Search Results - "Grechikhina, Maria V"
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Reduced Immunosenescence of Peripheral Blood T Cells in Parkinson's Disease with CMV Infection Background
Published in International journal of molecular sciences (04-12-2021)“…Immunosenescence is a process of remodeling the immune system under the influence of chronic inflammation during aging. Parkinson's disease (PD) is a common…”
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Increased Susceptibility of the CD57 - NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response
Published in International journal of molecular sciences (11-12-2021)“…Nowadays, the use of genetically modified NK cells is a promising strategy for cancer immunotherapy. The additional insertion of genes capable of inducing cell…”
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Recurrent Stimulation of Natural Killer Cell Clones with K562 Expressing Membrane-Bound Interleukin-21 Affects Their Phenotype, Interferon-γ Production, and Lifespan
Published in International journal of molecular sciences (21-01-2019)“…A pattern of natural killer cell (NK cell) heterogeneity determines proliferative and functional responses to activating stimuli in individuals. Obtaining the…”
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Three-Dimensional Model Analysis Revealed Differential Cytotoxic Effects of the NK-92 Cell Line and Primary NK Cells on Breast and Ovarian Carcinoma Cell Lines Mediated by Variations in Receptor-Ligand Interactions and Soluble Factor Profiles
Published in Biomedicines (20-10-2024)“…The functional activity of a certain tumor determines the effectiveness of primary NK cells and NK-92 cell line-based cancer therapy; their therapeutic…”
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Targeted Delivery of HSP70 to Tumor Cells via Supramolecular Complex Based on HER2-Specific DARPin9_29 and the Barnase:Barstar Pair
Published in Cells (Basel, Switzerland) (01-02-2024)“…(1) Background: We have previously shown that the use of an artificial supramolecular two-component system based on chimeric recombinant proteins…”
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Alterations in Proteostasis System Components in Peripheral Blood Mononuclear Cells in Parkinson Disease: Focusing on the HSP70 and p62 Levels
Published in Biomolecules (Basel, Switzerland) (24-03-2022)“…Parkinson disease (PD) is attributed to a proteostasis disorder mediated by α-synuclein accumulating in a specific brain region. PD manifestation is often…”
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HLA‐DR‐expressing NK cells: Effective killers suspected for antigen presentation
Published in Journal of leukocyte biology (01-02-2021)“…HLA‐DR‐expressing cells comprise an intriguing group of NK cells, which combine phenotypic characteristics of both NK cells and dendritic cells. These cells…”
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Therapeutic efficacy of antibody-drug conjugates targeting GD2-positive tumors
Published in Journal for immunotherapy of cancer (01-06-2022)“…BackgroundBoth ganglioside GD2-targeted immunotherapy and antibody-drug conjugates (ADCs) have demonstrated clinical success as solid tumor therapies in recent…”
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ROS production, intracellular HSP70 levels and their relationship in human neutrophils: effects of age
Published in Oncotarget (15-12-2014)“…ROS production and intracellular HSP70 levels were measured in human neutrophils for three age groups: young (20-59 years), elders (60-89 years) and…”
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