Responsiveness and Minimal Clinically Important Difference of the Infants and Toddlers Dermatology Quality of Life Questionnaire

Background The Infants and Toddlers Dermatology Quality of Life (InToDermQoL) is the dermatology-specific proxy health-related quality of life (HRQoL) instrument for children from birth to 4 years. The aim of the present study was to confirm the responsiveness and establish minimal clinically import...

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Published in:	Dermatology and therapy Vol. 13; no. 11; pp. 2879 - 2893
Main Authors:	Chernyshov, Pavel V., Marron, Servando E., Koumaki, Dimitra, Pustišek, Nives, Manolache, Liana, Salavastru, Carmen, Suru, Alina, Sendrea, Adelina, Svyatenko, Tetiana, Statkevych, Olha, Boffa, Michael J., Grech, Sara Borg, Zemskov, Sergii, Kuts, Volodymyr V., Lishchynskyi, Pavlo, Chernyshov, Andrii V., Tomas-Aragones, Lucia
Format:	Journal Article
Language:	English
Published:	Cheshire Springer Healthcare 01-11-2023 Springer Adis, Springer Healthcare
Subjects:	Behavior Brief Report Care and treatment Children Dermatology Health aspects Health surveys Infants Infants and Toddlers Dermatology Quality of Life Internal Medicine Medical colleges Medicine Medicine & Public Health Minimal clinically important difference Oral and Maxillofacial Surgery Pediatric research Plastic Surgery Quality of life Quality of Life Research Responsiveness Skin Skin diseases Surveys Toddlers Ukraine Taiwan Responsiveness Infants and Toddlers Dermatology Quality of Life Children Dermatology Minimal clinically important difference Quality of life
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Summary:	Background The Infants and Toddlers Dermatology Quality of Life (InToDermQoL) is the dermatology-specific proxy health-related quality of life (HRQoL) instrument for children from birth to 4 years. The aim of the present study was to confirm the responsiveness and establish minimal clinically important difference (MCID) for the InToDermQoL. Methods Parents of children with skin diseases were asked to fill in the InToDermQoL at the initial visit (T1) and subsequent consultation (T2). We hypothesized that correlations between change scores of the InToDermQoL and change scores of global assessment of clinical severity by dermatologists and by patients’ parents should be above 0.3. The receiver operating characteristic (ROC) curves method was also used for confirmation of responsiveness and determination of MCIDs of the InToDermQoL. The area under the ROC curve (AUC) was used as an indicator of responsiveness. Results Results of 442 patients were included. Correlations between change scores of age-specific versions of the InToDermQoL and change scores of global assessment of clinical severity by dermatologists and by patients’ parents were above 0.3 (0.46-0.74). AUCs for age-specific versions of the InToDermQoL were acceptable (above 0.7) or excellent (above 0.8). Estimated MCIDs for the InToDermQoL were as follows: 3 points of total score change for 0–11 months, 5 for 1–2 years and 3 or 4 for 3–4 years version. Estimated MCIDs for the InToDermQoL version for 1–2-year-old children was higher than MCIDs for the 3–4-year-old version despite the higher number of items in the latter. Therefore a MCID of 5 was recommended for both these versions. Conclusions Responsiveness for all age-specific versions of the InToDermQoL questionnaire was confirmed. MCIDs for the InToDermQoL are proposed as follows: 3-point change of the total score for age version 0–11 months and 5-point for the age versions 1–2 years and 3–4 years.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2193-8210 2190-9172
DOI:	10.1007/s13555-023-01022-x