation and mRNA stability. We identified hundreds of mouse…”
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Post-transcriptional control of circadian rhythms by Kojima, Shihoko, Shingle, Danielle L, Green, Carla B

“…Circadian rhythms exist in most living organisms. The general molecular mechanisms that are used to generate 24-hour rhythms are conserved among organisms,…”
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Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon by Zoltowski, Brian D., Chelliah, Yogarany, Wickramaratne, Anushka, Jarocha, Lauren, Karki, Nischal, Xu, Wei, Mouritsen, Henrik, Hore, Peter J., Hibbs, Ryan E., Green, Carla B., Takahashi, Joseph S.

“…Computational and biochemical studies implicate the blue-light sensor cryptochrome (CRY) as an endogenous light-dependent magnetosensor enabling migratory…”
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Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge by Nohara, Kazunari, Mallampalli, Venkata, Nemkov, Travis, Wirianto, Marvin, Yang, Jiah, Ye, Youqiong, Sun, Yuxiang, Han, Leng, Esser, Karyn A., Mileykovskaya, Eugenia, D’Alessandro, Angelo, Green, Carla B., Takahashi, Joseph S., Dowhan, William, Yoo, Seung-Hee, Chen, Zheng

“…Circadian disruption aggravates age-related decline and mortality. However, it remains unclear whether circadian enhancement can retard aging in mammals. We…”
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Circadian Genomics Reveal a Role for Post-transcriptional Regulation in Mammals by Kojima, Shihoko, Green, Carla B

“…To maintain daily cycles, the circadian clock must tightly regulate the rhythms of thousands of mRNAs and proteins with the correct period, phase, and…”
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Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex by Huang, Nian, Chelliah, Yogarany, Shan, Yongli, Taylor, Clinton A., Yoo, Seung-Hee, Partch, Carrie, Green, Carla B., Zhang, Hong, Takahashi, Joseph S.

“…The circadian clock in mammals is driven by an autoregulatory transcriptional feedback mechanism that takes approximately 24 hours to complete. A key component…”
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An evolutionary hotspot defines functional differences between CRYPTOCHROMES by Rosensweig, Clark, Reynolds, Kimberly A., Gao, Peng, Laothamatas, Isara, Shan, Yongli, Ranganathan, Rama, Takahashi, Joseph S., Green, Carla B.

“…Mammalian circadian clocks are driven by a transcription/translation feedback loop composed of positive regulators (CLOCK/BMAL1) and repressors (CRYPTOCHROME…”
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Nocturnin Regulates Circadian Trafficking of Dietary Lipid in Intestinal Enterocytes by Douris, Nicholas, Kojima, Shihoko, Pan, Xiaoyue, Lerch-Gaggl, Alexandra F., Duong, Son Q., Hussain, M. Mahmood, Green, Carla B.

“…Efficient metabolic function in mammals depends on the circadian clock, which drives temporal regulation of metabolic processes. Nocturnin is a clock-regulated…”
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Temporal Control of Metabolic Amplitude by Nocturnin by Stubblefield, Jeremy J., Gao, Peng, Kilaru, Gokhul, Mukadam, Bilal, Terrien, Jeremy, Green, Carla B.

“…The timing of food intake and nutrient utilization is critical to health and regulated partly by the circadian clock. Increased amplitude of circadian…”
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MicroRNA-122 modulates the rhythmic expression profile of the circadian deadenylase Nocturnin in mouse liver by Kojima, Shihoko, Gatfield, David, Esau, Christine C, Green, Carla B

“…Nocturnin is a circadian clock-regulated deadenylase thought to control mRNA expression post-transcriptionally through poly(A) tail removal. The expression of…”
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Activity-dependent FUS dysregulation disrupts synaptic homeostasis by Sephton, Chantelle F., Tang, Amy A., Kulkarni, Ashwinikumar, West, James, Brooks, Mieu, Stubblefield, Jeremy J., Liu, Yun, Zhang, Michael Q., Green, Carla B., Huber, Kimberly M., Huang, Eric J., Herz, Joachim, Yu, Gang

“…The RNA-binding protein fused-in-sarcoma (FUS) has been associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two…”
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Misaligned feeding uncouples daily rhythms within brown adipose tissue and between peripheral clocks by Acosta-Rodríguez, Victoria A., Rijo-Ferreira, Filipa, van Rosmalen, Laura, Izumo, Mariko, Park, Noheon, Joseph, Chryshanthi, Hepler, Chelsea, Thorne, Anneke K., Stubblefield, Jeremy, Bass, Joseph, Green, Carla B., Takahashi, Joseph S.

“…Extended food consumption during the rest period perturbs the phase relationship between circadian clocks in the periphery and the brain, leading to adverse…”
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Nocturnin: at the crossroads of clocks and metabolism by Stubblefield, Jeremy J, Terrien, Jérémy, Green, Carla B

“…Many aspects of metabolism exhibit daily rhythmicity under the control of endogenous circadian clocks, and disruptions in circadian timing result in…”
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